Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan

Suenaga, Risa; Komuro, Yuzu; Terao, Ken

doi:https://doi.org/10.1016/j.carbpol.2025.123504

Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan

Suenaga, Risa; Komuro, Yuzu; Terao, Ken

Carbohydrate Polymers, 2025, 358, 123504

アクセス数:102件（2025-10-25 14:04 集計）

固定URL: https://hdl.handle.net/11094/100612

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タイトル	Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan
著者	著者名 Suenaga, Risa
	著者名 Komuro, Yuzu
	NRID 1000060334132 1000060334132 ORCID 0000-0001-7363-4491 0000-0001-7363-4491 researchmap permalink kenterao kenterao Scopus Author ID 7101653015 7101653015 著者名 Terao, Ken
キーワード等	Amphiphilic polysaccharide derivative
	Pullulan
	Flower micelle
	Small-angle X-ray scattering
	Light scattering
内容	Suenaga Risa, Komuro Yuzu, Terao Ken. Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan. Carbohydrate Polymers 358, 123504 (2025); https://doi.org/10.1016/j.carbpol.2025.123504.
抄録	A pullulan-based polymeric micelle was obtained by modifying pullulan with decyl succinic anhydride (PulDS) to achieve a degree of substitution ranging from 0.46 to 0.72. SEC-MALS, static and dynamic light scattering, small angle X-ray scattering (SAXS), and fluorescence measurements were performed to characterize the micelle structure of PulDS in 25 mM aqueous NaCl at two different pH of 7 and 10. The scattering and fluorescence data clearly showed that the PulDS is molecularly dispersed as flower necklace micelles in the aqueous solvents. The size distribution of the unit micelles is significantly narrower than that of the previously investigated succinic anhydride modified pullulan. The resulting unit micelle size was found to depend less on chain length and degree of substitution, but the unit flower micelle was larger at pH 7 than at pH 10, suggesting that excess ionized OH groups on the glycosidic ring provide repulsive forces between the polymer chains. These features, namely the well-defined micelle structure and high solubility in aqueous media without large aggregates, indicate potential applications in drug delivery systems and as food additives.
出版者	Elsevier BV
収録物名	Carbohydrate Polymers
巻(号)	358
ページ	123504
刊行年月	2025-06-15
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100612
PISSN	01448617
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.carbpol.2025.123504
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Carbohydrate Polymers. 2025, 358, p. 123504
DC.title	Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan
DC.creator	Suenaga, Risa
	Komuro, Yuzu
	Terao, Ken
DC.publisher	Elsevier BV
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-06-15
DC.identifier	https://doi.org/10.1016/j.carbpol.2025.123504
DC.subject	Amphiphilic polysaccharide derivative
	Pullulan
	Flower micelle
	Small-angle X-ray scattering
	Light scattering
DC.description	Suenaga Risa, Komuro Yuzu, Terao Ken. Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan. Carbohydrate Polymers 358, 123504 (2025); https://doi.org/10.1016/j.carbpol.2025.123504.
DCTERMS.abstract	A pullulan-based polymeric micelle was obtained by modifying pullulan with decyl succinic anhydride (PulDS) to achieve a degree of substitution ranging from 0.46 to 0.72. SEC-MALS, static and dynamic light scattering, small angle X-ray scattering (SAXS), and fluorescence measurements were performed to characterize the micelle structure of PulDS in 25 mM aqueous NaCl at two different pH of 7 and 10. The scattering and fluorescence data clearly showed that the PulDS is molecularly dispersed as flower necklace micelles in the aqueous solvents. The size distribution of the unit micelles is significantly narrower than that of the previously investigated succinic anhydride modified pullulan. The resulting unit micelle size was found to depend less on chain length and degree of substitution, but the unit flower micelle was larger at pH 7 than at pH 10, suggesting that excess ionized OH groups on the glycosidic ring provide repulsive forces between the polymer chains. These features, namely the well-defined micelle structure and high solubility in aqueous media without large aggregates, indicate potential applications in drug delivery systems and as food additives.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100612
citation_title	Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan
citation_author	Suenaga, Risa
	Komuro, Yuzu
	Terao, Ken
citation_publisher	Elsevier BV
citation_language	英語
citation_date	2025-06-15
citation_journal_title	Carbohydrate Polymers
citation_volume	358
citation_firstpage	123504
citation_doi	https://doi.org/10.1016/j.carbpol.2025.123504
citation_public_url	https://hdl.handle.net/11094/100612

Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan

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