Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

Hashida, Nao; Suzuki, Motoyuki; Hosokawa, Kiyohito; Takenaka, Yukinori; Fukusumi, Takahito; Takemoto, Norihiko; Tanaka, Hidenori; Kitamura, Koji; Eguchi, Hirotaka; Umatani, Masanori; Kitayama, Itsuki; Nozawa, Masayuki; Kato, Chieri; Okajima, Eri; Inohara, Hidenori

doi:https://doi.org/10.1007/s00520-024-09134-6

Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

Hashida, Nao; Suzuki, Motoyuki; Hosokawa, Kiyohito et al.

Supportive care in cancer, 2025, 33, 97

アクセス数:2,055件（2025-08-24 04:06 集計）

固定URL: https://hdl.handle.net/11094/100328

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タイトル	Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer
著者	著者名 Hashida, Nao
	NRID 1000050632329 1000050632329 researchmap permalink motoyukisuzuki motoyukisuzuki Scopus Author ID 55505806400 55505806400 著者名 Suzuki, Motoyuki
	NRID 1000060625896 1000060625896 ORCID 0000-0002-5169-1038 0000-0002-5169-1038 researchmap permalink drink drink Scopus Author ID 55914870000 55914870000 著者名 Hosokawa, Kiyohito
	NRID 1000040598398 1000040598398 ORCID 0000-0002-3135-5635 0000-0002-3135-5635 researchmap permalink yukinoritakenaka yukinoritakenaka Scopus Author ID 7102054128 7102054128 著者名 Takenaka, Yukinori
	NRID 1000070623734 1000070623734 ORCID 0009-0002-1857-7548 0009-0002-1857-7548 researchmap permalink 2933 2933 Scopus Author ID 54893429600 54893429600 著者名 Fukusumi, Takahito
	NRID 1000020636485 1000020636485 著者名 Takemoto, Norihiko
	NRID 1000000804379 1000000804379 ORCID 0000-0002-7516-9180 0000-0002-7516-9180 researchmap permalink hidenoritanaka hidenoritanaka 著者名 Tanaka, Hidenori
	NRID 1000040804365 1000040804365 researchmap permalink kitamura1009 kitamura1009 著者名 Kitamura, Koji
	researchmap permalink eguchi-hirotaka eguchi-hirotaka Scopus Author ID 57203344374 57203344374 著者名 Eguchi, Hirotaka
	NRID 1000000804353 1000000804353 researchmap permalink muma_osaka muma_osaka 著者名 Umatani, Masanori
	ORCID 0009-0006-6551-2818 0009-0006-6551-2818 researchmap permalink itkktym itkktym 著者名 Kitayama, Itsuki
	著者名 Nozawa, Masayuki
	著者名 Kato, Chieri
	著者名 Okajima, Eri
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 著者名 Inohara, Hidenori
キーワード等	Acute side effect
	Delayed swallowing initiation
	Swallowing response
内容	The version of record of this article, first published in Supportive care in cancer, is available online at Publisher’s website: https://doi.org/10.1007/s00520-024-09134-6.
抄録	PURPOSE: Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, and persists for a few weeks thereafter. Thus, understanding the changes in swallowing physiology during and immediately after CRT is essential. This study aimed to clarify the changes in the swallowing response during and early after CRT and identify associated factors. METHODS: This retrospective study enrolled 107 patients with HNC who underwent CRT. We measured pharyngeal delay time (PDT) and laryngeal elevation delay time (LEDT) as indicators of the timing of the swallowing response at three time points: at CRT initiation (baseline), at 40-Gy irradiation during CRT (mid-CRT) and within 2 weeks following the completion of CRT (early post-CRT) as primary outcomes; and subgroup analyses based on clinical parameters, such as tumor sites, T stage, N stage, and opioid use at 40-Gy irradiation as secondary outcomes. RESULTS: Both PDT and LEDT were significantly prolonged between baseline and mid-CRT (PDT: p = 0.003, LEDT: p = 0.002) and between baseline and early post-CRT (PDT, p = 0.001; LEDT, p < 0.001). N2c/N3 and opioid use at 40-Gy irradiation showed prolonged PDT and LEDT at mid-CRT and early post-CRT. CONCLUSION: PDT and LEDT were prolonged at mid-CRT irradiation and further extended at early post-CRT. Additionally, N2c/N3 involvement, which typically necessitates bilateral neck irradiation fields and opioid use at mid-CRT, may constitute as risk factors for a delayed swallowing response.
