Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

Kawamura, Takuji; Saito, Shunsuke; Taguchi, Takura; Yoshioka, Daisuke; Kawamura, Ai; Misumi, Yusuke; Yamauchi, Takashi; Miyagawa, Shuji; Miyagawa, Shigeru

doi:https://doi.org/10.1007/s10047-025-01504-z

Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

Kawamura, Takuji; Saito, Shunsuke; Taguchi, Takura et al.

Journal of Artificial Organs, 2025

アクセス数:4件（2025-07-22 21:06 集計）

固定URL: https://hdl.handle.net/11094/102244

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タイトル	Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation
著者	NRID 1000060839398 1000060839398 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 著者名 Kawamura, Takuji
	NRID 1000030600126 1000030600126 ORCID 0000-0002-0829-2891 0000-0002-0829-2891 researchmap permalink shunsaito shunsaito Scopus Author ID 57205524320 57205524320 著者名 Saito, Shunsuke
	著者名 Taguchi, Takura
	NRID 1000040645959 1000040645959 researchmap permalink d-yoshioka d-yoshioka Scopus Author ID 7003892845 7003892845 著者名 Yoshioka, Daisuke
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 著者名 Kawamura, Ai
	NRID 1000020631477 1000020631477 researchmap permalink yusukemisumi yusukemisumi 著者名 Misumi, Yusuke
	NRID 1000020527999 1000020527999 著者名 Yamauchi, Takashi
	NRID 1000090273648 1000090273648 researchmap permalink read0185079 read0185079 著者名 Miyagawa, Shuji
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 著者名 Miyagawa, Shigeru
キーワード等	Cardiac xenotransplantation
	End-stage heart failure
	Genetic engineering
	Pig
内容	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01504-z.
抄録	Cardiac xenotransplantation utilizing genetically modified pigs presents a promising avenue for treating end-stage heart failure, a leading cause of mortality worldwide. This paper delineates the current landscape of heart failure treatment in Japan, emphasizing the limitations of existing therapies such as heart transplantation and implantable left ventricular assist devices. It discusses the history and advancements in the development of genetically modified pigs for xenotransplantation, highlighting recent breakthroughs and challenges. The manuscript also addresses the specific challenges facing the implementation of xenotransplantation in Japan, including the selection of suitable genetically modified pigs, ensuring organ safety, patient selection criteria, transplantation protocols, and immunosuppression strategies. Drawing from international experiences and ongoing research efforts, the paper emphasizes the potential of xenotransplantation while acknowledging the hurdles that must be overcome for widespread clinical adoption.
出版者	Springer
収録物名	Journal of Artificial Organs
刊行年月	2025-05-04
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102244
PISSN	14347229
eISSN	16190904
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10047-025-01504-z
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Artificial Organs. 2025
DC.title	Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation
DC.creator	Kawamura, Takuji
	Saito, Shunsuke
	Taguchi, Takura
	Yoshioka, Daisuke
	Kawamura, Ai
	Misumi, Yusuke
	Yamauchi, Takashi
	Miyagawa, Shuji
	Miyagawa, Shigeru
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-04
DC.identifier	https://doi.org/10.1007/s10047-025-01504-z
DC.subject	Cardiac xenotransplantation
	End-stage heart failure
	Genetic engineering
	Pig
DC.description	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01504-z.
DCTERMS.abstract	Cardiac xenotransplantation utilizing genetically modified pigs presents a promising avenue for treating end-stage heart failure, a leading cause of mortality worldwide. This paper delineates the current landscape of heart failure treatment in Japan, emphasizing the limitations of existing therapies such as heart transplantation and implantable left ventricular assist devices. It discusses the history and advancements in the development of genetically modified pigs for xenotransplantation, highlighting recent breakthroughs and challenges. The manuscript also addresses the specific challenges facing the implementation of xenotransplantation in Japan, including the selection of suitable genetically modified pigs, ensuring organ safety, patient selection criteria, transplantation protocols, and immunosuppression strategies. Drawing from international experiences and ongoing research efforts, the paper emphasizes the potential of xenotransplantation while acknowledging the hurdles that must be overcome for widespread clinical adoption.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102244
citation_title	Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation
citation_author	Kawamura, Takuji
	Saito, Shunsuke
	Taguchi, Takura
	Yoshioka, Daisuke
	Kawamura, Ai
	Misumi, Yusuke
	Yamauchi, Takashi
	Miyagawa, Shuji
	Miyagawa, Shigeru
citation_publisher	Springer
citation_language	英語
citation_date	2025-05-04
citation_journal_title	Journal of Artificial Organs
citation_doi	https://doi.org/10.1007/s10047-025-01504-z
citation_public_url	https://hdl.handle.net/11094/102244

Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

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