Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury

Ito, Hiroshi; Ebihara, Takeshi; Matsumoto, Hisatake et al.

Scientific Reports, 2025, 15(1), 2470

アクセス数:782件（2025-07-28 13:55 集計）

固定URL: https://hdl.handle.net/11094/101050

閲覧可能ファイル 

ファイル フォーマット 利用条件 サイズ 閲覧回数 利用開始日 説明 information
SciRep_15_1_2470 pdf なし 1.69 MB 20 2025.04.18  
Creative Commons : 表示 - 非営利 - 改変禁止

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル
Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury
著者
NRID
1000080836594 1000080836594
researchmap permalink
1009hiroshi.ito 1009hiroshi.ito
著者名
Ito, Hiroshi
NRID
1000010813975 1000010813975
ORCID
0000-0003-4101-0419 0000-0003-4101-0419
researchmap permalink
ebihara830 ebihara830
著者名
Ebihara, Takeshi
NRID
1000070644003 1000070644003
researchmap permalink
38283828 38283828
Scopus Author ID
36632584800 36632584800
著者名
Matsumoto, Hisatake
NRID
1000060459500 1000060459500
ORCID
0000-0002-8254-3716 0000-0002-8254-3716
researchmap permalink
read0068529 read0068529
Scopus Author ID
56210537000 56210537000
著者名
Oda, Jun
キーワード等
Growth differentiation factor 15
Sequential organ failure assessment score
Traumatic brain injury
内容
Ito H., Ebihara T., Matsumoto H., et al. Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury. Scientific Reports 15, 2470 (2025); https://doi.org/10.1038/s41598-025-87062-z.
抄録
Circulating growth differentiation factor 15 (GDF-15) increases in response to inflammation and tissue damage. Its association with functional prognosis in cerebral infarction and subarachnoid hemorrhage is established; however, its role in traumatic brain injury (TBI) and its relationship with Sequential Organ Failure Assessment (SOFA) score, an indicator of systemic organ damage in TBI, remains unclear. This study aimed to explore the correlation between GDF-15 and functional outcomes at discharge in patients with TBI and stroke, including its association with SOFA scores in TBI. Patients with cerebral infarction, subarachnoid hemorrhage, and TBI transported within 24 h from July 2020 to August 2022 were included. Multivariable logistic regression analyzed the relationship between GDF-15 levels at admission and functional outcomes at discharge, with age and sex as covariates. Additionally, correlations between GDF-15 levels and SOFA scores were assessed. Multivariable logistic regression showed a relationship between GDF-15 levels at admission and functional outcomes at discharge in cerebral infarction and subarachnoid hemorrhage but not in TBI. In TBI cases, GDF-15 correlated with SOFA scores, indicating its potential as a TBI severity marker. Although functional prognosis at discharge was evaluated, long-term outcomes were not clear, and this will be addressed in future research.
出版者
Nature Research
収録物名
Scientific Reports
巻(号)
15(1)
ページ
2470
刊行年月
2025-01-20
言語
英語
ハンドルURL
https://hdl.handle.net/11094/101050
eISSN
20452322
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1038/s41598-025-87062-z
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article