Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats

Yang, Shengsen; Usami, Nayuka; Lu, Shiou-Ling et al.

Biochemical and Biophysical Research Communications, 2025, 744, 151178

アクセス数:712件（2025-08-15 05:10 集計）

固定URL: https://hdl.handle.net/11094/100384

閲覧可能ファイル 

ファイル フォーマット 利用条件 サイズ 閲覧回数 利用開始日 説明 information
BiochemBiophysResCommun_744_151178 pdf なし 5.33 MB 26 2025.02.20  
Creative Commons : 表示

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル
Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats
著者
著者名
Yang, Shengsen
著者名
Usami, Nayuka
NRID
1000080830083 1000080830083
researchmap permalink
sally711017 sally711017
Scopus Author ID
39863311300 39863311300
著者名
Lu, Shiou-Ling
NRID
1000010964869 1000010964869
著者名
Oda, Wakana
NRID
1000010711012 1000010711012
researchmap permalink
maega maega
Scopus Author ID
36604752300 36604752300
著者名
Maegawa, Hiroharu
NRID
1000030218250 1000030218250
researchmap permalink
19580710 19580710
Scopus Author ID
24351577000 24351577000
著者名
Niwa, Hitoshi
NRID
1000020533110 1000020533110
researchmap permalink
chihokudo chihokudo
Scopus Author ID
6701693347 6701693347
著者名
Kudo, Chiho
内容
Yang S., Usami N., Lu S.L., et al. Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats. Biochemical and Biophysical Research Communications 744, 151178 (2025); https://doi.org/10.1016/j.bbrc.2024.151178.
抄録
Pain is a major non-motor symptom of Parkinson's disease (PD). The relationship between hyperalgesia and neuropeptides originating from paraventricular nucleus (PVN) in 6-hydroxydopamine (6-OHDA) rats has already been investigated for oxytocin (OXT), but not yet for arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH). The present study aimed to investigate the alterations in these neuropeptides following nociceptive stimulation in PD model rats and to examine the mechanisms of hyperalgesia. Dopaminergic nigrostriatal lesions were induced by injecting 6-OHDA into the medial forebrain bundle. Subcutaneous formalin injection into the vibrissa pad was performed in rats as a nociceptive stimulus in the orofacial region. Dopamine depletion's effect on nociception was assessed by counting the p-ERK-immunoreactive (-IR) cells in the trigeminal spinal subnucleus caudalis (Vc). The PD model rats induced by 6-OHDA injection (6-OHDA rats) showed a significantly higher number of p-ERK-IR cells in the Vc than the sham rats, confirming hyperalgesia in 6-OHDA rats. Then, we investigated the immunohistochemical responses to OXT, AVP, and CRH cells in the PVN and examined the changes in blood levels of these neuropeptides. As a result, formalin injection increased neuronal activity and blood levels of OXT and CRH in sham rats, but these were suppressed in the 6-OHDA rats. Contrarily, neuronal activity and blood level of AVP were unaffected by nociceptive stimuli and were significantly lower in 6-OHDA rats than in sham rats. Our findings suggest that OXT and CRH suppression is linked to hyperalgesia in PD, whereas AVP does not directly influence the observed hyperalgesia.
出版者
Elsevier B.V.
収録物名
Biochemical and Biophysical Research Communications
巻(号)
744
ページ
151178
刊行年月
2025-01-01
言語
英語
ハンドルURL
https://hdl.handle.net/11094/100384
PISSN
0006291X
eISSN
10902104
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1016/j.bbrc.2024.151178
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article