Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins

Mori, Saho; Arakawa, Yuya; Hasegawa, Mika; Kato, Shiho; Hashimoto, Hinako; Yoshioka, Saki; Ueda, Hiromichi; Research Group, Osaka Twin; Watanabe, Mikio

doi:https://doi.org/10.1016/j.gene.2024.149093

Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins

Mori, Saho; Arakawa, Yuya; Hasegawa, Mika et al.

Gene, 2025, 936, 149093

アクセス数:22件（2025-04-03 19:03 集計）

固定URL: https://hdl.handle.net/11094/100203

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タイトル	Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins
著者	著者名 Mori, Saho
	NRID 1000030733175 1000030733175 researchmap permalink ara-y ara-y 著者名 Arakawa, Yuya
	著者名 Hasegawa, Mika
	著者名 Kato, Shiho
	著者名 Hashimoto, Hinako
	著者名 Yoshioka, Saki
	NRID 1000030865746 1000030865746 researchmap permalink hiromichiueda hiromichiueda 著者名 Ueda, Hiromichi
	著者名 Research Group, Osaka Twin
	NRID 1000050294088 1000050294088 ORCID 0000-0001-5971-9296 0000-0001-5971-9296 researchmap permalink watanabemikio watanabemikio Scopus Author ID 55793188612 55793188612 著者名 Watanabe, Mikio
キーワード等	Carotid ultrasonography
	DNA methylation
	Intima-media thickness
	RNA sequencing
	Single nucleotide polymorphisms
	Subclinical atherosclerosis
	Twin study
内容	Mori S., Arakawa Y., Hasegawa M., et al. Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins. Gene 936, 149093 (2025); https://doi.org/10.1016/j.gene.2024.149093.
抄録	Background and aims: The intima-media thickness (IMT) of the carotid artery, an indicator of subclinical atherosclerosis, varies in close association with various factors such as diabetes and immune response. The extent of changes in IMT varies among individuals owing to both genetic and epigenetic factors. In this study, we aimed to identify single nucleotide polymorphisms (SNPs) and DNA methylation patterns that affect carotid IMT in monozygotic (MZ) twins. Methods: We measured the maximum IMT (IMT-Cmax) and the mean IMT in the common carotid artery wall using ultrasonography in 107 pairs of MZ twins recruited from the Osaka University Twin Registry. The genotyping of SNPs and the measurement of methylation levels were performed using a beads array, and the expression of each gene was determined by RNA sequencing. Linear regression analysis was performed on each of the two groups: one group consisted of twins randomly selected from each pair, and the other group consisted of co-twins. Results: We identified a CpG site (cg02432467) on HS3ST6 as a significant epigenetic factor in both IMT-Cmax and mean IMT analyses. The methylation level at another site (cg07927379) was negatively correlated with LINC01006 expression and IMT-Cmax. Furthermore, there were significant differences in AP2A2 expression and mean IMT among individuals with each genotype of the rs10902263 polymorphism. Conclusions: We identified genetic and epigenetic factors associated with carotid IMT that may be useful for individualized assessments.
出版者	Elsevier B.V.
収録物名	Gene
巻(号)	936
ページ	149093
刊行年月	2025-02-05
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100203
PISSN	03781119
eISSN	18790038
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.gene.2024.149093
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Gene. 2025, 936, p. 149093
DC.title	Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins
DC.creator	Mori, Saho
	Arakawa, Yuya
	Hasegawa, Mika
	Kato, Shiho
	Hashimoto, Hinako
	Yoshioka, Saki
	Ueda, Hiromichi
	Research Group, Osaka Twin
	Watanabe, Mikio
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-05
DC.identifier	https://doi.org/10.1016/j.gene.2024.149093
DC.subject	Carotid ultrasonography
	DNA methylation
	Intima-media thickness
	RNA sequencing
	Single nucleotide polymorphisms
	Subclinical atherosclerosis
	Twin study
DC.description	Mori S., Arakawa Y., Hasegawa M., et al. Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins. Gene 936, 149093 (2025); https://doi.org/10.1016/j.gene.2024.149093.
DCTERMS.abstract	Background and aims: The intima-media thickness (IMT) of the carotid artery, an indicator of subclinical atherosclerosis, varies in close association with various factors such as diabetes and immune response. The extent of changes in IMT varies among individuals owing to both genetic and epigenetic factors. In this study, we aimed to identify single nucleotide polymorphisms (SNPs) and DNA methylation patterns that affect carotid IMT in monozygotic (MZ) twins. Methods: We measured the maximum IMT (IMT-Cmax) and the mean IMT in the common carotid artery wall using ultrasonography in 107 pairs of MZ twins recruited from the Osaka University Twin Registry. The genotyping of SNPs and the measurement of methylation levels were performed using a beads array, and the expression of each gene was determined by RNA sequencing. Linear regression analysis was performed on each of the two groups: one group consisted of twins randomly selected from each pair, and the other group consisted of co-twins. Results: We identified a CpG site (cg02432467) on HS3ST6 as a significant epigenetic factor in both IMT-Cmax and mean IMT analyses. The methylation level at another site (cg07927379) was negatively correlated with LINC01006 expression and IMT-Cmax. Furthermore, there were significant differences in AP2A2 expression and mean IMT among individuals with each genotype of the rs10902263 polymorphism. Conclusions: We identified genetic and epigenetic factors associated with carotid IMT that may be useful for individualized assessments.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100203
citation_title	Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins
citation_author	Mori, Saho
	Arakawa, Yuya
	Hasegawa, Mika
	Kato, Shiho
	Hashimoto, Hinako
	Yoshioka, Saki
	Ueda, Hiromichi
	Research Group, Osaka Twin
	Watanabe, Mikio
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2025-02-05
citation_journal_title	Gene
citation_volume	936
citation_firstpage	149093
citation_doi	https://doi.org/10.1016/j.gene.2024.149093
citation_public_url	https://hdl.handle.net/11094/100203

Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins

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