Self-healing Poly(γ-glutamic acid)/hyaluronic acid hydrogels with in situ Hydroxyapatite formation

Kugimiya, Rina; Hsu, Yu I.; Uyama, Hiroshi

Polymer Degradation and Stability, 2025, 241, 111514

アクセス数:41件（2025-10-18 09:22 集計）

固定URL: https://hdl.handle.net/11094/102627

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タイトル
Self-healing Poly(γ-glutamic acid)/hyaluronic acid hydrogels with in situ Hydroxyapatite formation
著者
著者名
Kugimiya, Rina
NRID
1000010757678 1000010757678
ORCID
0000-0002-4533-7200 0000-0002-4533-7200
researchmap permalink
yuihsu yuihsu
Scopus Author ID
55389981500 55389981500
著者名
Hsu, Yu I.
NRID
1000070203594 1000070203594
ORCID
0000-0002-8587-2507 0000-0002-8587-2507
researchmap permalink
read0168389 read0168389
Scopus Author ID
7102108908 7102108908
著者名
Uyama, Hiroshi
キーワード等
Bioadhesion
Hydrogels
Poly(γ-glutamic acid)
SCHIFF-base reaction
Self-healing
内容
Kugimiya R., Hsu Y.I., Uyama H.. Self-healing Poly(γ-glutamic acid)/hyaluronic acid hydrogels with in situ Hydroxyapatite formation. Polymer Degradation and Stability 241, 111514 (2025); https://doi.org/10.1016/j.polymdegradstab.2025.111514.
抄録
Biocompatible hydrogels have potential applications as scaffold materials for repairing bone defects. However, they lack strength suitable for bone tissue and are easily damaged. Therefore, the development of hydrogels with high mechanical strength and self-healing properties is strongly desired. Poly(γ-glutamic acid) (PGA), a polysaccharide derived from natto, and hyaluronic acid (HA), a major component of the extracellular matrix (ECM), are both biocompatible and biodegradable, and thus expected to be used as potential biopolymers. In this study, self-healing hydrogels using PGA modified with adipic acid dihydrazide (PADH) and oxidized HA (OHA) with in situ hydroxyapatite (HAp) formation were developed via the Schiff base reaction. The hydrogel was easily obtained at room temperature by blending the two polymer precursor solutions and was injectable using a syringe with a short gelation time. The resulting hydrogels showed a significant increase in the mechanical strength as the amount of HAp in the hydrogels increased. The hydrogels demonstrated self-healing properties through reversible acylhydrazone bonds, although the self-healing efficiency was reduced in hydrogels with a high HAp content. Moreover, the hydrogels exhibited a low swelling ratio, 3D porous structures, and adhesion to chicken bone, suggesting that they are suitable for treating bone defects. In summary, our results indicate the potential of PGA/HA/HAp hydrogels given their injectability, superior mechanical strength relative to typical hydrogels, self-healing properties, and adhesion to bone.
出版者
Elsevier Ltd
収録物名
Polymer Degradation and Stability
巻(号)
241
ページ
111514
刊行年月
2025-07-08
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102627
PISSN
01413910
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1016/j.polymdegradstab.2025.111514
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article