Heritability of bone mineral density among Japanese women: A twin study

Saeki, Soichiro; Tomizawa, Rie; Minamitani, Kaori; Nakata, Ken; Honda, Chika

doi:https://doi.org/10.1016/j.maturitas.2025.108251

Heritability of bone mineral density among Japanese women: A twin study

Saeki, Soichiro; Tomizawa, Rie; Minamitani, Kaori et al.

Maturitas, 2025, 196, 108251

アクセス数:301件（2025-08-29 15:44 集計）

固定URL: https://hdl.handle.net/11094/101345

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タイトル	Heritability of bone mineral density among Japanese women: A twin study
著者	著者名 Saeki, Soichiro
	NRID 1000020584551 1000020584551 著者名 Tomizawa, Rie
	NRID 1000000571423 1000000571423 著者名 Minamitani, Kaori
	NRID 1000000283747 1000000283747 researchmap permalink ken-nakata ken-nakata Scopus Author ID 7402151308 7402151308 著者名 Nakata, Ken
	NRID 1000040625498 1000040625498 著者名 Honda, Chika
キーワード等	Bone fractures
	Bone mineral density
	Heritability
	Osteoporosis
	Prevention
	Race and ethnicity
内容	Saeki S., Tomizawa R., Minamitani K., et al. Heritability of bone mineral density among Japanese women: A twin study. Maturitas 196, 108251 (2025); https://doi.org/10.1016/j.maturitas.2025.108251.
抄録	Background: Osteoporosis is a major risk factor for fractures among the older population. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored. Therefore, we conducted a twin study among Japanese women to determine the extent of genetic and environmental influences on bone mineral density. Methods: The bone area ratio of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density. Results: The heritability of bone mineral density for the entire cohort was 0.51 (95 % confidence interval 0.38–0.63). For the women younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the additive genetics and unique environment (AE) model, with a heritability estimate of 0.53 (95 % confidence interval 0.34–0.72). Conclusions: Compared with women from other countries, Japanese women appear to have a lower heritability of bone mineral density. Consequently, environmental factors may exert a larger influence on osteoporosis among Japanese women than among women of other races and ethnicities.
出版者	Elsevier Ireland Ltd
収録物名	Maturitas
巻(号)	196
ページ	108251
刊行年月	2025-03-27
言語	英語
ハンドルURL	https://hdl.handle.net/11094/101345
PISSN	03785122
eISSN	18734111
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.maturitas.2025.108251
アクセス権	embargoed access
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報	The full-text file will be made open to the public on 27 March 2026 in accordance with the publisher's policy.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Maturitas. 2025, 196, p. 108251
DC.title	Heritability of bone mineral density among Japanese women: A twin study
DC.creator	Saeki, Soichiro
	Tomizawa, Rie
	Minamitani, Kaori
	Nakata, Ken
	Honda, Chika
DC.publisher	Elsevier Ireland Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-03-27
DC.identifier	https://doi.org/10.1016/j.maturitas.2025.108251
DC.subject	Bone fractures
	Bone mineral density
	Heritability
	Osteoporosis
	Prevention
	Race and ethnicity
DC.description	Saeki S., Tomizawa R., Minamitani K., et al. Heritability of bone mineral density among Japanese women: A twin study. Maturitas 196, 108251 (2025); https://doi.org/10.1016/j.maturitas.2025.108251.
DCTERMS.abstract	Background: Osteoporosis is a major risk factor for fractures among the older population. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored. Therefore, we conducted a twin study among Japanese women to determine the extent of genetic and environmental influences on bone mineral density. Methods: The bone area ratio of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density. Results: The heritability of bone mineral density for the entire cohort was 0.51 (95 % confidence interval 0.38–0.63). For the women younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the additive genetics and unique environment (AE) model, with a heritability estimate of 0.53 (95 % confidence interval 0.34–0.72). Conclusions: Compared with women from other countries, Japanese women appear to have a lower heritability of bone mineral density. Consequently, environmental factors may exert a larger influence on osteoporosis among Japanese women than among women of other races and ethnicities.
DC.rights	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.rights	The full-text file will be made open to the public on 27 March 2026 in accordance with the publisher's policy.
DC.format	101345
citation_title	Heritability of bone mineral density among Japanese women: A twin study
citation_author	Saeki, Soichiro
	Tomizawa, Rie
	Minamitani, Kaori
	Nakata, Ken
	Honda, Chika
citation_publisher	Elsevier Ireland Ltd
citation_language	英語
citation_date	2025-03-27
citation_journal_title	Maturitas
citation_volume	196
citation_firstpage	108251
citation_doi	https://doi.org/10.1016/j.maturitas.2025.108251
citation_public_url	https://hdl.handle.net/11094/101345

Heritability of bone mineral density among Japanese women: A twin study

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