KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice

Kitakaze, Hiroaki; Miyata, Haruhiko; Oyama, Yuki et al.

Reproductive Medicine and Biology, 2025, 24(1), e12659

アクセス数:19件（2025-07-28 05:16 集計）

固定URL: https://hdl.handle.net/11094/102237

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タイトル
KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice
著者
NRID
1000050981958 1000050981958
researchmap permalink
hiroakikitakaze hiroakikitakaze
著者名
Kitakaze, Hiroaki
NRID
1000050604732 1000050604732
ORCID
0000-0003-4758-5803 0000-0003-4758-5803
researchmap permalink
hmiyata hmiyata
Scopus Author ID
37161837000 37161837000
著者名
Miyata, Haruhiko
著者名
Oyama, Yuki
著者名
Pan, Chen
著者名
Kujime, Yuma
著者名
Tsujimura, Go
著者名
Imanaka, Takahiro
著者名
Kuribayashi, Sohei
NRID
1000040759528 1000040759528
researchmap permalink
090 090
著者名
Ueda, Norichika
NRID
1000090648015 1000090648015
ORCID
0000-0003-1137-1846 0000-0003-1137-1846
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urouro urouro
Scopus Author ID
35171791000 35171791000
著者名
Takezawa, Kentaro
NRID
1000020609870 1000020609870
researchmap permalink
sf55 sf55
Scopus Author ID
8635237400 8635237400
著者名
Fukuhara, Shinichiro
NRID
1000030263263 1000030263263
researchmap permalink
read0185096 read0185096
Scopus Author ID
7005880662 7005880662
著者名
Nonomura, Norio
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
著者名
Ikawa, Masahito
キーワード等
KIF2C
knockout mice
male infertility
nonobstructive azoospermia
内容
Kitakaze H., Miyata H., Oyama Y., et al. KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice. Reproductive Medicine and Biology 24(1), e12659 (2025); https://doi.org/10.1002/rmb2.12659.
抄録
Purpose: Kinesin Family Member 2C (KIF2C) is a key regulator of microtubule dynamics and chromosome segregation in mitosis. However, its role in spermatogenesis remains unclear. Recent transcriptomic analyses suggest a potential link between KIF2C and male infertility. This study aimed to clarify KIF2C's roles in spermatogenesis using Kif2c knockout (KO) mice. Methods: To overcome the preweaning lethality associated with Kif2c deletion, we generated Kif2c KO mice with a mixed genetic background of 129X1/SvJ and B6D2. We assessed male fertility, epididymal sperm counts, and testicular sections of Kif2c KO mice. Results: Global Kif2c KO mice were obtained and showed male infertility. Histological analyses and epididymal sperm count revealed that Kif2c KO mice exhibited severely impaired spermatogenesis and absence of mature spermatozoa. These findings are consistent with those observed in patients with nonobstructive azoospermia (NOA). Our classification of Kif2c KO seminiferous tubules indicated that most spermatogenic cells were arrested at the early stages, particularly during meiosis. Conclusions: This study provides in vivo evidence that KIF2C is essential for spermatogenesis and male fertility in mice. The successful generation of global Kif2c KO mice establishes an animal model for NOA, supporting research on germ cell development and reproductive health.
出版者
John Wiley and Sons Ltd
収録物名
Reproductive Medicine and Biology
巻(号)
24(1)
ページ
e12659
刊行年月
2025-05-27
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102237
PISSN
14455781
eISSN
14470578
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/rmb2.12659
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article