Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction

Kida, Hirota; Matsuoka, Yuki; Sakamoto, Daisuke; Hikoso, Shungo; Nakatani, Daisaku; Okada, Katsuki; Sunaga, Akihiro; Sato, Taiki; Kitamura, Tetsuhisa; Sakata, Yasuhiko; Sato, Hiroshi; Hori, Masatsugu; Komuro, Issei; Sotomi, Yohei; Sakata, Yasushi

doi:https://doi.org/10.1161/JAHA.125.043005

Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction

Kida, Hirota; Matsuoka, Yuki; Sakamoto, Daisuke et al.

Journal of the American Heart Association, 2025, 14(14), e043005

アクセス数:95件（2025-09-29 11:34 集計）

固定URL: https://hdl.handle.net/11094/102637

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タイトル	Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction
著者	著者名 Kida, Hirota
	著者名 Matsuoka, Yuki
	著者名 Sakamoto, Daisuke
	NRID 1000030423164 1000030423164 ORCID 0000-0003-2284-1970 0000-0003-2284-1970 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 57578643800 57578643800 著者名 Hikoso, Shungo
	NRID 1000060444535 1000060444535 ORCID 0000-0002-1534-2033 0000-0002-1534-2033 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 著者名 Nakatani, Daisaku
	NRID 1000020776489 1000020776489 ORCID 0000-0002-1725-781X 0000-0002-1725-781X researchmap permalink katsuki_okada katsuki_okada Scopus Author ID 13613369100 13613369100 著者名 Okada, Katsuki
	NRID 1000010812258 1000010812258 ORCID 0000-0003-2590-6696 0000-0003-2590-6696 researchmap permalink 10812258 10812258 Scopus Author ID 56647970400 56647970400 著者名 Sunaga, Akihiro
	著者名 Sato, Taiki
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	NRID 1000090379206 1000090379206 ORCID 0000-0001-6809-8487 0000-0001-6809-8487 researchmap permalink yasuhiko.sakata.2020 yasuhiko.sakata.2020 Scopus Author ID 7201629964 7201629964 著者名 Sakata, Yasuhiko
	著者名 Sato, Hiroshi
	NRID 1000020124779 1000020124779 著者名 Hori, Masatsugu
	著者名 Komuro, Issei
	著者名 Sotomi, Yohei
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 著者名 Sakata, Yasushi
キーワード等	acute myocardial infarction
	chronic kidney disease
	hemodialysis
	primary percutaneous coronary intervention
	real‐world data
内容	Kida H., Matsuoka Y., Sakamoto D., et al. Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction. Journal of the American Heart Association 14, e043005 (2025); https://doi.org/10.1161/JAHA.125.043005.
抄録	BACKGROUND: Primary percutaneous coronary intervention is the preferred treatment for acute myocardial infarction. However, in patients with chronic kidney disease (CKD), the use of contrast media can exacerbate renal dysfunction, often necessitating alternative strategies. The impact of CKD on acute myocardial infarction prognosis, particularly in the context of percutaneous coronary intervention, is not fully understood. METHODS AND RESULTS: This study utilized real-world registry data from the OACIS (Osaka Acute Coronary Insufficiency Study) to evaluate prognosis across different CKD grades, including advanced CKD and hemodialysis. From a database of 12 093 patients with acute myocardial infarction, we identified 8411 patients with renal function data at admission (a median follow-up period of 1765 days). These patients were classified into 8 CKD categories based on estimated glomerular filtration rate (eGFR); G1 (eGFR≥90 mL/min per 1.73 m²): n=1122, G2 (90>eGFR ≥60 mL/min per 1.73 m²): n=3588, G3a (60>eGFR≥45 mL/min per 1.73 m²): n=1923, G3b (45>eGFR≥30 mL/min per 1.73 m²): n=1030, G4: (30>eGFR≥15 mL/min per 1.73 m²): n=473, G5a: (15>eGFR≥8 mL/min per 1.73 m²): n=80, G5b: (eGFR<8 mL/min per 1.73 m²): n=53 and hemodialysis: n=142. Percutaneous coronary intervention rates declined with advancing CKD, reaching the lowest in G5a (80.3%) but increasing again in G5b and hemodialysis groups (≈90%). Thirty-day all-cause mortality rates increased with CKD severity, with a notable reduction in G5b (9.4%) before rising again in patients with hemodialysis (16.9%). Long-term data showed a progressive worsening of prognosis with advanced CKD, culminating in the poorest outcomes among patients with hemodialysis. CONCLUSIONS: This study demonstrated differential impacts of CKD severity on short- and long-term clinical outcomes in the context of patients with acute myocardial infarction.
