Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment

Nakano, Eriko; Mukai, Kosuke; Yamamoto, Koichi; Otsuki, Michio; Fukuhara, Atsunori; Shimomura, Iichiro

doi:https://doi.org/10.1111/jch.70097

Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment

Nakano, Eriko; Mukai, Kosuke; Yamamoto, Koichi et al.

Journal of Clinical Hypertension, 2025, 27(7), e70097

アクセス数:11件（2025-09-04 12:23 集計）

固定URL: https://hdl.handle.net/11094/102640

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タイトル	Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment
著者	著者名 Nakano, Eriko
	NRID 1000020815352 1000020815352 ORCID 0000-0002-9365-5561 0000-0002-9365-5561 researchmap permalink mukai mukai Scopus Author ID 55045414800 55045414800 著者名 Mukai, Kosuke
	NRID 1000000528424 1000000528424 ORCID 0000-0003-0107-9315 0000-0003-0107-9315 researchmap permalink kymt0410 kymt0410 Scopus Author ID 55624482466 55624482466 著者名 Yamamoto, Koichi
	NRID 1000000403056 1000000403056 著者名 Otsuki, Michio
	NRID 1000000437328 1000000437328 ORCID 0000-0002-6289-3778 0000-0002-6289-3778 researchmap permalink AtsuF AtsuF Scopus Author ID 7003835710 7003835710 著者名 Fukuhara, Atsunori
	NRID 1000060346145 1000060346145 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 著者名 Shimomura, Iichiro
キーワード等	abdominal fat
	aldosterone-producing adenoma
	ectopic fat
	idiopathic hyperaldosteronism
	primary aldosteronism
内容	Nakano E., Mukai K., Yamamoto K., et al. Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment. Journal of Clinical Hypertension 27, e70097 (2025); https://doi.org/10.1111/jch.70097.
抄録	The abdominal and ectopic fats increase after primary aldosteronism (PA) treatment in aldosterone-producing adenoma (APA) but not idiopathic hyperaldosteronism (IHA) has been reported. Additionally, the relationship of these fats to plasma aldosterone concentration remains unclear. This retrospective study aimed to elucidate the influence of aldosterone on body composition. We compared the body composition parameters of APA and IHA patients at baseline and after PA treatment. APA patients tended to have a smaller subcutaneous fat area (SFA) than IHA patients at baseline. The SFA, visceral fat area (VFA) and dyslipidemia prevalence of APA patients but not IHA patients significantly increased after PA treatment. The SFA and the VFA change after adrenalectomy were positively correlated with the baseline plasma aldosterone concentration (PAC) in APA patients. At baseline, APA patients' intramuscular adipose tissue content (IMAC) was significantly less than that of IHA patients. The IMAC of PA patients at baseline was negatively correlated with PAC. The IMAC of APA patients but not IHA patients significantly increased after PA treatment. This study demonstrated that SFA, VFA and IMAC increased after PA treatment in APA patients but not in IHA patients, thereby suggesting a relationship between body composition and aldosterone.
出版者	John Wiley and Sons Inc
収録物名	Journal of Clinical Hypertension
巻(号)	27(7)
ページ	e70097
刊行年月	2025-07-20
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102640
PISSN	15246175
eISSN	17517176
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/jch.70097
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Clinical Hypertension. 2025, 27(7), p. e70097
DC.title	Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment
DC.creator	Nakano, Eriko
	Mukai, Kosuke
	Yamamoto, Koichi
	Otsuki, Michio
	Fukuhara, Atsunori
	Shimomura, Iichiro
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-20
DC.identifier	https://doi.org/10.1111/jch.70097
DC.subject	abdominal fat
	aldosterone-producing adenoma
	ectopic fat
	idiopathic hyperaldosteronism
	primary aldosteronism
DC.description	Nakano E., Mukai K., Yamamoto K., et al. Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment. Journal of Clinical Hypertension 27, e70097 (2025); https://doi.org/10.1111/jch.70097.
DCTERMS.abstract	The abdominal and ectopic fats increase after primary aldosteronism (PA) treatment in aldosterone-producing adenoma (APA) but not idiopathic hyperaldosteronism (IHA) has been reported. Additionally, the relationship of these fats to plasma aldosterone concentration remains unclear. This retrospective study aimed to elucidate the influence of aldosterone on body composition. We compared the body composition parameters of APA and IHA patients at baseline and after PA treatment. APA patients tended to have a smaller subcutaneous fat area (SFA) than IHA patients at baseline. The SFA, visceral fat area (VFA) and dyslipidemia prevalence of APA patients but not IHA patients significantly increased after PA treatment. The SFA and the VFA change after adrenalectomy were positively correlated with the baseline plasma aldosterone concentration (PAC) in APA patients. At baseline, APA patients' intramuscular adipose tissue content (IMAC) was significantly less than that of IHA patients. The IMAC of PA patients at baseline was negatively correlated with PAC. The IMAC of APA patients but not IHA patients significantly increased after PA treatment. This study demonstrated that SFA, VFA and IMAC increased after PA treatment in APA patients but not in IHA patients, thereby suggesting a relationship between body composition and aldosterone.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102640
citation_title	Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment
citation_author	Nakano, Eriko
	Mukai, Kosuke
	Yamamoto, Koichi
	Otsuki, Michio
	Fukuhara, Atsunori
	Shimomura, Iichiro
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2025-07-20
citation_journal_title	Journal of Clinical Hypertension
citation_volume	27
citation_issue	7
citation_firstpage	e70097
citation_doi	https://doi.org/10.1111/jch.70097
citation_public_url	https://hdl.handle.net/11094/102640

Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment

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