Decarboxylative Functionalization of Carboxylic Acids with Easily Oxidizable, Unstable, and Difficult Substituents Under Visible Light Irradiation

Tamaki, Sota; Kusamoto, Tetsuro; Tsurugi, Hayato

ChemCatChem, 2025, e202402106

アクセス数:344件（2025-07-19 11:24 集計）

固定URL: https://hdl.handle.net/11094/100964

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タイトル
Decarboxylative Functionalization of Carboxylic Acids with Easily Oxidizable, Unstable, and Difficult Substituents Under Visible Light Irradiation
著者
著者名
Tamaki, Sota
NRID
1000090585192 1000090585192
ORCID
0000-0001-8391-4526 0000-0001-8391-4526
researchmap permalink
kusamoto_tetsuro kusamoto_tetsuro
著者名
Kusamoto, Tetsuro
NRID
1000060432514 1000060432514
ORCID
0000-0003-2942-7705 0000-0003-2942-7705
researchmap permalink
h_tsu h_tsu
Scopus Author ID
6505993971 6505993971
著者名
Tsurugi, Hayato
キーワード等
Carboxylic acids
Decarboxylation
Radical
Transition-metal catalysis
Visible light
内容
Tamaki S., Kusamoto T., Tsurugi H.. Decarboxylative Functionalization of Carboxylic Acids with Easily Oxidizable, Unstable, and Difficult Substituents Under Visible Light Irradiation. ChemCatChem , (2025); https://doi.org/10.1002/cctc.202402106.
抄録
Decarboxylative functionalization of carboxylic acids via carboxyl radical generation is an important strategy in organic synthesis. Carboxylic acids, widely found in nature as amino acids, peptides, fatty acids, and sugar acids, have the high abundance, accessibility, and stability. Decarboxylation of simple carboxylic acids such as acetic acid and fluoroalkyl carboxylic acids leads to the formation of synthetically useful methyl and fluoroalkyl radicals. The high stability of the carboxyl group toward air and moisture as well as the high functional group tolerance of radical reactions enable the application of aliphatic carboxylic acid functionalities in late-stage transformations during the synthesis of complicated organic molecules, such as natural products and pharmaceuticals. This review focuses on recent advancements in decarboxylative functionalization under visible light irradiation, highlighting carboxylic acids with easily oxidizable, unstable, and difficult substituents. In addition to visible-light-induced transformations, this review summarizes electrochemical and thermal reactions as complementary methods for decarboxylative transformations.
出版者
John Wiley and Sons Inc
収録物名
ChemCatChem
ページ
e202402106
刊行年月
2025-03-03
言語
英語
ハンドルURL
https://hdl.handle.net/11094/100964
PISSN
18673880
eISSN
18673899
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/cctc.202402106
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article