Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study

Ebina, Kosuke; Kobayakawa, Tomonori; Etani, Yuki; Noguchi, Takaaki; Kashii, Masafumi; Okamura, Gensuke; Nagayama, Yoshio; Tsuboi, Hideki; Miyama, Akira; Hirao, Makoto; Fukuda, Yuji; Kurihara, Takuya; Sugimoto, Atsushi; Nakata, Ken; Okada, Seiji

doi:https://doi.org/10.1016/j.bone.2025.117389

Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study

Ebina, Kosuke; Kobayakawa, Tomonori; Etani, Yuki et al.

Bone, 2025, 193, 117389

アクセス数:1,413件（2025-07-17 14:25 集計）

固定URL: https://hdl.handle.net/11094/100397

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タイトル	Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study
著者	NRID 1000070612076 1000070612076 ORCID 0000-0002-2426-1024 0000-0002-2426-1024 researchmap permalink k-ebina k-ebina Scopus Author ID 8415453300 8415453300 著者名 Ebina, Kosuke
	著者名 Kobayakawa, Tomonori
	NRID 1000060898930 1000060898930 ORCID 0000-0001-5741-5969 0000-0001-5741-5969 researchmap permalink Yetani0302 Yetani0302 著者名 Etani, Yuki
	NRID 1000050812294 1000050812294 researchmap permalink takaakinoguchi takaakinoguchi ORCID 0000-0001-9938-6780 0000-0001-9938-6780 著者名 Noguchi, Takaaki
	NRID 1000000576910 1000000576910 著者名 Kashii, Masafumi
	著者名 Okamura, Gensuke
	著者名 Nagayama, Yoshio
	著者名 Tsuboi, Hideki
	著者名 Miyama, Akira
	NRID 1000010527708 1000010527708 著者名 Hirao, Makoto
	著者名 Fukuda, Yuji
	著者名 Kurihara, Takuya
	著者名 Sugimoto, Atsushi
	NRID 1000000283747 1000000283747 researchmap permalink ken-nakata ken-nakata Scopus Author ID 7402151308 7402151308 著者名 Nakata, Ken
	NRID 1000030448435 1000030448435 ORCID 0000-0002-5107-8209 0000-0002-5107-8209 researchmap permalink okadaseiji okadaseiji Scopus Author ID 35079139100 35079139100 著者名 Okada, Seiji
キーワード等	Bone formation
	Bone mineral density
	Postmenopausal osteoporosis
	Romosozumab
	Teriparatide
内容	Ebina K., Kobayakawa T., Etani Y., et al. Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study. Bone 193, 117389 (2025); https://doi.org/10.1016/j.bone.2025.117389.
抄録	Purpose: To evaluate the impact of prior teriparatide (TPTD) treatment on the effectiveness of romosozumab (ROMO) in postmenopausal osteoporosis. Methods: In this retrospective, case-controlled, multicenter study, 323 postmenopausal patients were initiated ROMO. Of these, 275 were treatment-naïve, and 48 were switched from TPTD, with uninterrupted ROMO treatment for 12 months. Propensity score matching was applied to ensure clinical comparability, yielding 44 patients in each group. Baseline characteristics included a mean age of 78.0 years, lumbar spine (LS) T-score of −3.6, and total hip (TH) T-score of −2.8. Bone mineral density (BMD) and serum bone turnover markers were evaluated over the 12-month period. Results: The increasing rate in the bone formation marker PINP was significantly greater in the treatment-naïve group compared to the TPTD-switched group throughout the 1–12 month period. Conversely, the reduction in the bone resorption marker TRACP-5b was similar between the groups, indicating a diminished anabolic window in the TPTD-switched group. After 12 months, the TPTD-switched group showed lower BMD gains in the LS (10.3 % vs. 17.3 %; P = 0.002) and TH (3.1 % vs. 7.8 %; P = 0.002) compared to the treatment-naïve group. Multiple regression analysis revealed positive associations between the 12-month percentage BMD increases (LS; β = 0.30; 95 % CI = 0.85–11.61; P = 0.024 / TH; β = 0.32; 95 % CI = 0.51–8.56; P = 0.028) and being treatment-naïve compared to prior TPTD treatment. Conclusions: Prior TPTD treatment may attenuate the effectiveness of ROMO, potentially due to diminished bone formation activation.
