Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome

Okamoto, Naotaka; Mizote, Isamu; Ishihara, Takayuki; Nakamura, Daisuke; Shiraki, Tatsusya; Itaya, Naoki; Tsujimura, Takuya; Takahara, Mitsuyoshi; Hikosou, Shungo; Mano, Toshiaki; Ueno, Takahumi; Nishino, Masami; Nanto, Shinsuke; Sakata, Yasushi

doi:https://doi.org/10.1002/ccd.31430

Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome

Okamoto, Naotaka; Mizote, Isamu; Ishihara, Takayuki et al.

Catheterization and Cardiovascular Interventions, 2025

アクセス数:1,258件（2025-08-16 12:28 集計）

固定URL: https://hdl.handle.net/11094/100545

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タイトル	Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome
著者	著者名 Okamoto, Naotaka
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 著者名 Mizote, Isamu
	著者名 Ishihara, Takayuki
	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 著者名 Nakamura, Daisuke
	NRID 1000060784056 1000060784056 著者名 Shiraki, Tatsusya
	著者名 Itaya, Naoki
	著者名 Tsujimura, Takuya
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 著者名 Takahara, Mitsuyoshi
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv 著者名 Hikosou, Shungo
	著者名 Mano, Toshiaki
	著者名 Ueno, Takahumi
	著者名 Nishino, Masami
	著者名 Nanto, Shinsuke
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 著者名 Sakata, Yasushi
キーワード等	chronic coronary syndrome
	irregular protrusion
	optical coherence tomography
内容	Okamoto N., Mizote I., Ishihara T., et al. Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome. Catheterization and Cardiovascular Interventions, (2025); https://doi.org/10.1002/ccd.31430.
抄録	Background: The changes over time and effects on long-term clinical outcomes beyond 1 year of irregular protrusion (IP) in chronic coronary syndrome (CCS) remains unclear. Aims: This study aimed to assess the time-dependent change and long-term clinical impact of IP in CCS lesions. Methods: This study was a post hoc analysis of COLLABORATION study, which was a multicenter, prospective, observational study conducted from July 2018 to February 2020, assessing 1- and 12-month serial vessel responses after stent implantation using OCT and coronary angioscopy. Time-dependent change in the presence of IP was evaluated using the serial OCT examinations. The cumulative 3-year incidence of TLR was compared between the lesions with and without IP, as well as between those with and without residual IP at 1 month. Results: Among 107 lesions, IP was detected in post-OCT pullbacks in 38 (35.5%) lesions. Out of the 38 lesions, IP remained in 9 (23.7%) lesions at 1 month and existed in 2 (5.3%) lesions at 12 months. The cumulative 3-year incidence of TLR was significantly higher in IP group than in non-IP group (13.6% vs. 3.0%, p = 0.04). Similarly, it was significantly higher in lesions with residual IP at 1 month than those without (33.3% vs. 4.3%, p < 0.01). All residual IP at 1 month were composed of angioscopic yellow plaques and red thrombi. Conclusions: The presence of IP decreased over time, but approximately one-fourth of IP remained at 1 month. IP and residual IP at 1 month were important post-stent OCT findings leading to long-term TLR in patients with CCS.
出版者	John Wiley and Sons Inc
収録物名	Catheterization and Cardiovascular Interventions
刊行年月	2025-02-03
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100545
PISSN	15221946
eISSN	1522726X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1002/ccd.31430
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Catheterization and Cardiovascular Interventions. 2025
DC.title	Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome
DC.creator	Okamoto, Naotaka
	Mizote, Isamu
	Ishihara, Takayuki
	Nakamura, Daisuke
	Shiraki, Tatsusya
	Itaya, Naoki
	Tsujimura, Takuya
	Takahara, Mitsuyoshi
	Hikosou, Shungo
	Mano, Toshiaki
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-03
DC.identifier	https://doi.org/10.1002/ccd.31430
DC.subject	chronic coronary syndrome
	irregular protrusion
	optical coherence tomography
DC.description	Okamoto N., Mizote I., Ishihara T., et al. Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome. Catheterization and Cardiovascular Interventions, (2025); https://doi.org/10.1002/ccd.31430.
DCTERMS.abstract	Background: The changes over time and effects on long-term clinical outcomes beyond 1 year of irregular protrusion (IP) in chronic coronary syndrome (CCS) remains unclear. Aims: This study aimed to assess the time-dependent change and long-term clinical impact of IP in CCS lesions. Methods: This study was a post hoc analysis of COLLABORATION study, which was a multicenter, prospective, observational study conducted from July 2018 to February 2020, assessing 1- and 12-month serial vessel responses after stent implantation using OCT and coronary angioscopy. Time-dependent change in the presence of IP was evaluated using the serial OCT examinations. The cumulative 3-year incidence of TLR was compared between the lesions with and without IP, as well as between those with and without residual IP at 1 month. Results: Among 107 lesions, IP was detected in post-OCT pullbacks in 38 (35.5%) lesions. Out of the 38 lesions, IP remained in 9 (23.7%) lesions at 1 month and existed in 2 (5.3%) lesions at 12 months. The cumulative 3-year incidence of TLR was significantly higher in IP group than in non-IP group (13.6% vs. 3.0%, p = 0.04). Similarly, it was significantly higher in lesions with residual IP at 1 month than those without (33.3% vs. 4.3%, p < 0.01). All residual IP at 1 month were composed of angioscopic yellow plaques and red thrombi. Conclusions: The presence of IP decreased over time, but approximately one-fourth of IP remained at 1 month. IP and residual IP at 1 month were important post-stent OCT findings leading to long-term TLR in patients with CCS.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100545
citation_title	Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome
citation_author	Okamoto, Naotaka
	Mizote, Isamu
	Ishihara, Takayuki
	Nakamura, Daisuke
	Shiraki, Tatsusya
	Itaya, Naoki
	Tsujimura, Takuya
	Takahara, Mitsuyoshi
	Hikosou, Shungo
	Mano, Toshiaki
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2025-02-03
citation_journal_title	Catheterization and Cardiovascular Interventions
citation_doi	https://doi.org/10.1002/ccd.31430
citation_public_url	https://hdl.handle.net/11094/100545

Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome

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