Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study

Terada, Hiroaki; Nakamura, Kenji; Fujita, Shoto; Gon, Yasufumi; Kawano, Tomohiro; Kitano, Takaya; Takasugi, Junji; Kanki, Hideaki; Zha, Ling; Komatsu, Masayo; Kitamura, Tetsuhisa; Sasaki, Tsutomu

doi:https://doi.org/10.1016/j.thromres.2025.109455

Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study

Terada, Hiroaki; Nakamura, Kenji; Fujita, Shoto et al.

Thrombosis Research, 2025, 254, 109455

アクセス数:8件（2025-11-04 19:26 集計）

固定URL: https://hdl.handle.net/11094/102878

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タイトル	Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study
著者	著者名 Terada, Hiroaki
	著者名 Nakamura, Kenji
	著者名 Fujita, Shoto
	NRID 1000070751311 1000070751311 ORCID 0000-0002-3907-1741 0000-0002-3907-1741 researchmap permalink y-gon y-gon Scopus Author ID 56565092900 56565092900 著者名 Gon, Yasufumi
	NRID 1000000983181 1000000983181 ORCID 0000-0002-6282-4991 0000-0002-6282-4991 researchmap permalink tomohirokawano tomohirokawano Scopus Author ID 57192176743 57192176743 著者名 Kawano, Tomohiro
	NRID 1000070772193 1000070772193 ORCID 0000-0003-1903-8255 0000-0003-1903-8255 researchmap permalink takayakitano takayakitano Scopus Author ID 57190440737 57190440737 著者名 Kitano, Takaya
	NRID 1000040796033 1000040796033 ORCID 0000-0002-6200-4571 0000-0002-6200-4571 researchmap permalink j-takasugi j-takasugi 著者名 Takasugi, Junji
	NRID 1000010774218 1000010774218 ORCID 0000-0001-8531-7645 0000-0001-8531-7645 researchmap permalink kan1 kan1 Scopus Author ID 58437295000 58437295000 著者名 Kanki, Hideaki
	NRID 1000040895398 1000040895398 ORCID 0000-0003-4668-4199 0000-0003-4668-4199 researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 著者名 Zha, Ling
	NRID 1000080726315 1000080726315 ORCID 0000-0003-4861-4717 0000-0003-4861-4717 researchmap permalink k_masayo k_masayo Scopus Author ID 56257724000 56257724000 著者名 Komatsu, Masayo
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	NRID 1000020534879 1000020534879 ORCID 0000-0001-8726-978X 0000-0001-8726-978X researchmap permalink tsutomusasaki1111 tsutomusasaki1111 Scopus Author ID 7407394272 7407394272 著者名 Sasaki, Tsutomu
キーワード等	Cancer
	Ischemic stroke
	Risk factors
内容	Terada H., Nakamura K., Fujita S., et al. Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study. Thrombosis Research 254, 109455 (2025); https://doi.org/10.1016/j.thromres.2025.109455.
抄録	Background: Patients with cancer have an elevated risk of ischemic stroke, which can interrupt cancer treatment and worsen survival outcomes. However, epidemiological data on stroke incidence and risk factors in this population remain limited. Methods: We conducted a retrospective observational study of 35,862 patients with cancer registered at the University of Osaka Hospital between 2007 and 2020. Patients were followed for one year after cancer diagnosis to evaluate the cumulative incidence of ischemic stroke, accounting for death as a competing risk. Risk factors were assessed using the Fine and Gray competing risk model, with subdistribution hazard ratios (SHRs) and their 95 % confidence intervals (CIs) calculated. Results: During the study period, 188 patients experienced a stroke. Of these, ischemic stroke was the most common type, occurring in 143 patients (76.1 %), followed by intracerebral hemorrhage in 38 patients (20.2 %) and subarachnoid hemorrhage in 7 patients (3.7 %). The 1-year cumulative incidence of ischemic stroke was 0.42 %. In multivariable analysis, independent risk factors for ischemic stroke included older age (adjusted SHR, 1.01; 95 % CI, 1.00–1.03), hypertension (1.59; 95 % CI, 1.10–2.30), dyslipidemia (1.60; 95 % CI, 1.09–2.36), atrial fibrillation (2.42; 95 % CI, 1.54–3.81), and advanced stages (1.74; 95 % CI, 1.12–2.70). Elevated leukocyte count (≥11,000/μL) and platelet count (≥350,000/μL) at cancer diagnosis were also independent predictors of ischemic stroke. Conclusion: Our findings suggest that older age, hypertension, dyslipidemia, atrial fibrillation, advanced stages, and elevated leukocyte and platelet count could represent potential risk factors for ischemic stroke in patients with cancer.