出版者	American Heart Association, Inc.
収録物名	Journal of the American Heart Association
巻(号)	14(14)
ページ	e043005
刊行年月	2025-07-15
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102637
eISSN	20479980
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1161/JAHA.125.043005
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of the American Heart Association. 2025, 14(14), p. e043005
DC.title	Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction
DC.creator	Kida, Hirota
	Matsuoka, Yuki
	Sakamoto, Daisuke
	Hikoso, Shungo
	Nakatani, Daisaku
	Okada, Katsuki
	Sunaga, Akihiro
	Sato, Taiki
	Kitamura, Tetsuhisa
	Sakata, Yasuhiko
	Sato, Hiroshi
	Hori, Masatsugu
	Komuro, Issei
	Sotomi, Yohei
	Sakata, Yasushi
DC.publisher	American Heart Association, Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-15
DC.identifier	https://doi.org/10.1161/JAHA.125.043005
DC.subject	acute myocardial infarction
	chronic kidney disease
	hemodialysis
	primary percutaneous coronary intervention
	real‐world data
DC.description	Kida H., Matsuoka Y., Sakamoto D., et al. Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction. Journal of the American Heart Association 14, e043005 (2025); https://doi.org/10.1161/JAHA.125.043005.
DCTERMS.abstract	BACKGROUND: Primary percutaneous coronary intervention is the preferred treatment for acute myocardial infarction. However, in patients with chronic kidney disease (CKD), the use of contrast media can exacerbate renal dysfunction, often necessitating alternative strategies. The impact of CKD on acute myocardial infarction prognosis, particularly in the context of percutaneous coronary intervention, is not fully understood. METHODS AND RESULTS: This study utilized real-world registry data from the OACIS (Osaka Acute Coronary Insufficiency Study) to evaluate prognosis across different CKD grades, including advanced CKD and hemodialysis. From a database of 12 093 patients with acute myocardial infarction, we identified 8411 patients with renal function data at admission (a median follow-up period of 1765 days). These patients were classified into 8 CKD categories based on estimated glomerular filtration rate (eGFR); G1 (eGFR≥90 mL/min per 1.73 m²): n=1122, G2 (90>eGFR ≥60 mL/min per 1.73 m²): n=3588, G3a (60>eGFR≥45 mL/min per 1.73 m²): n=1923, G3b (45>eGFR≥30 mL/min per 1.73 m²): n=1030, G4: (30>eGFR≥15 mL/min per 1.73 m²): n=473, G5a: (15>eGFR≥8 mL/min per 1.73 m²): n=80, G5b: (eGFR<8 mL/min per 1.73 m²): n=53 and hemodialysis: n=142. Percutaneous coronary intervention rates declined with advancing CKD, reaching the lowest in G5a (80.3%) but increasing again in G5b and hemodialysis groups (≈90%). Thirty-day all-cause mortality rates increased with CKD severity, with a notable reduction in G5b (9.4%) before rising again in patients with hemodialysis (16.9%). Long-term data showed a progressive worsening of prognosis with advanced CKD, culminating in the poorest outcomes among patients with hemodialysis. CONCLUSIONS: This study demonstrated differential impacts of CKD severity on short- and long-term clinical outcomes in the context of patients with acute myocardial infarction.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102637
citation_title	Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction
citation_author	Kida, Hirota
	Matsuoka, Yuki
	Sakamoto, Daisuke
	Hikoso, Shungo
	Nakatani, Daisaku
	Okada, Katsuki
	Sunaga, Akihiro
	Sato, Taiki
	Kitamura, Tetsuhisa
	Sakata, Yasuhiko
	Sato, Hiroshi
	Hori, Masatsugu
	Komuro, Issei
	Sotomi, Yohei
	Sakata, Yasushi
citation_publisher	American Heart Association, Inc.
citation_language	英語
citation_date	2025-07-15
citation_journal_title	Journal of the American Heart Association
citation_volume	14
citation_issue	14
citation_firstpage	e043005
citation_doi	https://doi.org/10.1161/JAHA.125.043005
citation_public_url	https://hdl.handle.net/11094/102637

Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction

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