Predictive value of enhanced corneal biomechanical parameters for ectasia progression

Koh, Shizuka; Ambrósio, Renato; Inoue, Ryota; Belin, W. Michael; Maeda, Naoyuki; Nishida, Kohji

doi:https://doi.org/10.1007/s10384-024-01149-0

Predictive value of enhanced corneal biomechanical parameters for ectasia progression

Koh, Shizuka; Ambrósio, Renato; Inoue, Ryota et al.

Japanese Journal of Ophthalmology, 2025

アクセス数:473件（2025-08-18 20:55 集計）

固定URL: https://hdl.handle.net/11094/100321

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タイトル	Predictive value of enhanced corneal biomechanical parameters for ectasia progression
著者	NRID 1000000570590 1000000570590 ORCID 0000-0002-5402-3051 0000-0002-5402-3051 researchmap permalink skoh skoh Scopus Author ID 7202061578 7202061578 著者名 Koh, Shizuka
	著者名 Ambrósio, Renato
	著者名 Inoue, Ryota
	著者名 Belin, W. Michael
	NRID 1000000273623 1000000273623 researchmap permalink read0185086 read0185086 著者名 Maeda, Naoyuki
	NRID 1000040244610 1000040244610 ORCID 0000-0001-9069-3610 0000-0001-9069-3610 researchmap permalink read0131487 read0131487 Scopus Author ID 57211973404 57211973404 著者名 Nishida, Kohji
内容	The version of record of this article, first published in Japanese Journal of Ophthalmology, is available online at Publisher’s website: https://doi.org/s10384-024-01149-0.
抄録	Purpose: To determine whether corneal biomechanical parameters can predict ectasia progression. Study design: Retrospective observational study. Methods:The baseline corneal biomechanical parameters of 64 eyes of 41 young patients (age, < 25 years at the first visit) who were diagnosed with keratoconus (KC) or suspected KC at Osaka University Hospital and followed up for more than two years were reviewed. Suspected KC was defined as borderline cases with no definitive clinical or topographical abnormalities in both eyes. The eyes were divided into progressed (P) and non-progressed (NP) groups using the ABCD grading system of Scheimpflug-based tomography. The Scheimpflug-based corneal biomechanical parameters evaluated included deformation amplitude ratio within 2 mm, integrated radius, Ambrósio relational thickness to the horizontal profile, stiffness parameter at the first applanation, stress–strain index, E-staging, and Corvis Biomechanical Index. The optimized tomographic/biomechanical index (TBIv2), Belin/Ambrósio Enhanced Ectasia Deviation (BAD-D), and inferior-superior axial steepening values from Scheimpflug-based tomography were also evaluated.Results: Twenty-three and 41 eyes were categorized into the P and NP groups, respectively. Logistic regression analysis showed that age, BAD-D, and TBIv2 could predict ectasia progression. The specificity, sensitivity, and area under the receiver operating characteristic curve (AUROC) values for BAD-D combined with age were 0.82, 0.60, and 0.83, respectively, whereas those for TBIv2 combined with age were 0.65, 0.82, and 0.82, respectively.Conclusions: Baseline TBIv2 is a potentially useful predictive marker for ectasia progression in young patients, whereas baseline BAD-D could be used for establishing a definitive diagnosis.
出版者	Springer Science and Business Media LLC
収録物名	Japanese Journal of Ophthalmology
刊行年月	2025-01-20
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100321
PISSN	00215155
eISSN	16132246
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10384-024-01149-0
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Japanese Journal of Ophthalmology. 2025
DC.title	Predictive value of enhanced corneal biomechanical parameters for ectasia progression
DC.creator	Koh, Shizuka
	Ambrósio, Renato
	Inoue, Ryota
	Belin, W. Michael
	Maeda, Naoyuki
	Nishida, Kohji
DC.publisher	Springer Science and Business Media LLC
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-01-20
DC.identifier	https://doi.org/10.1007/s10384-024-01149-0
DC.description	The version of record of this article, first published in Japanese Journal of Ophthalmology, is available online at Publisher’s website: https://doi.org/s10384-024-01149-0.
DCTERMS.abstract	Purpose: To determine whether corneal biomechanical parameters can predict ectasia progression. Study design: Retrospective observational study. Methods:The baseline corneal biomechanical parameters of 64 eyes of 41 young patients (age, < 25 years at the first visit) who were diagnosed with keratoconus (KC) or suspected KC at Osaka University Hospital and followed up for more than two years were reviewed. Suspected KC was defined as borderline cases with no definitive clinical or topographical abnormalities in both eyes. The eyes were divided into progressed (P) and non-progressed (NP) groups using the ABCD grading system of Scheimpflug-based tomography. The Scheimpflug-based corneal biomechanical parameters evaluated included deformation amplitude ratio within 2 mm, integrated radius, Ambrósio relational thickness to the horizontal profile, stiffness parameter at the first applanation, stress–strain index, E-staging, and Corvis Biomechanical Index. The optimized tomographic/biomechanical index (TBIv2), Belin/Ambrósio Enhanced Ectasia Deviation (BAD-D), and inferior-superior axial steepening values from Scheimpflug-based tomography were also evaluated.Results: Twenty-three and 41 eyes were categorized into the P and NP groups, respectively. Logistic regression analysis showed that age, BAD-D, and TBIv2 could predict ectasia progression. The specificity, sensitivity, and area under the receiver operating characteristic curve (AUROC) values for BAD-D combined with age were 0.82, 0.60, and 0.83, respectively, whereas those for TBIv2 combined with age were 0.65, 0.82, and 0.82, respectively.Conclusions: Baseline TBIv2 is a potentially useful predictive marker for ectasia progression in young patients, whereas baseline BAD-D could be used for establishing a definitive diagnosis.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100321
citation_title	Predictive value of enhanced corneal biomechanical parameters for ectasia progression
citation_author	Koh, Shizuka
	Ambrósio, Renato
	Inoue, Ryota
	Belin, W. Michael
	Maeda, Naoyuki
	Nishida, Kohji
citation_publisher	Springer Science and Business Media LLC
citation_language	英語
citation_date	2025-01-20
citation_journal_title	Japanese Journal of Ophthalmology
citation_doi	https://doi.org/10.1007/s10384-024-01149-0
citation_public_url	https://hdl.handle.net/11094/100321

Predictive value of enhanced corneal biomechanical parameters for ectasia progression

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