Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer

Hara, Tomoaki; Meng, Sikun; Arao, Yasuko et al.

Cancer Medicine, 2025, 14(11), e70934

アクセス数:6件（2025-08-15 07:42 集計）

固定URL: https://hdl.handle.net/11094/102236

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タイトル
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer
著者
NRID
1000030779161 1000030779161
researchmap permalink
registered20221012 registered20221012
著者名
Hara, Tomoaki
NRID
1000050977204 1000050977204
researchmap permalink
sikunmeng sikunmeng
著者名
Meng, Sikun
NRID
1000070962736 1000070962736
著者名
Arao, Yasuko
著者名
Saito, Yoshiko
著者名
Inoue, Kana
著者名
Rennie, Sarah
著者名
Ofusa, Ken
NRID
1000040314322 1000040314322
researchmap permalink
torumd torumd
著者名
Kitagawa, Toru
NRID
1000010280736 1000010280736
researchmap permalink
read0103186 read0103186
Scopus Author ID
7402978600 7402978600
著者名
Ishii, Hideshi
キーワード等
m6A
METTL3
pancreatic cancer
RNA modifications
TCEAL8
内容
Hara T., Meng S., Arao Y., et al. Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer. Cancer Medicine 14, e70934 (2025); https://doi.org/10.1002/cam4.70934.
抄録
Background: RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1-methyladenosine (m¹A), N6-methyladenosine (m⁶A), N3-methylcytosine (m³C), 5-methylcytosine (m⁵C), 7-methylguanosine (m⁷G), and N4-acetylcytidine (ac⁴C) have been reported as RNA modifications affecting gene expression. Aim: In this review, the function of m⁶A in pancreatic cancer is mainly described, and the current status and prospects of RNA modifications are discussed. Methodology: We summarize recent reports on m⁶A writers METTL3, METTL5, METTL14, and METTL16; m⁶A readers IGF2BP1, IGF2BP2, IGF2BP3, YTHDF1, YTHDF2, and YTHDF3; and m⁶A erasers ALKBH5 and FTO. Results: RNA modifications are written to the RNA by the writer, and the reader binds to the RNA modification, causing gene expression to increase or decrease. Gene expression is also regulated by the removal of RNA modifications by the eraser. Moreover, our recent investigation into m⁶A modifications in pancreatic cancer has led to the identification of several promising candidate biomarkers, highlighting the potential role of epitranscriptomic regulation in tumorigenesis. Conclusion: These findings suggest that further exploration of RNA modification functions may facilitate the identification of novel biomarker and therapeutic target molecules for pancreatic cancer.
出版者
John Wiley and Sons Inc
収録物名
Cancer Medicine
巻(号)
14(11)
ページ
e70934
刊行年月
2025-03-25
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102236
eISSN
20457634
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/cam4.70934
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article