Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

Nakamura, Daisuke; Mizote, Isamu; Ishihara, Takayuki; Matsuhiro, Yutaka; Okuno, Shota; Shiraki, Tatsuya; Tsujimura, Takuya; Okamoto, Naotaka; Itaya, Naoki; Nakayoshi, Takaharu; Kikuchi, Atsushi; Kawai, Tsutomu; Nojima, Yuhei; Takahara, Mitsuyoshi; Morita, Takashi; Hikosou, Shungo; Nakatani, Daisaku; Mano, Toshiaki; Yamada, Takahisa; Ueno, Takahumi; Nishino, Masami; Nanto, Shinsuke; Sakata, Yasushi

doi:https://doi.org/10.1016/j.amjcard.2025.01.009

Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

Nakamura, Daisuke; Mizote, Isamu; Ishihara, Takayuki et al.

American Journal of Cardiology, 2025, 241, 26-36

アクセス数:2,523件（2025-08-15 23:46 集計）

固定URL: https://hdl.handle.net/11094/100575

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タイトル	Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study
著者	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 著者名 Nakamura, Daisuke
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 著者名 Mizote, Isamu
	著者名 Ishihara, Takayuki
	ORCID 0000-0002-5229-6857 0000-0002-5229-6857 著者名 Matsuhiro, Yutaka
	researchmap permalink okunoshota okunoshota 著者名 Okuno, Shota
	NRID 1000060784056 1000060784056 著者名 Shiraki, Tatsuya
	著者名 Tsujimura, Takuya
	著者名 Okamoto, Naotaka
	著者名 Itaya, Naoki
	NRID 1000090511824 1000090511824 著者名 Nakayoshi, Takaharu
	著者名 Kikuchi, Atsushi
	著者名 Kawai, Tsutomu
	著者名 Nojima, Yuhei
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 著者名 Takahara, Mitsuyoshi
	著者名 Morita, Takashi
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv 著者名 Hikosou, Shungo
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 著者名 Nakatani, Daisaku
	NRID 1000090379165 1000090379165 著者名 Mano, Toshiaki
	NRID 1000040649844 1000040649844 著者名 Yamada, Takahisa
	著者名 Ueno, Takahumi
	著者名 Nishino, Masami
	著者名 Nanto, Shinsuke
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 著者名 Sakata, Yasushi
キーワード等	Drug-eluting stent
	Multi vessel disease
	Optical coherence tomography
	Stable angina
内容	Nakamura D., Mizote I., Ishihara T., et al. Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study. American Journal of Cardiology 241, 26 (2025); https://doi.org/10.1016/j.amjcard.2025.01.009.
抄録	A dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo Stent (DTS) has been developed to enhance endothelization and capture endothelial progenitor cells; however, vessel responses following DTS implantation remain unclear. Therefore, we evaluated early- and mid-term intravascular characteristics of DTS using intravascular imaging modalities. This multicenter, prospective, observational study enrolled 88 patients (95 lesions) who underwent DTS (43 patients, 48 lesions) or sirolimus-eluting Orsiro stent (SES, 45 patients, 47 lesions) implantation. Serial optical coherence tomography (OCT) and coronary angioscopy (CAS) findings were compared between the groups at 1 and 12 months.The OCT findings were similar between the DTS and SES groups at 1 month, including the covered strut rate (84.21 ± 9.50% versus 80.56 ± 17.68%, p = 0.27). CAS findings were also comparable despite a more severe yellow coloration observed in the DTS group (p = 0.006). At 12 months, OCT findings revealed that the covered and adequate strut coverage (≥40 μm) rates were significantly higher (99.27 ± 0.95% versus 95.46 ± 5.56%, p <0.001 and 88.90 ± 10.15% versus 72.96 ± 16.48%, p <0.001) and neointimal thickness was significantly thicker (152.16 ± 70.31 versus 84.39 ± 29.80 μm, p <0.001) in DTS than in SES. The malapposed strut rate was significantly higher in SES than in DTS (0.04 ± 0.18% versus 0.82 ± 1.87%, p = 0.018). CAS revealed that the yellow coloration (p = 0.049) and subclinical intrastent thrombus (p = 0.019) were less severe in DTS than in SES at 12 months. In conclusion, DTS provided better advantages regarding strut coverage and plaque stabilization compared to SES. However, given the observational nature of this study, further randomized controlled trials are needed to confirm these findings.
