Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas

Rafiq, Hasinah; Hsu, Yu I.; Uyama, Hiroshi

doi:https://doi.org/10.1016/j.surfin.2025.107514

Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas

Rafiq, Hasinah; Hsu, Yu I.; Uyama, Hiroshi

Surfaces and Interfaces, 2025, 73, 107514

アクセス数:30件（2025-11-29 03:24 集計）

固定URL: https://hdl.handle.net/11094/102872

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タイトル	Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas
著者	著者名 Rafiq, Hasinah
	NRID 1000010757678 1000010757678 ORCID 0000-0002-4533-7200 0000-0002-4533-7200 researchmap permalink yuihsu yuihsu Scopus Author ID 55389981500 55389981500 著者名 Hsu, Yu I.
	NRID 1000070203594 1000070203594 ORCID 0000-0002-8587-2507 0000-0002-8587-2507 researchmap permalink read0168389 read0168389 Scopus Author ID 7102108908 7102108908 著者名 Uyama, Hiroshi
キーワード等	Chlorine dioxide radical gas
	CO2 adsorption
	Hydroxyapatite deposition
	Nanoporous PLLA microspheres
	Surface oxidation
	TBO dye adsorption
内容	Rafiq H., Hsu Y.I., Uyama H.. Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas. Surfaces and Interfaces 73, 107514 (2025); https://doi.org/10.1016/j.surfin.2025.107514.
抄録	Nanoporous polymer microspheres fabricated from biodegradable and biocompatible polymers such as poly (L-lactic acid) (PLLA) are excellent candidates for bone tissue engineering due to their high surface area and porosity. However, nanoporous surfaces often exhibit high hydrophobicity, and the lack of functional groups on PLLA limits their ability to support the efficient biomineralization process required for bone tissue engineering. In this study, we report a mild and non-destructive surface oxidation method to functionalize the surface of nanoporous PLLA microspheres using light-activated chlorine dioxide (ClO₂•) radical gas. This gas-phase surface oxidation approach introduces polar functional groups onto the microsphere surface while preserving its nanoporous morphology. The oxidation process was optimized via X-ray photoelectron spectroscopy (XPS) and toluidine blue (TBO) dye adsorption studies. Scanning electron microscopy (SEM) and nitrogen adsorption-desorption isotherm measurements confirmed that the nanoporous structure remained largely intact post-oxidation. Importantly, the oxidized microspheres were successfully functionalized with carboxyl and hydroxyl groups and exhibited improved hydroxyapatite deposition upon immersion in modified simulated body fluid (mSBF). This work demonstrates a facile, non-destructive strategy for surface functionalization of nanoporous PLLA microspheres without sacrificing their nanoporous architecture, representing a crucial step towards developing nanoporous biomineralizable scaffolds for future bone tissue engineering applications.
出版者	Elsevier B.V.
収録物名	Surfaces and Interfaces
巻(号)	73
ページ	107514
刊行年月	2025-09-15
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102872
PISSN	24680230
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.surfin.2025.107514
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Surfaces and Interfaces. 2025, 73, p. 107514
DC.title	Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas
DC.creator	Rafiq, Hasinah
	Hsu, Yu I.
	Uyama, Hiroshi
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-09-15
DC.identifier	https://doi.org/10.1016/j.surfin.2025.107514
DC.subject	Chlorine dioxide radical gas
	CO2 adsorption
	Hydroxyapatite deposition
	Nanoporous PLLA microspheres
	Surface oxidation
	TBO dye adsorption
DC.description	Rafiq H., Hsu Y.I., Uyama H.. Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas. Surfaces and Interfaces 73, 107514 (2025); https://doi.org/10.1016/j.surfin.2025.107514.
DCTERMS.abstract	Nanoporous polymer microspheres fabricated from biodegradable and biocompatible polymers such as poly (L-lactic acid) (PLLA) are excellent candidates for bone tissue engineering due to their high surface area and porosity. However, nanoporous surfaces often exhibit high hydrophobicity, and the lack of functional groups on PLLA limits their ability to support the efficient biomineralization process required for bone tissue engineering. In this study, we report a mild and non-destructive surface oxidation method to functionalize the surface of nanoporous PLLA microspheres using light-activated chlorine dioxide (ClO₂•) radical gas. This gas-phase surface oxidation approach introduces polar functional groups onto the microsphere surface while preserving its nanoporous morphology. The oxidation process was optimized via X-ray photoelectron spectroscopy (XPS) and toluidine blue (TBO) dye adsorption studies. Scanning electron microscopy (SEM) and nitrogen adsorption-desorption isotherm measurements confirmed that the nanoporous structure remained largely intact post-oxidation. Importantly, the oxidized microspheres were successfully functionalized with carboxyl and hydroxyl groups and exhibited improved hydroxyapatite deposition upon immersion in modified simulated body fluid (mSBF). This work demonstrates a facile, non-destructive strategy for surface functionalization of nanoporous PLLA microspheres without sacrificing their nanoporous architecture, representing a crucial step towards developing nanoporous biomineralizable scaffolds for future bone tissue engineering applications.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102872
citation_title	Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas
citation_author	Rafiq, Hasinah
	Hsu, Yu I.
	Uyama, Hiroshi
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2025-09-15
citation_journal_title	Surfaces and Interfaces
citation_volume	73
citation_firstpage	107514
citation_doi	https://doi.org/10.1016/j.surfin.2025.107514
citation_public_url	https://hdl.handle.net/11094/102872

Functionalization of nanoporous poly (L-lactic acid) microspheres using light-activated chlorine dioxide radical gas

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