Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath

Omura, Akiisa; Kimura, Toru; Maniwa, Tomohiro; Watabe, Tadashi; Honma, Keiichiro; Shintani, Yasushi; Okami, Jiro

doi:https://doi.org/10.1007/s00595-025-03024-y

Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath

Omura, Akiisa; Kimura, Toru; Maniwa, Tomohiro et al.

Surgery Today, 2025, 155380

アクセス数:911件（2025-07-28 14:43 集計）

固定URL: https://hdl.handle.net/11094/101012

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タイトル	Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
著者	著者名 Omura, Akiisa
	NRID 1000090580796 1000090580796 ORCID 0000-0003-4504-232X 0000-0003-4504-232X researchmap permalink toru_kimura toru_kimura 著者名 Kimura, Toru
	著者名 Maniwa, Tomohiro
	NRID 1000090648932 1000090648932 ORCID 0000-0001-8658-2395 0000-0001-8658-2395 researchmap permalink twosaka2018 twosaka2018 Scopus Author ID 57421862900 57421862900 著者名 Watabe, Tadashi
	NRID 1000020505945 1000020505945 著者名 Honma, Keiichiro
	NRID 1000090572983 1000090572983 researchmap permalink shintani6384 shintani6384 Scopus Author ID 7103142734 7103142734 著者名 Shintani, Yasushi
	NRID 1000040538857 1000040538857 著者名 Okami, Jiro
キーワード等	Diagnostic target
	Fibroblast activation protein
	Malignant potential
	Pleural tumor
	Solitary fibrous tumor
内容	The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: https://doi.org/10.1007/s00595-025-03024-y
抄録	Purpose: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs. Methods: The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath. Results: Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP. Conclusion: Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.
出版者	Springer
収録物名	Surgery Today
ページ	155380
刊行年月	2025-03-24
言語	英語
ハンドルURL	https://hdl.handle.net/11094/101012
PISSN	09411291
eISSN	14362813
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s00595-025-03024-y
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Surgery Today. 2025, p. 155380
DC.title	Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
DC.creator	Omura, Akiisa
	Kimura, Toru
	Maniwa, Tomohiro
	Watabe, Tadashi
	Honma, Keiichiro
	Shintani, Yasushi
	Okami, Jiro
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-03-24
DC.identifier	https://doi.org/10.1007/s00595-025-03024-y
DC.subject	Diagnostic target
	Fibroblast activation protein
	Malignant potential
	Pleural tumor
	Solitary fibrous tumor
DC.description	The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: https://doi.org/10.1007/s00595-025-03024-y
DCTERMS.abstract	Purpose: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs. Methods: The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath. Results: Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP. Conclusion: Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	101012
citation_title	Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
citation_author	Omura, Akiisa
	Kimura, Toru
	Maniwa, Tomohiro
	Watabe, Tadashi
	Honma, Keiichiro
	Shintani, Yasushi
	Okami, Jiro
citation_publisher	Springer
citation_language	英語
citation_date	2025-03-24
citation_journal_title	Surgery Today
citation_firstpage	155380
citation_doi	https://doi.org/10.1007/s00595-025-03024-y
citation_public_url	https://hdl.handle.net/11094/101012

Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath

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