Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

Ukon, Koto; Nojima, Satoshi; Motooka, Daisuke; Takashima, Tsuyoshi; Kohara, Masaharu; Kiyokawa, Hiroki; Kimura, Kenji; Fukui, Eriko; Tahara, Shinichiro; Kido, Kansuke; Matsui, Takahiro; Shintani, Yasushi; Okuzaki, Daisuke; Morii, Eiichi

doi:https://doi.org/10.1016/j.prp.2024.155805

Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

Ukon, Koto; Nojima, Satoshi; Motooka, Daisuke et al.

Pathology - Research and Practice, 2025, 266, 155805

アクセス数:15件（2025-03-18 12:01 集計）

固定URL: https://hdl.handle.net/11094/100394

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タイトル	Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
著者	著者名 Ukon, Koto
	NRID 1000040528791 1000040528791 ORCID 0000-0002-5124-0026 0000-0002-5124-0026 researchmap permalink snojima snojima Scopus Author ID 16224082000 16224082000 著者名 Nojima, Satoshi
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 著者名 Motooka, Daisuke
	著者名 Takashima, Tsuyoshi
	ORCID 0009-0006-7636-5833 0009-0006-7636-5833 著者名 Kohara, Masaharu
	NRID 1000090973785 1000090973785 researchmap permalink hiroki_kiyokawa hiroki_kiyokawa 著者名 Kiyokawa, Hiroki
	NRID 1000050795325 1000050795325 researchmap permalink kenkimurathoracic kenkimurathoracic 著者名 Kimura, Kenji
	NRID 1000090814591 1000090814591 researchmap permalink ef90814591 ef90814591 Scopus Author ID 57205560883 57205560883 著者名 Fukui, Eriko
	NRID 1000020792584 1000020792584 ORCID 0000-0001-6134-3275 0000-0001-6134-3275 researchmap permalink s_tahara s_tahara Scopus Author ID 57189030096 57189030096 著者名 Tahara, Shinichiro
	researchmap permalink kansukekido kansukekido 著者名 Kido, Kansuke
	NRID 1000050747037 1000050747037 ORCID 0000-0002-6753-1688 0000-0002-6753-1688 researchmap permalink takahiromatsui takahiromatsui Scopus Author ID 35176152500 35176152500 著者名 Matsui, Takahiro
	NRID 1000090572983 1000090572983 researchmap permalink shintani6384 shintani6384 Scopus Author ID 7103142734 7103142734 著者名 Shintani, Yasushi
	NRID 1000000346131 1000000346131 ORCID 0000-0002-4552-783X 0000-0002-4552-783X researchmap permalink read0092307 read0092307 Scopus Author ID 6506703054 6506703054 著者名 Okuzaki, Daisuke
	NRID 1000010283772 1000010283772 ORCID 0000-0001-8490-3650 0000-0001-8490-3650 researchmap permalink read0046454 read0046454 Scopus Author ID 7003914326 7003914326 著者名 Morii, Eiichi
内容	Ukon Koto, Nojima Satoshi, Motooka Daisuke, et al. Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity. Pathology - Research and Practice 266, 155805 (); https://doi.org/10.1016/j.prp.2024.155805.
抄録	Interstitial pneumonia (IP) is a refractory disease that causes severe inflammation and fibrosis in the interstitium of the lungs, often resulting in the development of lung cancer (LC) during treatment. Previous studies have demonstrated that the prognosis of LC complicated by IP is inferior to that of LC without IP. It is therefore of the utmost importance to gain a deeper understanding of the heterogeneity of such tumors. In the present study, we conducted spatial transcriptome analysis of squamous cell carcinoma arising from IP. The results suggested involvement of the glucocorticoid receptor pathway in treatment resistance. Immunostaining of squamous cell carcinoma specimens from patients with IP demonstrated that the tumors expressed NR3C1 to varying degrees. Furthermore, higher NR3C1 expression levels were associated with a significantly increased risk of recurrence. Our results point to a novel subtype of lung squamous cell carcinoma. Further analysis of the molecular mechanisms associated with this subtype may facilitate the development of novel diagnostic criteria and therapeutic approaches.
出版者	Elsevier BV
収録物名	Pathology - Research and Practice
巻(号)	266
ページ	155805
刊行年月	2025-02-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100394
PISSN	03440338
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.prp.2024.155805
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Pathology - Research and Practice. 2025, 266, p. 155805
DC.title	Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
DC.creator	Ukon, Koto
	Nojima, Satoshi
	Motooka, Daisuke
	Takashima, Tsuyoshi
	Kohara, Masaharu
	Kiyokawa, Hiroki
	Kimura, Kenji
	Fukui, Eriko
	Tahara, Shinichiro
	Kido, Kansuke
	Matsui, Takahiro
	Shintani, Yasushi
	Okuzaki, Daisuke
	Morii, Eiichi
DC.publisher	Elsevier BV
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-01
DC.identifier	https://doi.org/10.1016/j.prp.2024.155805
DC.description	Ukon Koto, Nojima Satoshi, Motooka Daisuke, et al. Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity. Pathology - Research and Practice 266, 155805 (); https://doi.org/10.1016/j.prp.2024.155805.
DCTERMS.abstract	Interstitial pneumonia (IP) is a refractory disease that causes severe inflammation and fibrosis in the interstitium of the lungs, often resulting in the development of lung cancer (LC) during treatment. Previous studies have demonstrated that the prognosis of LC complicated by IP is inferior to that of LC without IP. It is therefore of the utmost importance to gain a deeper understanding of the heterogeneity of such tumors. In the present study, we conducted spatial transcriptome analysis of squamous cell carcinoma arising from IP. The results suggested involvement of the glucocorticoid receptor pathway in treatment resistance. Immunostaining of squamous cell carcinoma specimens from patients with IP demonstrated that the tumors expressed NR3C1 to varying degrees. Furthermore, higher NR3C1 expression levels were associated with a significantly increased risk of recurrence. Our results point to a novel subtype of lung squamous cell carcinoma. Further analysis of the molecular mechanisms associated with this subtype may facilitate the development of novel diagnostic criteria and therapeutic approaches.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	100394
citation_title	Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
citation_author	Ukon, Koto
	Nojima, Satoshi
	Motooka, Daisuke
	Takashima, Tsuyoshi
	Kohara, Masaharu
	Kiyokawa, Hiroki
	Kimura, Kenji
	Fukui, Eriko
	Tahara, Shinichiro
	Kido, Kansuke
	Matsui, Takahiro
	Shintani, Yasushi
	Okuzaki, Daisuke
	Morii, Eiichi
citation_publisher	Elsevier BV
citation_language	英語
citation_date	2025-02-01
citation_journal_title	Pathology - Research and Practice
citation_volume	266
citation_firstpage	155805
citation_doi	https://doi.org/10.1016/j.prp.2024.155805
citation_public_url	https://hdl.handle.net/11094/100394

Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

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