In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects

Nishimura, Takahiro; Watanabe, Yusuke; Shimojo, Yu; Ozawa, Toshiyuki; Tsuruta, Daisuke

doi:https://doi.org/10.1007/s10103-025-04514-8

In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects

Nishimura, Takahiro; Watanabe, Yusuke; Shimojo, Yu et al.

Lasers in Medical Science, 2025, 40(1), 273

アクセス数:8件（2025-09-24 06:04 集計）

固定URL: https://hdl.handle.net/11094/102588

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タイトル	In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects
著者	NRID 1000010722829 1000010722829 researchmap permalink t_nishim t_nishim Scopus Author ID 36616463600 36616463600 著者名 Nishimura, Takahiro
	著者名 Watanabe, Yusuke
	NRID 1000030980734 1000030980734 ORCID 0000-0003-2102-1735 0000-0003-2102-1735 researchmap permalink yu_shimojo yu_shimojo 著者名 Shimojo, Yu
	NRID 1000050570602 1000050570602 著者名 Ozawa, Toshiyuki
	NRID 1000090382043 1000090382043 著者名 Tsuruta, Daisuke
キーワード等	Blue laser
	Coagulation
	In silico evaluation
	Tissue vaporization
内容	The version of record of this article, first published in Lasers in Medical Science, is available online at Publisher’s website: https://doi.org/10.1007/s10103-025-04514-8.
抄録	Blue diode laser irradiation has significant potential for realization of high vaporization efficiency with minimal thermal damage because of the strong blue light absorption of hemoglobin and the resulting shallow tissue penetration. This study presents an in silico framework for designing laser parameters, specifically pulse duration and power, for efficient vaporization under low-power irradiation conditions while minimizing thermal tissue damage. Computational simulations of laser-tissue interactions using the Monte Carlo light transport with dynamic optical properties model were conducted to evaluate vaporization and coagulation performance under various irradiation conditions. In addition to vaporization volume, the fraction of coagulated tissue was also calculated as a measure of thermal tissue damage. The in silico designs were validated experimentally through irradiation experiments performed on porcine liver tissue. Computational simulations revealed a non-monotonic relationship between pulse duration and vaporization volume at constant energy, as well as distinct trends for vaporization and coagulation. The experimental results confirmed the effectiveness of the simulation-derived parameters, and supported the practical utility of the proposed in silico design approach. The proposed in silico design approach enables quantitative analysis of vaporization and coagulation responses and can guide the development of safe and effective laser treatment protocols.
出版者	Springer Science and Business Media Deutschland GmbH
収録物名	Lasers in Medical Science
巻(号)	40(1)
ページ	273
刊行年月	2025-06-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102588
PISSN	02688921
eISSN	1435604X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10103-025-04514-8
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Lasers in Medical Science. 2025, 40(1), p. 273
DC.title	In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects
DC.creator	Nishimura, Takahiro
	Watanabe, Yusuke
	Shimojo, Yu
	Ozawa, Toshiyuki
	Tsuruta, Daisuke
DC.publisher	Springer Science and Business Media Deutschland GmbH
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-06-12
DC.identifier	https://doi.org/10.1007/s10103-025-04514-8
DC.subject	Blue laser
	Coagulation
	In silico evaluation
	Tissue vaporization
DC.description	The version of record of this article, first published in Lasers in Medical Science, is available online at Publisher’s website: https://doi.org/10.1007/s10103-025-04514-8.
DCTERMS.abstract	Blue diode laser irradiation has significant potential for realization of high vaporization efficiency with minimal thermal damage because of the strong blue light absorption of hemoglobin and the resulting shallow tissue penetration. This study presents an in silico framework for designing laser parameters, specifically pulse duration and power, for efficient vaporization under low-power irradiation conditions while minimizing thermal tissue damage. Computational simulations of laser-tissue interactions using the Monte Carlo light transport with dynamic optical properties model were conducted to evaluate vaporization and coagulation performance under various irradiation conditions. In addition to vaporization volume, the fraction of coagulated tissue was also calculated as a measure of thermal tissue damage. The in silico designs were validated experimentally through irradiation experiments performed on porcine liver tissue. Computational simulations revealed a non-monotonic relationship between pulse duration and vaporization volume at constant energy, as well as distinct trends for vaporization and coagulation. The experimental results confirmed the effectiveness of the simulation-derived parameters, and supported the practical utility of the proposed in silico design approach. The proposed in silico design approach enables quantitative analysis of vaporization and coagulation responses and can guide the development of safe and effective laser treatment protocols.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102588
citation_title	In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects
citation_author	Nishimura, Takahiro
	Watanabe, Yusuke
	Shimojo, Yu
	Ozawa, Toshiyuki
	Tsuruta, Daisuke
citation_publisher	Springer Science and Business Media Deutschland GmbH
citation_language	英語
citation_date	2025-06-12
citation_journal_title	Lasers in Medical Science
citation_volume	40
citation_issue	1
citation_firstpage	273
citation_doi	https://doi.org/10.1007/s10103-025-04514-8
citation_public_url	https://hdl.handle.net/11094/102588

In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects

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