d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection

Kimura, Tomonori; Sakai, Shinsuke; Isaka, Yoshitaka

ChemBioChem, 2025, e202500018

アクセス数:469件（2025-09-12 08:47 集計）

固定URL: https://hdl.handle.net/11094/100962

閲覧可能ファイル 

ファイル フォーマット 利用条件 サイズ 閲覧回数 利用開始日 説明 information
ChemBioChem pdf なし 2.13 MB 25 2025.04.15  
Creative Commons : 表示 - 非営利

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル
d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection
著者
NRID
1000000631300 1000000631300
ORCID
0000-0001-8186-094X 0000-0001-8186-094X
researchmap permalink
KimuraUNM KimuraUNM
Scopus Author ID
57199363473 57199363473
著者名
Kimura, Tomonori
NRID
1000060817360 1000060817360
著者名
Sakai, Shinsuke
NRID
1000000379166 1000000379166
researchmap permalink
isaka-handai3857 isaka-handai3857
Scopus Author ID
16207611100 16207611100
ORCID
0000-0002-0820-7167 0000-0002-0820-7167
著者名
Isaka, Yoshitaka
キーワード等
Circadian rhythm
d-Alanine
d-Amino acids
Glucose metabolism
Viral infection
内容
Kimura T., Sakai S., Isaka Y.. d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection. ChemBioChem , (2025); https://doi.org/10.1002/cbic.202500018.
抄録
d-Alanine, a rare d-amino acid, exhibits a clear circadian rhythm and is present in organs associated with glucose metabolism. Recent findings have revealed that d-alanine acts on the circadian rhythm, thereby regulating physiological processes related to circadian cycles that are essential for maintaining body homeostasis. The regulation of circadian rhythm by d-alanine is vital for correcting blood glucose levels in diabetic conditions. In viral infections, d-alanine serves as a sensitive biomarker that reflects the severity of the infection, as its level drastically decreases due to consumption. Supplementation with d-alanine is effective to alleviate the progression of viral infections, potentially through the maintenance of the circadian rhythm and its associated immune responses. In addition to its role as a circadian biomarker, d-alanine also functions as a circadian regulator and exerts a wide range of physiological effects. This review summarizes the physiological roles of d-alanine as a circadian metabolite.
出版者
John Wiley and Sons Inc
収録物名
ChemBioChem
ページ
e202500018
刊行年月
2025-02-18
言語
英語
ハンドルURL
https://hdl.handle.net/11094/100962
PISSN
14394227
eISSN
14397633
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/cbic.202500018
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article