Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation

Kakuta, Yoichi; Miyagawa, Shuji; Matsumura, Soichi; Higa-Maegawa, Yoko; Fukae, Shota; Tanaka, Ryo; Nakazawa, Shigeaki; Yamanaka, Kazuaki; Kawamura, Takuji; Saito, Shunsuke; Miyagawa, Shigeru; Nonomura, Norio

doi:https://doi.org/10.1016/j.trre.2024.100885

Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation

Kakuta, Yoichi; Miyagawa, Shuji; Matsumura, Soichi et al.

Transplantation Reviews, 2025, 39(1), 100885

アクセス数:1,453件（2025-07-22 20:50 集計）

固定URL: https://hdl.handle.net/11094/100204

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タイトル	Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation
著者	NRID 1000040710116 1000040710116 researchmap permalink 987654321 987654321 ORCID 0000-0001-5339-4312 0000-0001-5339-4312 著者名 Kakuta, Yoichi
	NRID 1000090273648 1000090273648 researchmap permalink read0185079 read0185079 著者名 Miyagawa, Shuji
	NRID 1000090981986 1000090981986 著者名 Matsumura, Soichi
	著者名 Higa-Maegawa, Yoko
	NRID 1000000964397 1000000964397 著者名 Fukae, Shota
	著者名 Tanaka, Ryo
	NRID 1000080759530 1000080759530 ORCID 0000-0001-5857-3483 0000-0001-5857-3483 researchmap permalink snakazawa snakazawa Scopus Author ID 36350232600 36350232600 著者名 Nakazawa, Shigeaki
	NRID 1000010648017 1000010648017 researchmap permalink yamanaka.kazuaki yamanaka.kazuaki Scopus Author ID 16318062300 16318062300 著者名 Yamanaka, Kazuaki
	NRID 1000060839398 1000060839398 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 著者名 Kawamura, Takuji
	NRID 1000030600126 1000030600126 ORCID 0000-0002-0829-2891 0000-0002-0829-2891 researchmap permalink shunsaito shunsaito Scopus Author ID 57205524320 57205524320 著者名 Saito, Shunsuke
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 著者名 Miyagawa, Shigeru
	NRID 1000030263263 1000030263263 researchmap permalink read0185096 read0185096 Scopus Author ID 7005880662 7005880662 著者名 Nonomura, Norio
キーワード等	Antibody-mediated rejection
	Complement regulatory proteins
	Complement system
	Kidney transplantation
	Xenotransplantation
内容	Kakuta Y., Miyagawa S., Matsumura S., et al. Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation. Transplantation Reviews 39, 100885 (2025); https://doi.org/10.1016/j.trre.2024.100885.
抄録	Kidney transplantation is the most optimal treatment for patients with end-stage renal disease, offering significant improvements in patient outcomes over dialysis. However, the potential for immune rejection, where the recipient's immune system attacks the transplanted kidney, can compromise transplant success. The complement system, a key component of the immune response, plays a crucial role in both acute and chronic rejection, including T-cell- and antibody-mediated rejection. Understanding and controlling the complement system is essential for managing rejection and enhancing graft survival and overall success of kidney transplantation. In allogeneic transplantation, complement activation through various pathways contributes to graft damage and failure. Recent advancements in genetic engineering enable the development of transgenic pigs expressing human complement regulatory proteins, which display potential for reducing rejection in xenotransplantation. Despite these advances, the complex mechanisms of complement activation and regulation are not fully understood, necessitating further research. This review examines the role of the complement system in kidney transplantation, explores the latest developments in complement regulatory strategies, and discusses potential therapeutic approaches to improve transplant outcomes.
出版者	Elsevier Inc.
収録物名	Transplantation Reviews
巻(号)	39(1)
ページ	100885
刊行年月	2025-01-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100204
PISSN	0955470X
eISSN	15579816
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.trre.2024.100885
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Transplantation Reviews. 2025, 39(1), p. 100885
DC.title	Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation
DC.creator	Kakuta, Yoichi
	Miyagawa, Shuji
	Matsumura, Soichi
	Higa-Maegawa, Yoko
	Fukae, Shota
	Tanaka, Ryo
	Nakazawa, Shigeaki
	Yamanaka, Kazuaki
	Kawamura, Takuji
	Saito, Shunsuke
	Miyagawa, Shigeru
	Nonomura, Norio
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-01-01
DC.identifier	https://doi.org/10.1016/j.trre.2024.100885
DC.subject	Antibody-mediated rejection
	Complement regulatory proteins
	Complement system
	Kidney transplantation
	Xenotransplantation
DC.description	Kakuta Y., Miyagawa S., Matsumura S., et al. Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation. Transplantation Reviews 39, 100885 (2025); https://doi.org/10.1016/j.trre.2024.100885.
DCTERMS.abstract	Kidney transplantation is the most optimal treatment for patients with end-stage renal disease, offering significant improvements in patient outcomes over dialysis. However, the potential for immune rejection, where the recipient's immune system attacks the transplanted kidney, can compromise transplant success. The complement system, a key component of the immune response, plays a crucial role in both acute and chronic rejection, including T-cell- and antibody-mediated rejection. Understanding and controlling the complement system is essential for managing rejection and enhancing graft survival and overall success of kidney transplantation. In allogeneic transplantation, complement activation through various pathways contributes to graft damage and failure. Recent advancements in genetic engineering enable the development of transgenic pigs expressing human complement regulatory proteins, which display potential for reducing rejection in xenotransplantation. Despite these advances, the complex mechanisms of complement activation and regulation are not fully understood, necessitating further research. This review examines the role of the complement system in kidney transplantation, explores the latest developments in complement regulatory strategies, and discusses potential therapeutic approaches to improve transplant outcomes.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100204
citation_title	Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation
citation_author	Kakuta, Yoichi
	Miyagawa, Shuji
	Matsumura, Soichi
	Higa-Maegawa, Yoko
	Fukae, Shota
	Tanaka, Ryo
	Nakazawa, Shigeaki
	Yamanaka, Kazuaki
	Kawamura, Takuji
	Saito, Shunsuke
	Miyagawa, Shigeru
	Nonomura, Norio
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2025-01-01
citation_journal_title	Transplantation Reviews
citation_volume	39
citation_issue	1
citation_firstpage	100885
citation_doi	https://doi.org/10.1016/j.trre.2024.100885
citation_public_url	https://hdl.handle.net/11094/100204

Complement and complement regulatory protein in allogeneic and xenogeneic kidney transplantation

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