Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction

MORI, YOSAI; GOTO, SO; MAEDA, NAOYUKI; OHNUMA, KAZUHIKO; LAWU, TJUNDEWO; NODA, TORU; MIYATA, KAZUNORI

doi:https://doi.org/10.1016/j.ajo.2025.08.049

Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction

MORI, YOSAI; GOTO, SO; MAEDA, NAOYUKI et al.

American Journal of Ophthalmology, 2026, 281, 109-117

アクセス数:185件（2026-02-15 23:28 集計）

固定URL: https://hdl.handle.net/11094/102871

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タイトル	Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction
著者	著者名 MORI, YOSAI
	NRID 1000070972933 1000070972933 ORCID 0000-0003-4171-0781 0000-0003-4171-0781 researchmap permalink gotoso gotoso Scopus Author ID 55319462800 55319462800 著者名 GOTO, SO
	NRID 1000000273623 1000000273623 著者名 MAEDA, NAOYUKI
	著者名 OHNUMA, KAZUHIKO
	著者名 LAWU, TJUNDEWO
	著者名 NODA, TORU
	著者名 MIYATA, KAZUNORI
内容	MORI Y., GOTO S., MAEDA N., et al. Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction. American Journal of Ophthalmology 281, 109 (2026); https://doi.org/10.1016/j.ajo.2025.08.049.
抄録	Purpose: To evaluate the predictive accuracy of the O formula, based on the ray-tracing method, compared with the latest formulas available on the ESCRS website. Design: Retrospective consecutive case series at a single center. Methods: Records of consecutive patients who underwent routine cataract surgery implanted with acrylic IOLs between August 2021 and December 2022 were retrospectively reviewed. The prediction accuracy of the O formula was compared with that of the Barrett Universal II (BUII), Emmetropia Verifying Optical 2.0 (EVO), Kane, Pearl-DGS formulas based on the website of ESCRS, and the SRK/T formula. Swept-source optical coherence tomography (SS-OCT)-based biometry and anterior segment SS-OCT were performed preoperatively, and manifest refraction was assessed 1 month postoperatively. Primary outcomes were root-mean-square absolute error (RMSAE), median absolute error (MedAE), and the proportions within ±0.50 D and ±1.00 D. Results: A total of 325 eyes (258 patients) were included. The RMSAE of the O formula, BUII, EVO, Kane, Pearl-DGS, and SRK/T were 0.396, 0.468, 0.441, 0.449, 0.550, and 0.425, respectively. In GEE models, mean absolute error was significantly lower with the O formula than with BUII, EVO, Kane, and Pearl-DGS; no difference versus SRK/T was detected. The percentage of eyes within ±0.50 D was 78.7% for the O formula, 71.4% for BUII, 73.6% for EVO, 73.9% for Kane, 61.6% for Pearl-DGS, and 76.3% for SRK/T. The O formula achieved significantly higher percentages of eyes within both ±0.50 D and ±1.00 D of the predicted refraction compared to Pearl-DGS (P < .001). Conclusions: The O formula demonstrated high refractive accuracy without A-constant optimization and performs favorably against widely used formulas. It can be used as a fail-safe in IOL power calculation, as it is less susceptible to prediction errors exceeding 1.0 D.
出版者	Elsevier Inc.
収録物名	American Journal of Ophthalmology
巻(号)	281
ページ	109-117
刊行年月	2026-01-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102871
PISSN	00029394
eISSN	18791891
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.ajo.2025.08.049
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	American Journal of Ophthalmology. 2026, 281, p. 109-117
DC.title	Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction
DC.creator	MORI, YOSAI
	GOTO, SO
	MAEDA, NAOYUKI
	OHNUMA, KAZUHIKO
	LAWU, TJUNDEWO
	NODA, TORU
	MIYATA, KAZUNORI
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-01-01
DC.identifier	https://doi.org/10.1016/j.ajo.2025.08.049
DC.description	MORI Y., GOTO S., MAEDA N., et al. Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction. American Journal of Ophthalmology 281, 109 (2026); https://doi.org/10.1016/j.ajo.2025.08.049.
DCTERMS.abstract	Purpose: To evaluate the predictive accuracy of the O formula, based on the ray-tracing method, compared with the latest formulas available on the ESCRS website. Design: Retrospective consecutive case series at a single center. Methods: Records of consecutive patients who underwent routine cataract surgery implanted with acrylic IOLs between August 2021 and December 2022 were retrospectively reviewed. The prediction accuracy of the O formula was compared with that of the Barrett Universal II (BUII), Emmetropia Verifying Optical 2.0 (EVO), Kane, Pearl-DGS formulas based on the website of ESCRS, and the SRK/T formula. Swept-source optical coherence tomography (SS-OCT)-based biometry and anterior segment SS-OCT were performed preoperatively, and manifest refraction was assessed 1 month postoperatively. Primary outcomes were root-mean-square absolute error (RMSAE), median absolute error (MedAE), and the proportions within ±0.50 D and ±1.00 D. Results: A total of 325 eyes (258 patients) were included. The RMSAE of the O formula, BUII, EVO, Kane, Pearl-DGS, and SRK/T were 0.396, 0.468, 0.441, 0.449, 0.550, and 0.425, respectively. In GEE models, mean absolute error was significantly lower with the O formula than with BUII, EVO, Kane, and Pearl-DGS; no difference versus SRK/T was detected. The percentage of eyes within ±0.50 D was 78.7% for the O formula, 71.4% for BUII, 73.6% for EVO, 73.9% for Kane, 61.6% for Pearl-DGS, and 76.3% for SRK/T. The O formula achieved significantly higher percentages of eyes within both ±0.50 D and ±1.00 D of the predicted refraction compared to Pearl-DGS (P < .001). Conclusions: The O formula demonstrated high refractive accuracy without A-constant optimization and performs favorably against widely used formulas. It can be used as a fail-safe in IOL power calculation, as it is less susceptible to prediction errors exceeding 1.0 D.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	102871
citation_title	Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction
citation_author	MORI, YOSAI
	GOTO, SO
	MAEDA, NAOYUKI
	OHNUMA, KAZUHIKO
	LAWU, TJUNDEWO
	NODA, TORU
	MIYATA, KAZUNORI
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2026-01-01
citation_journal_title	American Journal of Ophthalmology
citation_volume	281
citation_firstpage	109
citation_lastpage	117
citation_doi	https://doi.org/10.1016/j.ajo.2025.08.049
citation_public_url	https://hdl.handle.net/11094/102871

Accuracy of the O Formula Based on OCT and Ray-Tracing for Intraocular Lens Power Prediction

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