Differences between xenotransplantation and allogeneic kidney transplantation: the current situation and future challenges in Japan

Matsumura, Soichi; Kakuta, Yoichi; Maegawa-Higa, Yoko; Fukae, Shota; Tanaka, Ryo; Nakazawa, Shigeaki; Yamanaka, Kazuaki; Miyagawa, Shuji; Nonomura, Norio

doi:https://doi.org/10.1007/s10047-025-01506-x

Differences between xenotransplantation and allogeneic kidney transplantation: the current situation and future challenges in Japan

Matsumura, Soichi; Kakuta, Yoichi; Maegawa-Higa, Yoko et al.

Journal of Artificial Organs, 2025

アクセス数:23件（2025-08-14 23:46 集計）

固定URL: https://hdl.handle.net/11094/102247

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タイトル	Differences between xenotransplantation and allogeneic kidney transplantation: the current situation and future challenges in Japan
著者	NRID 1000090981986 1000090981986 著者名 Matsumura, Soichi
	NRID 1000040710116 1000040710116 researchmap permalink 987654321 987654321 ORCID 0000-0001-5339-4312 0000-0001-5339-4312 著者名 Kakuta, Yoichi
	著者名 Maegawa-Higa, Yoko
	NRID 1000000964397 1000000964397 著者名 Fukae, Shota
	著者名 Tanaka, Ryo
	NRID 1000080759530 1000080759530 ORCID 0000-0001-5857-3483 0000-0001-5857-3483 researchmap permalink snakazawa snakazawa Scopus Author ID 36350232600 36350232600 著者名 Nakazawa, Shigeaki
	NRID 1000010648017 1000010648017 researchmap permalink yamanaka.kazuaki yamanaka.kazuaki Scopus Author ID 16318062300 16318062300 著者名 Yamanaka, Kazuaki
	NRID 1000090273648 1000090273648 researchmap permalink read0185079 read0185079 著者名 Miyagawa, Shuji
	NRID 1000030263263 1000030263263 researchmap permalink read0185096 read0185096 Scopus Author ID 7005880662 7005880662 著者名 Nonomura, Norio
キーワード等	Allotransplantation
	Kidney transplantation
	Xenotransplantation
内容	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01506-x.
抄録	Kidney transplantation is the only curative option for patients with chronic renal failure, significantly improving their survival and quality of life. However, this treatment remains limited by the shortage of organ donors. The shortage of kidney donors remains a serious problem all over the world, and is particularly severe in Japan. While advancements in immunosuppressive therapies and histocompatibility testing have improved outcomes in allogeneic kidney transplantation, the rising number of dialysis patients has worsened the gap between the demand for and supply of suitable donor organs. In response to this pressing need, xenotransplantation has gained attention as a promising alternative solution. Recent progress driven by gene-editing technologies, including CRISPR-Cas9, has facilitated the development of genetically modified pigs suitable for potential human transplantation. This review provides an overview of the key differences in immune response and infection risks between xenogeneic and allogeneic kidney transplants. In addition, it comprehensively examines the challenges and potential of xenogeneic kidney transplantation from multiple perspectives, including differences in immunosuppressive therapies between allogeneic and xenogeneic transplantation. We also discuss the feasibility of xenogeneic kidney transplantation as a solution to the organ shortage in Japan and present directions for addressing challenges toward clinical application. We hope this review will provide valuable insights into the potential of xenogeneic kidney transplantation as a new treatment option for chronic renal failure and contribute to efforts to address the donor shortage problem in Japan.
出版者	Springer
収録物名	Journal of Artificial Organs
刊行年月	2025-05-02
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102247
PISSN	14347229
eISSN	16190904
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10047-025-01506-x
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Artificial Organs. 2025
DC.title	Differences between xenotransplantation and allogeneic kidney transplantation: the current situation and future challenges in Japan
DC.creator	Matsumura, Soichi
	Kakuta, Yoichi
	Maegawa-Higa, Yoko
	Fukae, Shota
	Tanaka, Ryo
	Nakazawa, Shigeaki
	Yamanaka, Kazuaki
	Miyagawa, Shuji
	Nonomura, Norio
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-02
DC.identifier	https://doi.org/10.1007/s10047-025-01506-x
DC.subject	Allotransplantation
	Kidney transplantation
	Xenotransplantation
DC.description	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01506-x.
DCTERMS.abstract	Kidney transplantation is the only curative option for patients with chronic renal failure, significantly improving their survival and quality of life. However, this treatment remains limited by the shortage of organ donors. The shortage of kidney donors remains a serious problem all over the world, and is particularly severe in Japan. While advancements in immunosuppressive therapies and histocompatibility testing have improved outcomes in allogeneic kidney transplantation, the rising number of dialysis patients has worsened the gap between the demand for and supply of suitable donor organs. In response to this pressing need, xenotransplantation has gained attention as a promising alternative solution. Recent progress driven by gene-editing technologies, including CRISPR-Cas9, has facilitated the development of genetically modified pigs suitable for potential human transplantation. This review provides an overview of the key differences in immune response and infection risks between xenogeneic and allogeneic kidney transplants. In addition, it comprehensively examines the challenges and potential of xenogeneic kidney transplantation from multiple perspectives, including differences in immunosuppressive therapies between allogeneic and xenogeneic transplantation. We also discuss the feasibility of xenogeneic kidney transplantation as a solution to the organ shortage in Japan and present directions for addressing challenges toward clinical application. We hope this review will provide valuable insights into the potential of xenogeneic kidney transplantation as a new treatment option for chronic renal failure and contribute to efforts to address the donor shortage problem in Japan.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102247
citation_title	Differences between xenotransplantation and allogeneic kidney transplantation: the current situation and future challenges in Japan
citation_author	Matsumura, Soichi
	Kakuta, Yoichi
	Maegawa-Higa, Yoko
	Fukae, Shota
	Tanaka, Ryo
	Nakazawa, Shigeaki
	Yamanaka, Kazuaki
	Miyagawa, Shuji
	Nonomura, Norio
citation_publisher	Springer
citation_language	英語
citation_date	2025-05-02
citation_journal_title	Journal of Artificial Organs
citation_doi	https://doi.org/10.1007/s10047-025-01506-x
citation_public_url	https://hdl.handle.net/11094/102247

Differences between xenotransplantation and allogeneic kidney transplantation: the current situation and future challenges in Japan

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