Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone

Ikuta, Masato; Harumningtyas, Anjar Anggraini; Ito, Tomoko; Fujita, Kenta; Kitahara, Takayuki; Bun, Masayuki; Furuichi, Takuya; Hirai, Hiromasa; Ukon, Yuichiro; Tateiwa, Daisuke; Kanie, Yuya; Furuya, Masayuki; Fujimori, Takahito; Okada, Seiji; Hamaguchi, Satoshi; Kaito, Takashi

doi:https://doi.org/10.1007/s42247-025-01033-8

Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone

Ikuta, Masato; Harumningtyas, Anjar Anggraini; Ito, Tomoko et al.

Emergent Materials, 2025

アクセス数:2,061件（2025-11-20 15:51 集計）

固定URL: https://hdl.handle.net/11094/101002

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タイトル	Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
著者	著者名 Ikuta, Masato
	著者名 Harumningtyas, Anjar Anggraini
	NRID 1000010724784 1000010724784 researchmap permalink plasma0326 plasma0326 著者名 Ito, Tomoko
	著者名 Fujita, Kenta
	著者名 Kitahara, Takayuki
	著者名 Bun, Masayuki
	著者名 Furuichi, Takuya
	著者名 Hirai, Hiromasa
	NRID 1000050964334 1000050964334 ORCID 0000-0002-0747-8854 0000-0002-0747-8854 researchmap permalink yuichiro.ukon yuichiro.ukon 著者名 Ukon, Yuichiro
	著者名 Tateiwa, Daisuke
	NRID 1000010896377 1000010896377 researchmap permalink ykanie1985 ykanie1985 著者名 Kanie, Yuya
	NRID 1000020987466 1000020987466 researchmap permalink furuya1019 furuya1019 著者名 Furuya, Masayuki
	NRID 1000080546888 1000080546888 researchmap permalink fujimori_takahito fujimori_takahito Scopus Author ID 35271904600 35271904600 著者名 Fujimori, Takahito
	NRID 1000030448435 1000030448435 ORCID 0000-0002-5107-8209 0000-0002-5107-8209 researchmap permalink okadaseiji okadaseiji Scopus Author ID 35079139100 35079139100 著者名 Okada, Seiji
	NRID 1000060301826 1000060301826 ORCID 0000-0001-6580-8797 0000-0001-6580-8797 researchmap permalink satoshi_hamaguchi satoshi_hamaguchi Scopus Author ID 55220082400 55220082400 著者名 Hamaguchi, Satoshi
	NRID 1000070623982 1000070623982 ORCID 0000-0003-4882-2997 0000-0003-4882-2997 researchmap permalink 911_0 911_0 Scopus Author ID 25824322100 25824322100 著者名 Kaito, Takashi
キーワード等	Magnetron sputtering
	Osseointegration
	Polyetheretherketone
	Strontium titanate
	Surface modification
内容	The version of record of this article, first published in Emergent Materials, is available online at Publisher’s website: https://doi.org/10.1007/s42247-025-01033-8
抄録	Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack of osseointegration capacity). Surface modification can impart bioactivity to PEEK while maintaining its mechanical properties. In this study, the surface of PEEK was modified with titanium or strontium titanate thin films formed by magnetron sputtering deposition. We evaluated the bone formation activity of strontium titanate-modified PEEK (PEEK-STO) by comparing three groups: unmodified PEEK (PEEK), titanium-modified PEEK (PEEK-Ti), and strontium titanate-modified PEEK (PEEK-STO). Osteogenic differentiation of cells, assessed by ALP activity, bone-related gene expression, and mineralization ability, demonstrated that PEEK-STO has the highest osteogenic activity. Furthermore, the evaluation of mineral deposition by non-cellular mechanisms using simulated body fluid showed that PEEK-Ti and PEEK-STO have higher calcium phosphate deposition capacity than PEEK. In vivo implantation of the materials into the rat femur demonstrated that bone-to-implant contact ratio (BIC%) and bone area ratio (BA%) in the proximity zone from the implant were significantly larger in PEEK-STO compared to PEEK-Ti and PEEK at 4 weeks post-surgery. This study demonstrates that surface modification of PEEK with strontium titanate through magnetron sputtering is an attractive option for solving the problems of PEEK’s biological inertness while making the most of the advantages of PEEK as a spinal fusion device.
出版者	Springer Nature
収録物名	Emergent Materials
刊行年月	2025-02-25
言語	英語
ハンドルURL	https://hdl.handle.net/11094/101002
PISSN	25225731
eISSN	2522574X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s42247-025-01033-8
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Emergent Materials. 2025
DC.title	Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
DC.creator	Ikuta, Masato
	Harumningtyas, Anjar Anggraini
	Ito, Tomoko
	Fujita, Kenta
	Kitahara, Takayuki
	Bun, Masayuki
	Furuichi, Takuya
	Hirai, Hiromasa
	Ukon, Yuichiro
	Tateiwa, Daisuke
	Kanie, Yuya
	Furuya, Masayuki
	Fujimori, Takahito
	Okada, Seiji
	Hamaguchi, Satoshi
	Kaito, Takashi
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-02-25
DC.identifier	https://doi.org/10.1007/s42247-025-01033-8
DC.subject	Magnetron sputtering
	Osseointegration
	Polyetheretherketone
	Strontium titanate
	Surface modification
DC.description	The version of record of this article, first published in Emergent Materials, is available online at Publisher’s website: https://doi.org/10.1007/s42247-025-01033-8
DCTERMS.abstract	Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack of osseointegration capacity). Surface modification can impart bioactivity to PEEK while maintaining its mechanical properties. In this study, the surface of PEEK was modified with titanium or strontium titanate thin films formed by magnetron sputtering deposition. We evaluated the bone formation activity of strontium titanate-modified PEEK (PEEK-STO) by comparing three groups: unmodified PEEK (PEEK), titanium-modified PEEK (PEEK-Ti), and strontium titanate-modified PEEK (PEEK-STO). Osteogenic differentiation of cells, assessed by ALP activity, bone-related gene expression, and mineralization ability, demonstrated that PEEK-STO has the highest osteogenic activity. Furthermore, the evaluation of mineral deposition by non-cellular mechanisms using simulated body fluid showed that PEEK-Ti and PEEK-STO have higher calcium phosphate deposition capacity than PEEK. In vivo implantation of the materials into the rat femur demonstrated that bone-to-implant contact ratio (BIC%) and bone area ratio (BA%) in the proximity zone from the implant were significantly larger in PEEK-STO compared to PEEK-Ti and PEEK at 4 weeks post-surgery. This study demonstrates that surface modification of PEEK with strontium titanate through magnetron sputtering is an attractive option for solving the problems of PEEK’s biological inertness while making the most of the advantages of PEEK as a spinal fusion device.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	101002
citation_title	Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
citation_author	Ikuta, Masato
	Harumningtyas, Anjar Anggraini
	Ito, Tomoko
	Fujita, Kenta
	Kitahara, Takayuki
	Bun, Masayuki
	Furuichi, Takuya
	Hirai, Hiromasa
	Ukon, Yuichiro
	Tateiwa, Daisuke
	Kanie, Yuya
	Furuya, Masayuki
	Fujimori, Takahito
	Okada, Seiji
	Hamaguchi, Satoshi
	Kaito, Takashi
citation_publisher	Springer Nature
citation_language	英語
citation_date	2025-02-25
citation_journal_title	Emergent Materials
citation_doi	https://doi.org/10.1007/s42247-025-01033-8
citation_public_url	https://hdl.handle.net/11094/101002

Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone

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