Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan

Gon, Yasufumi; Zha, Ling; Morishima, Toshitaka; Kimura, Yasuyoshi; Asai, Kanako; Kudo, Haruka; Sasaki, Tsutomu; Mochizuki, Hideki; Miyashiro, Isao; Sobue, Tomotaka

doi:https://doi.org/10.2188/jea.JE20240230

Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan

Gon, Yasufumi; Zha, Ling; Morishima, Toshitaka et al.

Journal of Epidemiology, 2025, 35(3), 147-153

アクセス数:1,229件（2025-08-15 07:41 集計）

固定URL: https://hdl.handle.net/11094/100601

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
JournalofEpidemiology_35_3_147	pdf	なし	484 KB	29	2025.03.18

Creative Commons : 表示

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan
著者	NRID 1000070751311 1000070751311 researchmap permalink y-gon y-gon Scopus Author ID 56565092900 56565092900 著者名 Gon, Yasufumi
	researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 著者名 Zha, Ling
	NRID 1000010728893 1000010728893 著者名 Morishima, Toshitaka
	NRID 1000050727451 1000050727451 ORCID 0000-0001-9147-8058 0000-0001-9147-8058 researchmap permalink y-kimura_neurol y-kimura_neurol Scopus Author ID 56673363900 56673363900 著者名 Kimura, Yasuyoshi
	著者名 Asai, Kanako
	著者名 Kudo, Haruka
	NRID 1000020534879 1000020534879 ORCID 0000-0001-8726-978X 0000-0001-8726-978X researchmap permalink tsutomusasaki1111 tsutomusasaki1111 Scopus Author ID 7407394272 7407394272 著者名 Sasaki, Tsutomu
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 著者名 Mochizuki, Hideki
	NRID 1000080501824 1000080501824 著者名 Miyashiro, Isao
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 著者名 Sobue, Tomotaka
キーワード等	cancer
	survivor
	non-cancer-related mortality
	cohort study
内容	Gon Yasufumi, Zha Ling, Morishima Toshitaka, et al. Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan. Journal of Epidemiology 35, 147 (2025); https://doi.org/10.2188/jea.JE20240230.
抄録	Background: Advancements in cancer care have improved survivorship, potentially leading to changes in mortality causes. This study aimed to investigate the causes of death among cancer survivors, specially focusing on non-cancer-related mortality. Methods: This nationwide population-based cohort study analyzed the causes of death based on the time since cancer diagnosis using data from the National Cancer Registry in Japan between January 2016 and December 2019. Non-cancer-related deaths were identified, and mortality risks associated with non-cancer diseases were compared to those of the Japanese general population using standardized mortality ratios (SMRs) with 95% confidence intervals (CIs). The follow-up period was up to 4 years after cancer diagnosis. Results: A total of 3,990,661 patients (45.8% women) were included in the analysis, yielding 6,237,269 person-years of follow-up. Of these, 1,001,857 (25.1%) patients died during the study period. Cancer-related and non-cancer-related causes accounted for 86.6% and 13.4% of deaths, respectively. The proportion of non-cancer-related deaths increased from 10.2% at 6 months to 31.6% at 4 years after cancer diagnosis. Heart disease (21.8%), cerebrovascular disease (9.8%), and pneumonia (9.1%) were the leading cause of non-cancer-related deaths: the SMRs for these diseases were 2.69 (95% CI, 2.66–2.72), 2.07 (95% CI, 2.03–2.10), and 2.41 (95% CI, 2.36–2.45), respectively. The SMR for suicide was 1.81 (95% CI, 1.74–1.89); however, it lost significance in males and females 2 and 2.5 years after cancer diagnosis, respectively. Conclusion: The proportion of non-cancer-related deaths among cancer patients has increased over time, emphasizing the need to manage cancer and its comorbidities carefully.
出版者	Japan Epidemiological Association
収録物名	Journal of Epidemiology
巻(号)	35(3)
ページ	147-153
刊行年月	2025-03-05
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100601
PISSN	09175040
eISSN	13499092
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.2188/jea.JE20240230
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Journal of Epidemiology. 2025, 35(3), p. 147-153
DC.title	Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan
DC.creator	Gon, Yasufumi
	Zha, Ling
	Morishima, Toshitaka
	Kimura, Yasuyoshi
	Asai, Kanako
	Kudo, Haruka
	Sasaki, Tsutomu
	Mochizuki, Hideki
	Miyashiro, Isao
	Sobue, Tomotaka
DC.publisher	Japan Epidemiological Association
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-03-05
DC.identifier	https://doi.org/10.2188/jea.JE20240230
DC.subject	cancer
	survivor
	non-cancer-related mortality
	cohort study
DC.description	Gon Yasufumi, Zha Ling, Morishima Toshitaka, et al. Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan. Journal of Epidemiology 35, 147 (2025); https://doi.org/10.2188/jea.JE20240230.
DCTERMS.abstract	Background: Advancements in cancer care have improved survivorship, potentially leading to changes in mortality causes. This study aimed to investigate the causes of death among cancer survivors, specially focusing on non-cancer-related mortality. Methods: This nationwide population-based cohort study analyzed the causes of death based on the time since cancer diagnosis using data from the National Cancer Registry in Japan between January 2016 and December 2019. Non-cancer-related deaths were identified, and mortality risks associated with non-cancer diseases were compared to those of the Japanese general population using standardized mortality ratios (SMRs) with 95% confidence intervals (CIs). The follow-up period was up to 4 years after cancer diagnosis. Results: A total of 3,990,661 patients (45.8% women) were included in the analysis, yielding 6,237,269 person-years of follow-up. Of these, 1,001,857 (25.1%) patients died during the study period. Cancer-related and non-cancer-related causes accounted for 86.6% and 13.4% of deaths, respectively. The proportion of non-cancer-related deaths increased from 10.2% at 6 months to 31.6% at 4 years after cancer diagnosis. Heart disease (21.8%), cerebrovascular disease (9.8%), and pneumonia (9.1%) were the leading cause of non-cancer-related deaths: the SMRs for these diseases were 2.69 (95% CI, 2.66–2.72), 2.07 (95% CI, 2.03–2.10), and 2.41 (95% CI, 2.36–2.45), respectively. The SMR for suicide was 1.81 (95% CI, 1.74–1.89); however, it lost significance in males and females 2 and 2.5 years after cancer diagnosis, respectively. Conclusion: The proportion of non-cancer-related deaths among cancer patients has increased over time, emphasizing the need to manage cancer and its comorbidities carefully.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100601
citation_title	Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan
citation_author	Gon, Yasufumi
	Zha, Ling
	Morishima, Toshitaka
	Kimura, Yasuyoshi
	Asai, Kanako
	Kudo, Haruka
	Sasaki, Tsutomu
	Mochizuki, Hideki
	Miyashiro, Isao
	Sobue, Tomotaka
citation_publisher	Japan Epidemiological Association
citation_language	英語
citation_date	2025-03-05
citation_journal_title	Journal of Epidemiology
citation_volume	35
citation_issue	3
citation_firstpage	147
citation_lastpage	153
citation_doi	https://doi.org/10.2188/jea.JE20240230
citation_public_url	https://hdl.handle.net/11094/100601

Non-cancer-related Deaths in Cancer Survivors: A Nationwide Population-based Study in Japan

閲覧可能ファイル

論文情報

論文詳細を表示