出版者	Elsevier Inc.
収録物名	Bone
巻(号)	193
ページ	117389
刊行年月	2025-04-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100397
PISSN	87563282
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.bone.2025.117389
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Bone. 2025, 193, p. 117389
DC.title	Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study
DC.creator	Ebina, Kosuke
	Kobayakawa, Tomonori
	Etani, Yuki
	Noguchi, Takaaki
	Kashii, Masafumi
	Okamura, Gensuke
	Nagayama, Yoshio
	Tsuboi, Hideki
	Miyama, Akira
	Hirao, Makoto
	Fukuda, Yuji
	Kurihara, Takuya
	Sugimoto, Atsushi
	Nakata, Ken
	Okada, Seiji
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-04-01
DC.identifier	https://doi.org/10.1016/j.bone.2025.117389
DC.subject	Bone formation
	Bone mineral density
	Postmenopausal osteoporosis
	Romosozumab
	Teriparatide
DC.description	Ebina K., Kobayakawa T., Etani Y., et al. Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study. Bone 193, 117389 (2025); https://doi.org/10.1016/j.bone.2025.117389.
DCTERMS.abstract	Purpose: To evaluate the impact of prior teriparatide (TPTD) treatment on the effectiveness of romosozumab (ROMO) in postmenopausal osteoporosis. Methods: In this retrospective, case-controlled, multicenter study, 323 postmenopausal patients were initiated ROMO. Of these, 275 were treatment-naïve, and 48 were switched from TPTD, with uninterrupted ROMO treatment for 12 months. Propensity score matching was applied to ensure clinical comparability, yielding 44 patients in each group. Baseline characteristics included a mean age of 78.0 years, lumbar spine (LS) T-score of −3.6, and total hip (TH) T-score of −2.8. Bone mineral density (BMD) and serum bone turnover markers were evaluated over the 12-month period. Results: The increasing rate in the bone formation marker PINP was significantly greater in the treatment-naïve group compared to the TPTD-switched group throughout the 1–12 month period. Conversely, the reduction in the bone resorption marker TRACP-5b was similar between the groups, indicating a diminished anabolic window in the TPTD-switched group. After 12 months, the TPTD-switched group showed lower BMD gains in the LS (10.3 % vs. 17.3 %; P = 0.002) and TH (3.1 % vs. 7.8 %; P = 0.002) compared to the treatment-naïve group. Multiple regression analysis revealed positive associations between the 12-month percentage BMD increases (LS; β = 0.30; 95 % CI = 0.85–11.61; P = 0.024 / TH; β = 0.32; 95 % CI = 0.51–8.56; P = 0.028) and being treatment-naïve compared to prior TPTD treatment. Conclusions: Prior TPTD treatment may attenuate the effectiveness of ROMO, potentially due to diminished bone formation activation.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100397
citation_title	Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study
citation_author	Ebina, Kosuke
	Kobayakawa, Tomonori
	Etani, Yuki
	Noguchi, Takaaki
	Kashii, Masafumi
	Okamura, Gensuke
	Nagayama, Yoshio
	Tsuboi, Hideki
	Miyama, Akira
	Hirao, Makoto
	Fukuda, Yuji
	Kurihara, Takuya
	Sugimoto, Atsushi
	Nakata, Ken
	Okada, Seiji
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2025-04-01
citation_journal_title	Bone
citation_volume	193
citation_firstpage	117389
citation_doi	https://doi.org/10.1016/j.bone.2025.117389
citation_public_url	https://hdl.handle.net/11094/100397

Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: A case-control study

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