Subject-specific variability in cerebrospinal fluid flow characteristics through cerebral aqueducts in a healthy population: a magnetic resonance imaging and computational investigation

Maeda, Shusaku; Otani, Tomohiro; Yamada, Shigeki; Watanabe, Yoshiyuki; Wada, Shigeo

doi:https://doi.org/10.1007/s11517-025-03394-y

Subject-specific variability in cerebrospinal fluid flow characteristics through cerebral aqueducts in a healthy population: a magnetic resonance imaging and computational investigation

Maeda, Shusaku; Otani, Tomohiro; Yamada, Shigeki et al.

Medical and Biological Engineering and Computing, 2025

アクセス数:13件（2025-09-15 02:44 集計）

固定URL: https://hdl.handle.net/11094/102586

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タイトル	Subject-specific variability in cerebrospinal fluid flow characteristics through cerebral aqueducts in a healthy population: a magnetic resonance imaging and computational investigation
著者	著者名 Maeda, Shusaku
	NRID 1000040778990 1000040778990 ORCID 0000-0002-6431-2703 0000-0002-6431-2703 researchmap permalink bigvalley bigvalley Scopus Author ID 55625962900 55625962900 著者名 Otani, Tomohiro
	NRID 1000040422969 1000040422969 著者名 Yamada, Shigeki
	NRID 1000020362733 1000020362733 著者名 Watanabe, Yoshiyuki
	NRID 1000070240546 1000070240546 researchmap permalink shigeo41010 shigeo41010 Scopus Author ID 7401983636 7401983636 著者名 Wada, Shigeo
キーワード等	Cerebrospinal fluid
	Computational fluid dynamics
	Idiopathic normal pressure hydrocephalus
	Magnetic resonance imaging
	Stroke volume
内容	The version of record of this article, first published in Medical and Biological Engineering and Computing, is available online at Publisher’s website: https://doi.org/10.1007/s11517-025-03394-y.
抄録	Ventricular cerebrospinal fluid (CSF) flow has bi-directional flow profiles synchronized with cardiac pulsation. The increase in CSF stroke volume through the aqueduct (flow pathway between the third and fourth ventricle) is believed to be a biomarker of idiopathic normal pressure hydrocephalus (iNPH). However, several studies have reported that CSF stroke volume varies considerably even in healthy populations. To explore these variations from a fluid mechanics perspective, this study analyzed CSF flow characteristics in healthy individuals using magnetic resonance imaging (MRI)-based computational simulations. MRI data from 47 healthy subjects were acquired, and the maximum Reynolds number of the CSF flow through the aqueduct and the degree of CSF mixing were evaluated. Results showed that the Reynolds number of the CSF flow through the aqueduct was 28.6 ± 13.3, and the limited variation suggested fluid mechanical similarities of CSF flow characteristics in the healthy population. A positive correlation between CSF flow mixing and the Reynolds number was observed in both healthy populations and iNPH patients. These findings demonstrate that CSF flow through the aqueduct, especially in healthy populations, can be well characterized by examining fluid mechanical similarities.
出版者	Springer Science and Business Media Deutschland GmbH
収録物名	Medical and Biological Engineering and Computing
刊行年月	2025-06-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102586
PISSN	01400118
eISSN	17410444
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s11517-025-03394-y
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Medical and Biological Engineering and Computing. 2025
DC.title	Subject-specific variability in cerebrospinal fluid flow characteristics through cerebral aqueducts in a healthy population: a magnetic resonance imaging and computational investigation
DC.creator	Maeda, Shusaku
	Otani, Tomohiro
	Yamada, Shigeki
	Watanabe, Yoshiyuki
	Wada, Shigeo
DC.publisher	Springer Science and Business Media Deutschland GmbH
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-06-12
DC.identifier	https://doi.org/10.1007/s11517-025-03394-y
DC.subject	Cerebrospinal fluid
	Computational fluid dynamics
	Idiopathic normal pressure hydrocephalus
	Magnetic resonance imaging
	Stroke volume
DC.description	The version of record of this article, first published in Medical and Biological Engineering and Computing, is available online at Publisher’s website: https://doi.org/10.1007/s11517-025-03394-y.
DCTERMS.abstract	Ventricular cerebrospinal fluid (CSF) flow has bi-directional flow profiles synchronized with cardiac pulsation. The increase in CSF stroke volume through the aqueduct (flow pathway between the third and fourth ventricle) is believed to be a biomarker of idiopathic normal pressure hydrocephalus (iNPH). However, several studies have reported that CSF stroke volume varies considerably even in healthy populations. To explore these variations from a fluid mechanics perspective, this study analyzed CSF flow characteristics in healthy individuals using magnetic resonance imaging (MRI)-based computational simulations. MRI data from 47 healthy subjects were acquired, and the maximum Reynolds number of the CSF flow through the aqueduct and the degree of CSF mixing were evaluated. Results showed that the Reynolds number of the CSF flow through the aqueduct was 28.6 ± 13.3, and the limited variation suggested fluid mechanical similarities of CSF flow characteristics in the healthy population. A positive correlation between CSF flow mixing and the Reynolds number was observed in both healthy populations and iNPH patients. These findings demonstrate that CSF flow through the aqueduct, especially in healthy populations, can be well characterized by examining fluid mechanical similarities.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102586
citation_title	Subject-specific variability in cerebrospinal fluid flow characteristics through cerebral aqueducts in a healthy population: a magnetic resonance imaging and computational investigation
citation_author	Maeda, Shusaku
	Otani, Tomohiro
	Yamada, Shigeki
	Watanabe, Yoshiyuki
	Wada, Shigeo
citation_publisher	Springer Science and Business Media Deutschland GmbH
citation_language	英語
citation_date	2025-06-12
citation_journal_title	Medical and Biological Engineering and Computing
citation_doi	https://doi.org/10.1007/s11517-025-03394-y
citation_public_url	https://hdl.handle.net/11094/102586

Subject-specific variability in cerebrospinal fluid flow characteristics through cerebral aqueducts in a healthy population: a magnetic resonance imaging and computational investigation

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