Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development

Matsumoto, Kanako; Akieda, Yuki; Haraoka, Yukinari; Hirono, Naoki; Sasaki, Hiroshi; Ishitani, Tohru

doi:https://doi.org/10.1038/s41467-024-55108-x

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development

Matsumoto, Kanako; Akieda, Yuki; Haraoka, Yukinari et al.

Nature Communications, 2024, 15, 10662

アクセス数:640件（2025-07-22 20:55 集計）

固定URL: https://hdl.handle.net/11094/100425

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タイトル	Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development
著者	ORCID 0009-0004-3733-7763 0009-0004-3733-7763 著者名 Matsumoto, Kanako
	NRID 1000020770514 1000020770514 researchmap permalink akieda akieda Scopus Author ID 56606072400 56606072400 著者名 Akieda, Yuki
	著者名 Haraoka, Yukinari
	著者名 Hirono, Naoki
	NRID 1000010211939 1000010211939 ORCID 0000-0001-8752-6846 0000-0001-8752-6846 researchmap permalink Hiroshi_Sasaki Hiroshi_Sasaki Scopus Author ID 55248695700 55248695700 著者名 Sasaki, Hiroshi
	NRID 1000040448428 1000040448428 ORCID 0000-0002-6200-7043 0000-0002-6200-7043 researchmap permalink read0148831 read0148831 Scopus Author ID 8079317200 8079317200 著者名 Ishitani, Tohru
内容	Matsumoto K., Akieda Y., Haraoka Y., et al. Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature Communications 15, 10662 (2024); https://doi.org/10.1038/s41467-024-55108-x.
抄録	Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear. In addition, universal mechanisms regulating diverse cell competition are unknown. Using zebrafish imaging, we reveal that cell competition ensures robust patterning of the spinal cord and muscle through elimination of cells with unfit sonic hedgehog activity, driven by cadherin-mediated communication between unfit and neighbouring fit cells and subsequent activation of the Smad-Foxo3-reactive oxygen species axis. We identify Foxo3 as a common marker of loser cells in various types of cell competition in zebrafish and mice. Foxo3-mediated physiological cell competition is required for eliminating various naturally generated unfit cells and for the consequent precise patterning during zebrafish embryogenesis and organogenesis. Given the implication of Foxo3 downregulation in age-related diseases, cell competition may be a defence system to prevent abnormalities throughout development and adult homeostasis.
出版者	Nature Research
収録物名	Nature Communications
巻(号)	15
ページ	10662
刊行年月	2024-12-17
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100425
eISSN	20411723
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41467-024-55108-x
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Nature Communications. 2024, 15, p. 10662
DC.title	Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development
DC.creator	Matsumoto, Kanako
	Akieda, Yuki
	Haraoka, Yukinari
	Hirono, Naoki
	Sasaki, Hiroshi
	Ishitani, Tohru
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-17
DC.identifier	https://doi.org/10.1038/s41467-024-55108-x
DC.description	Matsumoto K., Akieda Y., Haraoka Y., et al. Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature Communications 15, 10662 (2024); https://doi.org/10.1038/s41467-024-55108-x.
DCTERMS.abstract	Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear. In addition, universal mechanisms regulating diverse cell competition are unknown. Using zebrafish imaging, we reveal that cell competition ensures robust patterning of the spinal cord and muscle through elimination of cells with unfit sonic hedgehog activity, driven by cadherin-mediated communication between unfit and neighbouring fit cells and subsequent activation of the Smad-Foxo3-reactive oxygen species axis. We identify Foxo3 as a common marker of loser cells in various types of cell competition in zebrafish and mice. Foxo3-mediated physiological cell competition is required for eliminating various naturally generated unfit cells and for the consequent precise patterning during zebrafish embryogenesis and organogenesis. Given the implication of Foxo3 downregulation in age-related diseases, cell competition may be a defence system to prevent abnormalities throughout development and adult homeostasis.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100425
citation_title	Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development
citation_author	Matsumoto, Kanako
	Akieda, Yuki
	Haraoka, Yukinari
	Hirono, Naoki
	Sasaki, Hiroshi
	Ishitani, Tohru
citation_publisher	Nature Research
citation_language	英語
citation_date	2024-12-17
citation_journal_title	Nature Communications
citation_volume	15
citation_firstpage	10662
citation_doi	https://doi.org/10.1038/s41467-024-55108-x
citation_public_url	https://hdl.handle.net/11094/100425

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development

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