学術雑誌論文

学術雑誌論文

text

Lasers in Medical Science. 2025, 40, p. 251

Spatial distribution of light-melanosome interaction dependent on irradiation fluence and spot size for short-pulsed laser skin treatment: A phantom study

Springer Science and Business Media Deutschland GmbH

英語

text

2025-05-30

https://doi.org/10.1007/s10103-025-04430-x

The version of record of this article, first published in Lasers in Medical Science, is available online at Publisher’s website: https://doi.org/10.1007/s10103-025-04430-x.

Short-pulsed lasers provide safe and efficacious treatment of pigmented lesions by setting irradiation parameters based on immediate whitening resulting from vacuolization. However, visual observation of this phenomenon as an irradiation endpoint is subjective and makes it difficult to assess the depth to which the light response is induced inside the skin. To quantitatively understand the dependence of the light response on irradiation parameters, this study analyzes the spatial distribution of light-melanosome interaction based on the fluence distribution in an optical phantom. Nanosecond laser irradiation was applied to an optical phantom with a uniform distribution of melanosomes with varying irradiation fluence and spot size. The observed spatial distribution of the light-melanosome response was compared with the fluence distribution in the phantom calculated from numerical simulations. The resulting relationship between irradiation parameters and optical response showed that cavitation increased rapidly at an in-phantom fluence of 1.37 J/cm² and reached a saturated state at the threshold fluence for melanosome disruption. Additionally, increasing the spot size promoted cavitation at greater depths as well as increasing irradiation fluence, highlighting the need to consider both irradiation fluence and spot size for treatment depth control. The experimental results suggest the potential for quantitative control of optical responses in laser treatment of pigmented lesions. Further validation by experiments on samples with spatial distribution of cutaneous melanosomes is required.

This article is licensed under a Creative Commons Attribution 4.0 International License.

102250

Spatial distribution of light-melanosome interaction dependent on irradiation fluence and spot size for short-pulsed laser skin treatment: A phantom study

Springer Science and Business Media Deutschland GmbH

英語

2025-05-30

Lasers in Medical Science

40

251

https://doi.org/10.1007/s10103-025-04430-x

https://hdl.handle.net/11094/102250