出版者	Elsevier Inc.
収録物名	American Journal of Cardiology
巻(号)	241
ページ	26-36
刊行年月	2025-04-15
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100575
PISSN	00029149
eISSN	18791913
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.amjcard.2025.01.009
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	American Journal of Cardiology. 2025, 241, p. 26-36
DC.title	Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study
DC.creator	Nakamura, Daisuke
	Mizote, Isamu
	Ishihara, Takayuki
	Matsuhiro, Yutaka
	Okuno, Shota
	Shiraki, Tatsuya
	Tsujimura, Takuya
	Okamoto, Naotaka
	Itaya, Naoki
	Nakayoshi, Takaharu
	Kikuchi, Atsushi
	Kawai, Tsutomu
	Nojima, Yuhei
	Takahara, Mitsuyoshi
	Morita, Takashi
	Hikosou, Shungo
	Nakatani, Daisaku
	Mano, Toshiaki
	Yamada, Takahisa
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-04-15
DC.identifier	https://doi.org/10.1016/j.amjcard.2025.01.009
DC.subject	Drug-eluting stent
	Multi vessel disease
	Optical coherence tomography
	Stable angina
DC.description	Nakamura D., Mizote I., Ishihara T., et al. Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study. American Journal of Cardiology 241, 26 (2025); https://doi.org/10.1016/j.amjcard.2025.01.009.
DCTERMS.abstract	A dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo Stent (DTS) has been developed to enhance endothelization and capture endothelial progenitor cells; however, vessel responses following DTS implantation remain unclear. Therefore, we evaluated early- and mid-term intravascular characteristics of DTS using intravascular imaging modalities. This multicenter, prospective, observational study enrolled 88 patients (95 lesions) who underwent DTS (43 patients, 48 lesions) or sirolimus-eluting Orsiro stent (SES, 45 patients, 47 lesions) implantation. Serial optical coherence tomography (OCT) and coronary angioscopy (CAS) findings were compared between the groups at 1 and 12 months.The OCT findings were similar between the DTS and SES groups at 1 month, including the covered strut rate (84.21 ± 9.50% versus 80.56 ± 17.68%, p = 0.27). CAS findings were also comparable despite a more severe yellow coloration observed in the DTS group (p = 0.006). At 12 months, OCT findings revealed that the covered and adequate strut coverage (≥40 μm) rates were significantly higher (99.27 ± 0.95% versus 95.46 ± 5.56%, p <0.001 and 88.90 ± 10.15% versus 72.96 ± 16.48%, p <0.001) and neointimal thickness was significantly thicker (152.16 ± 70.31 versus 84.39 ± 29.80 μm, p <0.001) in DTS than in SES. The malapposed strut rate was significantly higher in SES than in DTS (0.04 ± 0.18% versus 0.82 ± 1.87%, p = 0.018). CAS revealed that the yellow coloration (p = 0.049) and subclinical intrastent thrombus (p = 0.019) were less severe in DTS than in SES at 12 months. In conclusion, DTS provided better advantages regarding strut coverage and plaque stabilization compared to SES. However, given the observational nature of this study, further randomized controlled trials are needed to confirm these findings.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	100575
citation_title	Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study
citation_author	Nakamura, Daisuke
	Mizote, Isamu
	Ishihara, Takayuki
	Matsuhiro, Yutaka
	Okuno, Shota
	Shiraki, Tatsuya
	Tsujimura, Takuya
	Okamoto, Naotaka
	Itaya, Naoki
	Nakayoshi, Takaharu
	Kikuchi, Atsushi
	Kawai, Tsutomu
	Nojima, Yuhei
	Takahara, Mitsuyoshi
	Morita, Takashi
	Hikosou, Shungo
	Nakatani, Daisaku
	Mano, Toshiaki
	Yamada, Takahisa
	Ueno, Takahumi
	Nishino, Masami
	Nanto, Shinsuke
	Sakata, Yasushi
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2025-04-15
citation_journal_title	American Journal of Cardiology
citation_volume	241
citation_firstpage	26
citation_lastpage	36
citation_doi	https://doi.org/10.1016/j.amjcard.2025.01.009
citation_public_url	https://hdl.handle.net/11094/100575

Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

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