出版者	Springer Nature
収録物名	Supportive care in cancer
巻(号)	33
ページ	97
刊行年月	2025-02-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100328
eISSN	14337339
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s00520-024-09134-6
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Supportive care in cancer. 2025, 33, p. 97
DC.title	Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer
DC.creator	Hashida, Nao
	Suzuki, Motoyuki
	Hosokawa, Kiyohito
	Takenaka, Yukinori
	Fukusumi, Takahito
	Takemoto, Norihiko
	Tanaka, Hidenori
	Kitamura, Koji
	Eguchi, Hirotaka
	Umatani, Masanori
	Kitayama, Itsuki
	Nozawa, Masayuki
	Kato, Chieri
	Okajima, Eri
	Inohara, Hidenori
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-01
DC.identifier	https://doi.org/10.1007/s00520-024-09134-6
DC.subject	Acute side effect
	Delayed swallowing initiation
	Swallowing response
DC.description	The version of record of this article, first published in Supportive care in cancer, is available online at Publisher’s website: https://doi.org/10.1007/s00520-024-09134-6.
DCTERMS.abstract	PURPOSE: Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, and persists for a few weeks thereafter. Thus, understanding the changes in swallowing physiology during and immediately after CRT is essential. This study aimed to clarify the changes in the swallowing response during and early after CRT and identify associated factors. METHODS: This retrospective study enrolled 107 patients with HNC who underwent CRT. We measured pharyngeal delay time (PDT) and laryngeal elevation delay time (LEDT) as indicators of the timing of the swallowing response at three time points: at CRT initiation (baseline), at 40-Gy irradiation during CRT (mid-CRT) and within 2 weeks following the completion of CRT (early post-CRT) as primary outcomes; and subgroup analyses based on clinical parameters, such as tumor sites, T stage, N stage, and opioid use at 40-Gy irradiation as secondary outcomes. RESULTS: Both PDT and LEDT were significantly prolonged between baseline and mid-CRT (PDT: p = 0.003, LEDT: p = 0.002) and between baseline and early post-CRT (PDT, p = 0.001; LEDT, p < 0.001). N2c/N3 and opioid use at 40-Gy irradiation showed prolonged PDT and LEDT at mid-CRT and early post-CRT. CONCLUSION: PDT and LEDT were prolonged at mid-CRT irradiation and further extended at early post-CRT. Additionally, N2c/N3 involvement, which typically necessitates bilateral neck irradiation fields and opioid use at mid-CRT, may constitute as risk factors for a delayed swallowing response.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100328
citation_title	Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer
citation_author	Hashida, Nao
	Suzuki, Motoyuki
	Hosokawa, Kiyohito
	Takenaka, Yukinori
	Fukusumi, Takahito
	Takemoto, Norihiko
	Tanaka, Hidenori
	Kitamura, Koji
	Eguchi, Hirotaka
	Umatani, Masanori
	Kitayama, Itsuki
	Nozawa, Masayuki
	Kato, Chieri
	Okajima, Eri
	Inohara, Hidenori
citation_publisher	Springer Nature
citation_language	英語
citation_date	2025-02-01
citation_journal_title	Supportive care in cancer
citation_volume	33
citation_firstpage	97
citation_doi	https://doi.org/10.1007/s00520-024-09134-6
citation_public_url	https://hdl.handle.net/11094/100328

Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

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