Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin

Obuse, Chikashi; Nakayama, Jun ichi

doi:https://doi.org/10.1016/j.bbagen.2025.130790

Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin

Obuse, Chikashi; Nakayama, Jun ichi

Biochimica et Biophysica Acta - General Subjects, 2025, 1869(6), 130790

アクセス数:112件（2025-06-19 11:22 集計）

固定URL: https://hdl.handle.net/11094/100978

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タイトル	Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin
著者	NRID 1000000273855 1000000273855 researchmap permalink obuse obuse Scopus Author ID 6701730728 6701730728 著者名 Obuse, Chikashi
著者	NRID 1000060373338 1000060373338 著者名 Nakayama, Jun ichi
キーワード等	Heterochromatin
	Histone modification
	Intrinsically disordered protein
	Liquid-liquid phase separation
	Non-coding RNA
内容	Obuse C., Nakayama J.i.. Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin. Biochimica et Biophysica Acta - General Subjects 1869, 130790 (2025); https://doi.org/10.1016/j.bbagen.2025.130790.
抄録	Heterochromatin is a highly condensed chromatin structure observed in the nuclei of eukaryotic cells. It plays a pivotal role in repressing undesired gene expression and establishing functional chromosomal domains, including centromeres and telomeres. Heterochromatin is characterized by specific histone modifications and the formation of higher-order chromatin structures mediated by proteins, such as HP1 and Polycomb repressive complexes (PRCs), which recognize the specific histone modifications. Recent studies have identified the involvement of non-coding RNAs (ncRNAs) and intrinsically disordered proteins (IDPs) in heterochromatin, leading to the proposal of a new model in which liquid-liquid phase separation (LLPS) contributes to heterochromatin formation and function. This emerging model not only broadens our understanding of heterochromatin's molecular mechanisms but also provides insights into its dynamic regulation depending on cellular context. Such advancements pave the way for exploring heterochromatin's role in genome organization and stability, as well as its implications in development and disease.
出版者	Elsevier B.V.
収録物名	Biochimica et Biophysica Acta - General Subjects
巻(号)	1869(6)
ページ	130790
刊行年月	2025-05-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/100978
PISSN	03044165
eISSN	18728006
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.bbagen.2025.130790
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Biochimica et Biophysica Acta - General Subjects. 2025, 1869(6), p. 130790
DC.title	Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin
DC.creator	Obuse, Chikashi
DC.creator	Nakayama, Jun ichi
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-01
DC.identifier	https://doi.org/10.1016/j.bbagen.2025.130790
DC.subject	Heterochromatin
	Histone modification
	Intrinsically disordered protein
	Liquid-liquid phase separation
	Non-coding RNA
DC.description	Obuse C., Nakayama J.i.. Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin. Biochimica et Biophysica Acta - General Subjects 1869, 130790 (2025); https://doi.org/10.1016/j.bbagen.2025.130790.
DCTERMS.abstract	Heterochromatin is a highly condensed chromatin structure observed in the nuclei of eukaryotic cells. It plays a pivotal role in repressing undesired gene expression and establishing functional chromosomal domains, including centromeres and telomeres. Heterochromatin is characterized by specific histone modifications and the formation of higher-order chromatin structures mediated by proteins, such as HP1 and Polycomb repressive complexes (PRCs), which recognize the specific histone modifications. Recent studies have identified the involvement of non-coding RNAs (ncRNAs) and intrinsically disordered proteins (IDPs) in heterochromatin, leading to the proposal of a new model in which liquid-liquid phase separation (LLPS) contributes to heterochromatin formation and function. This emerging model not only broadens our understanding of heterochromatin's molecular mechanisms but also provides insights into its dynamic regulation depending on cellular context. Such advancements pave the way for exploring heterochromatin's role in genome organization and stability, as well as its implications in development and disease.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	100978
citation_title	Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin
citation_author	Obuse, Chikashi
citation_author	Nakayama, Jun ichi
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2025-05-01
citation_journal_title	Biochimica et Biophysica Acta - General Subjects
citation_volume	1869
citation_issue	6
citation_firstpage	130790
citation_doi	https://doi.org/10.1016/j.bbagen.2025.130790
citation_public_url	https://hdl.handle.net/11094/100978

Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin

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