Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis

Tahara, Shinichiro; Sato, Kazuaki; Kido, Kansuke et al.

Pathology - Research and Practice, 2025, 266, 155804

アクセス数:14件（2025-03-18 14:18 集計）

固定URL: https://hdl.handle.net/11094/100393

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タイトル
Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis
著者
NRID
1000020792584 1000020792584
ORCID
0000-0001-6134-3275 0000-0001-6134-3275
researchmap permalink
s_tahara s_tahara
Scopus Author ID
57189030096 57189030096
著者名
Tahara, Shinichiro
著者名
Sato, Kazuaki
researchmap permalink
kansukekido kansukekido
著者名
Kido, Kansuke
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
著者名
Morii, Eiichi
内容
Tahara Shinichiro, Sato Kazuaki, Kido Kansuke, et al. Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis. Pathology - Research and Practice 266, 155804 (); https://doi.org/10.1016/j.prp.2024.155804.
抄録
One of the known histological patterns of endometrioid carcinoma (EC) in uterine corpus cancer is MELF (microcystic, elongated, and fragmented). MELF is associated with lymphovascular invasion and lymph node metastasis. Besides MELF, it is also known that squamous differentiation (SD) often occurs in EC. SD is known to be no significant difference in the frequency of lymph node metastasis in EC. However, there have been no previous reports on the association between MELF and SD. In this research, we investigated the presence of SD in MELF using an antibody to CK5. We examined 28 cases of EC with MELF pattern, in which 15 cases showed SD. Moreover, the relation of lymph node metastasis to SD was examined. Lymph node dissection was performed in 27 out of 28 cases. Among them, 12 cases showed lymph node metastasis. The ratio of lymph node metastasis was significantly higher in EC with SD (64.3 %, 9 in 14 cases) than EC without SD (23.1 %, 3 in 13 cases). In this study, we first showed the association between SD and MELF and that MELF with SD is associated with a high ratio of lymph node metastasis. It is clinically relevant to recognize that MELF with SD is aggressive with a high ratio of lymph node metastasis.
出版者
Elsevier BV
収録物名
Pathology - Research and Practice
巻(号)
266
ページ
155804
刊行年月
2025-02-01
言語
英語
ハンドルURL
https://hdl.handle.net/11094/100393
PISSN
03440338
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1016/j.prp.2024.155804
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article