Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device

Murakami, Takashi; Misumi, Yusuke; Yoshioka, Daisuke; Kawamura, Takuji; Kawamura, Ai; Yajima, Shin; Saito, Shunsuke; Yamauchi, Takashi; Miyagawa, Shigeru

doi:https://doi.org/10.1111/aor.14987

Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device

Murakami, Takashi; Misumi, Yusuke; Yoshioka, Daisuke et al.

Artificial Organs, 2025

アクセス数:1,013件（2025-07-22 20:50 集計）

固定URL: https://hdl.handle.net/11094/100961

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タイトル	Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device
著者	著者名 Murakami, Takashi
	NRID 1000020631477 1000020631477 researchmap permalink yusukemisumi yusukemisumi 著者名 Misumi, Yusuke
	著者名 Yoshioka, Daisuke
	NRID 1000060839398 1000060839398 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 著者名 Kawamura, Takuji
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 著者名 Kawamura, Ai
	著者名 Yajima, Shin
	著者名 Saito, Shunsuke
	NRID 1000020527999 1000020527999 著者名 Yamauchi, Takashi
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 著者名 Miyagawa, Shigeru
キーワード等	aortic root morphology
	continuous-flow left ventricular assist device
	de novo aortic valve insufficiency
内容	Murakami T., Misumi Y., Yoshioka D., et al. Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device. Artificial Organs , (2025); https://doi.org/10.1111/aor.14987.
抄録	Background: The development of aortic valve regurgitation (AR) negatively affects the survival of patients with continuous-flow left ventricular assist device (LVAD) support. Although several risk factors have been identified, little is known about the effect of preoperative aortic root and valve morphology on the development of de novo AR after LVAD implantation. Methods: Between April 2018 and September 2023, 87 patients underwent durable LVAD implantation at our department. Of these, the 15 eligible patients who underwent preoperative electrocardiography-synchronized cardiac contrast-enhanced computed tomography were included in this study. Baseline aortic root and valve morphology and its relationship with the postoperative development of AR were retrospectively reviewed. Results: The mean duration of LVAD support was 1208 ± 618 days. At 60 months postsurgery, 10 patients had mild or greater AR (Group I) and the others did not (Group N). The measurement of baseline aortic root morphology showed that the ratio of virtual basal ring diameter to geometric height (VBD/GH) was significantly larger for Group I (1.70 ± 0.024 vs. 1.48 ± 0.034; p = 0.0001). Conclusions: A large preoperative VBD/GH is a significant risk factor for de novo AR. This finding may assist in determining the surgical indications for concomitant aortic valve procedures with durable LVAD implantation.
出版者	John Wiley and Sons Inc
収録物名	Artificial Organs
刊行年月	2025-03-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100961
PISSN	0160564X
eISSN	15251594
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/aor.14987
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Artificial Organs. 2025
DC.title	Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device
DC.creator	Murakami, Takashi
	Misumi, Yusuke
	Yoshioka, Daisuke
	Kawamura, Takuji
	Kawamura, Ai
	Yajima, Shin
	Saito, Shunsuke
	Yamauchi, Takashi
	Miyagawa, Shigeru
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-03-12
DC.identifier	https://doi.org/10.1111/aor.14987
DC.subject	aortic root morphology
	continuous-flow left ventricular assist device
	de novo aortic valve insufficiency
DC.description	Murakami T., Misumi Y., Yoshioka D., et al. Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device. Artificial Organs , (2025); https://doi.org/10.1111/aor.14987.
DCTERMS.abstract	Background: The development of aortic valve regurgitation (AR) negatively affects the survival of patients with continuous-flow left ventricular assist device (LVAD) support. Although several risk factors have been identified, little is known about the effect of preoperative aortic root and valve morphology on the development of de novo AR after LVAD implantation. Methods: Between April 2018 and September 2023, 87 patients underwent durable LVAD implantation at our department. Of these, the 15 eligible patients who underwent preoperative electrocardiography-synchronized cardiac contrast-enhanced computed tomography were included in this study. Baseline aortic root and valve morphology and its relationship with the postoperative development of AR were retrospectively reviewed. Results: The mean duration of LVAD support was 1208 ± 618 days. At 60 months postsurgery, 10 patients had mild or greater AR (Group I) and the others did not (Group N). The measurement of baseline aortic root morphology showed that the ratio of virtual basal ring diameter to geometric height (VBD/GH) was significantly larger for Group I (1.70 ± 0.024 vs. 1.48 ± 0.034; p = 0.0001). Conclusions: A large preoperative VBD/GH is a significant risk factor for de novo AR. This finding may assist in determining the surgical indications for concomitant aortic valve procedures with durable LVAD implantation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100961
citation_title	Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device
citation_author	Murakami, Takashi
	Misumi, Yusuke
	Yoshioka, Daisuke
	Kawamura, Takuji
	Kawamura, Ai
	Yajima, Shin
	Saito, Shunsuke
	Yamauchi, Takashi
	Miyagawa, Shigeru
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2025-03-12
citation_journal_title	Artificial Organs
citation_doi	https://doi.org/10.1111/aor.14987
citation_public_url	https://hdl.handle.net/11094/100961

Association of Aortic Root and Valve Morphology With De Novo Aortic Valve Regurgitation After Implantation of Left Ventricular Assist Device

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