Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages

Sakai, Hirohiko; Sasaki, Jun-Ichi; Kitagawa, Haruaki et al.

Macromolecular Bioscience, 2025

アクセス数:23件（2025-09-16 13:51 集計）

固定URL: https://hdl.handle.net/11094/102635

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論文情報

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タイトル
Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages
著者
ORCID
0009-0009-7404-0922 0009-0009-7404-0922
著者名
Sakai, Hirohiko
NRID
1000050530490 1000050530490
ORCID
0000-0002-0330-0397 0000-0002-0330-0397
researchmap permalink
Sasaki_JI Sasaki_JI
Scopus Author ID
36138008500 36138008500
著者名
Sasaki, Jun-Ichi
NRID
1000050736246 1000050736246
ORCID
0000-0002-5270-4865 0000-0002-5270-4865
researchmap permalink
kitagawa_h kitagawa_h
Scopus Author ID
55267186700 55267186700
著者名
Kitagawa, Haruaki
NRID
1000030964952 1000030964952
ORCID
0000-0001-8843-1697 0000-0001-8843-1697
researchmap permalink
gabriela_abe gabriela_abe
著者名
Abe, Gabriela L.
NRID
1000010839202 1000010839202
ORCID
0000-0002-7690-2567 0000-0002-7690-2567
researchmap permalink
tomoki-kohno tomoki-kohno
Scopus Author ID
57214627603 57214627603
著者名
Kohno, Tomoki
NRID
1000001005661 1000001005661
ORCID
0009-0005-4064-0779 0009-0005-4064-0779
researchmap permalink
funayama_naoya funayama_naoya
著者名
Funayama, Naoya
NRID
1000080243244 1000080243244
ORCID
0000-0003-3655-4809 0000-0003-3655-4809
researchmap permalink
read0014210 read0014210
Scopus Author ID
55994423600 55994423600
著者名
Imazato, Satoshi
キーワード等
anti-inflammation
bone regeneration
pathological stage tracking
smart bioactive materials
stepwise ion release
内容
Sakai H., Sasaki J.I., Kitagawa H., et al. Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages. Macromolecular Bioscience, (2025); https://doi.org/10.1002/mabi.202500268.
抄録
Bioactive glasses (BGs) are highly biocompatible with affinity for hard tissues and exhibit high bioactivity through ion release. Smart BGs that allow controlled ion release are required because uncontrolled release can lead to unexpected adverse effects on tissue regeneration. Strontium promotes osteoblast differentiation of mesenchymal stem cells (MSCs) and inhibits osteoclast activity. In this study, the release profile of strontium is regulated by the incorporation of aluminum into a phosphate-based BG. Furthermore, composites of strontium-releasing BG and lithium-releasing BG (Li/Sr-BG) show stepwise ion release, with rapid lithium release followed by sustained strontium release. Li/Sr-BG increases the expression of osteogenic markers and mineral deposition in MSCs, but suppresses osteoclast maturation, including multinucleation and osteoclast marker expression. Additionally, application of Li/Sr-BG to inflammatory macrophages decreases phagocytic activity and inflammatory gene expression, while increasing the expression of anti-inflammatory markers. Analysis of signaling proteins reveals that osteogenic and anti-inflammatory effects of Li/Sr-BG are attributed to the release of strontium and lithium, respectively. This study demonstrates that Li/Sr-BGs can be used for the development of novel smart bioactive materials that effectively suppress inflammation and promote bone formation in a manner that follows the process of bone regeneration.
出版者
John Wiley and Sons Inc
収録物名
Macromolecular Bioscience
刊行年月
2025-06-29
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102635
PISSN
16165187
eISSN
16165195
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/mabi.202500268
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article