Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate

Tanaka, Ryo; Kakuta, Yoichi; Nonomura, Norio et al.

Chemistry and Biodiversity, 2025, e00579

アクセス数:231件（2026-02-15 23:05 集計）

固定URL: https://hdl.handle.net/11094/102631

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タイトル
Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate
著者
NRID
1000060909654 1000060909654
ORCID
0000-0003-1144-7820 0000-0003-1144-7820
researchmap permalink
ryotnk0302 ryotnk0302
Scopus Author ID
57203308901 57203308901
著者名
Tanaka, Ryo
NRID
1000040710116 1000040710116
ORCID
0000-0001-5339-4312 0000-0001-5339-4312
researchmap permalink
987654321 987654321
Scopus Author ID
23009020800 23009020800
著者名
Kakuta, Yoichi
NRID
1000030263263 1000030263263
researchmap permalink
read0185096 read0185096
Scopus Author ID
7005880662 7005880662
著者名
Nonomura, Norio
NRID
1000000631300 1000000631300
ORCID
0000-0001-8186-094X 0000-0001-8186-094X
researchmap permalink
KimuraUNM KimuraUNM
Scopus Author ID
57199363473 57199363473
著者名
Kimura, Tomonori
キーワード等
biomarker
chronic kidney disease
d-amino acids
glomerular filtration rate
内容
Tanaka R., Kakuta Y., Nonomura N., et al. Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate. Chemistry and Biodiversity (2025); https://doi.org/10.1002/cbdv.202500579.
抄録
Chronic kidney disease (CKD) is a major global health issue, requiring accurate and noninvasive renal function assessment. Glomerular filtration rate (GFR) is the standard measure, but current methods, including inulin clearance and creatinine-based estimation, have limitations in accuracy, invasiveness, and practicality. We investigated d-serine and d-asparagine as novel endogenous biomarkers for GFR evaluation. Their clearance strongly correlates with inulin clearance, demonstrating high reliability and reduced muscle mass dependency compared to creatinine-based methods. Our findings suggest that d-amino acids offer a promising, less invasive alternative for precise renal function assessment, aiding early CKD detection and management. In addition, d-amino acids have recently been reported to be useful as biomarkers not only in the renal field but also in various other fields such as malignancy and infectious diseases. This article highlights the potential of d-amino acids in enhancing CKD diagnosis and management.
出版者
John Wiley and Sons Inc
収録物名
Chemistry and Biodiversity
ページ
e00579
刊行年月
2025-06-29
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102631
PISSN
16121872
eISSN
16121880
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/cbdv.202500579
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article