出版者	Elsevier Ltd
収録物名	Thrombosis Research
巻(号)	254
ページ	109455
刊行年月	2025-10-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102878
PISSN	00493848
eISSN	18792472
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.thromres.2025.109455
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Thrombosis Research. 2025, 254, p. 109455
DC.title	Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study
DC.creator	Terada, Hiroaki
	Nakamura, Kenji
	Fujita, Shoto
	Gon, Yasufumi
	Kawano, Tomohiro
	Kitano, Takaya
	Takasugi, Junji
	Kanki, Hideaki
	Zha, Ling
	Komatsu, Masayo
	Kitamura, Tetsuhisa
	Sasaki, Tsutomu
DC.publisher	Elsevier Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-10-01
DC.identifier	https://doi.org/10.1016/j.thromres.2025.109455
DC.subject	Cancer
	Ischemic stroke
	Risk factors
DC.description	Terada H., Nakamura K., Fujita S., et al. Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study. Thrombosis Research 254, 109455 (2025); https://doi.org/10.1016/j.thromres.2025.109455.
DCTERMS.abstract	Background: Patients with cancer have an elevated risk of ischemic stroke, which can interrupt cancer treatment and worsen survival outcomes. However, epidemiological data on stroke incidence and risk factors in this population remain limited. Methods: We conducted a retrospective observational study of 35,862 patients with cancer registered at the University of Osaka Hospital between 2007 and 2020. Patients were followed for one year after cancer diagnosis to evaluate the cumulative incidence of ischemic stroke, accounting for death as a competing risk. Risk factors were assessed using the Fine and Gray competing risk model, with subdistribution hazard ratios (SHRs) and their 95 % confidence intervals (CIs) calculated. Results: During the study period, 188 patients experienced a stroke. Of these, ischemic stroke was the most common type, occurring in 143 patients (76.1 %), followed by intracerebral hemorrhage in 38 patients (20.2 %) and subarachnoid hemorrhage in 7 patients (3.7 %). The 1-year cumulative incidence of ischemic stroke was 0.42 %. In multivariable analysis, independent risk factors for ischemic stroke included older age (adjusted SHR, 1.01; 95 % CI, 1.00–1.03), hypertension (1.59; 95 % CI, 1.10–2.30), dyslipidemia (1.60; 95 % CI, 1.09–2.36), atrial fibrillation (2.42; 95 % CI, 1.54–3.81), and advanced stages (1.74; 95 % CI, 1.12–2.70). Elevated leukocyte count (≥11,000/μL) and platelet count (≥350,000/μL) at cancer diagnosis were also independent predictors of ischemic stroke. Conclusion: Our findings suggest that older age, hypertension, dyslipidemia, atrial fibrillation, advanced stages, and elevated leukocyte and platelet count could represent potential risk factors for ischemic stroke in patients with cancer.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102878
citation_title	Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study
citation_author	Terada, Hiroaki
	Nakamura, Kenji
	Fujita, Shoto
	Gon, Yasufumi
	Kawano, Tomohiro
	Kitano, Takaya
	Takasugi, Junji
	Kanki, Hideaki
	Zha, Ling
	Komatsu, Masayo
	Kitamura, Tetsuhisa
	Sasaki, Tsutomu
citation_publisher	Elsevier Ltd
citation_language	英語
citation_date	2025-10-01
citation_journal_title	Thrombosis Research
citation_volume	254
citation_firstpage	109455
citation_doi	https://doi.org/10.1016/j.thromres.2025.109455
citation_public_url	https://hdl.handle.net/11094/102878

Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study

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