Postoperative outcomes of biopsy versus debulking surgery for immunoglobulin G4-related ophthalmic disease: a retrospective comparative study

Iwasaki, Rikako; Kitaguchi, Yoshiyuki; Morimoto, Takeshi et al.

Japanese Journal of Ophthalmology, 2025

アクセス数:523件（2025-08-18 23:08 集計）

固定URL: https://hdl.handle.net/11094/100325

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タイトル
Postoperative outcomes of biopsy versus debulking surgery for immunoglobulin G4-related ophthalmic disease: a retrospective comparative study
著者
著者名
Iwasaki, Rikako
NRID
1000030772842 1000030772842
researchmap permalink
ykitaguchi ykitaguchi
Scopus Author ID
57191363520 57191363520
著者名
Kitaguchi, Yoshiyuki
NRID
1000000530198 1000000530198
ORCID
0000-0002-9653-1556 0000-0002-9653-1556
researchmap permalink
tmorimoto-eye tmorimoto-eye
Scopus Author ID
24503733900 24503733900
著者名
Morimoto, Takeshi
NRID
1000040244610 1000040244610
ORCID
0000-0001-9069-3610 0000-0001-9069-3610
researchmap permalink
read0131487 read0131487
Scopus Author ID
57211973404 57211973404
著者名
Nishida, Kohji
キーワード等
Biopsy
Debulking
IgG4-related ophthalmic disease
Treatment
内容
The version of record of this article, first published in Japanese Journal of Ophthalmology, is available online at Publisher’s website: https://doi.org/10.1007/s10384-024-01157-0.
抄録
Purpose: To compare the postoperative outcomes of corticosteroid therapy following biopsy with those following debulking surgery in patients with immunoglobulin G4 (IgG4)-related ophthalmic disease (IgG4-ROD). Study Design: Retrospective comparative study. Methods: Fifteen patients diagnosed with IgG4-ROD (5 unilateral, 10 bilateral) were retrospectively analyzed. IgG4-ROD was diagnosed based on imaging, histopathology, and blood test results. The biopsy group included patients who underwent resection of minimal tissue for diagnosis, whereas the debulking group included patients who underwent resection of a substantial portion of the mass to decrease the tumor size. Postoperative outcomes after steroid administration, recurrence rates, and changes in lacrimal gland function were compared between the groups.Results: The biopsy and debulking groups included seven and eight patients, respectively. All patients in the biopsy group and 25% of patients in the debulking group required steroid treatment postoperatively (p = 0.0070). Relapse occurred in 71.4% and 12.5% (p = 0.041) and maintenance therapy was required in 57.1% and 12.5% (p = 0.12) patients in the biopsy and debulking groups, respectively. Twelve patients had extraorbital lesions, with one patient receiving corticosteroid treatment for sphenoid bone lesion. Schirmer I test values did not differ preoperatively and postoperatively in either group (biopsy: p = 0.47; debulking: p = 0.72). One patient from the biopsy group developed severe dry eyes, necessitating lacrimal canalicular excision. Conclusions: Debulking surgery effectively reduced the requirement for postoperative steroid administration for recurrent lacrimal gland lesion in patients with IgG4-ROD, indicating its potential as an effective alternative to current standard treatment.
出版者
Springer Science and Business Media LLC
収録物名
Japanese Journal of Ophthalmology
刊行年月
2025-01-20
言語
英語
ハンドルURL
https://hdl.handle.net/11094/100325
PISSN
00215155
eISSN
16132246
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1007/s10384-024-01157-0
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article