Sex differences in placental structure and gene expression in ICR mice during embryonic development

Man, Xinyi; Usui, Noriyoshi; Doi, Miyuki; Shimada, Shoichi

doi:https://doi.org/10.1038/s41598-025-10476-2

Sex differences in placental structure and gene expression in ICR mice during embryonic development

Man, Xinyi; Usui, Noriyoshi; Doi, Miyuki et al.

Scientific Reports, 2025, 15(1), 24067

アクセス数:9件（2025-12-03 09:53 集計）

固定URL: https://hdl.handle.net/11094/102899

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タイトル	Sex differences in placental structure and gene expression in ICR mice during embryonic development
著者	著者名 Man, Xinyi
	NRID 1000000784076 1000000784076 ORCID 0000-0001-8079-8013 0000-0001-8079-8013 researchmap permalink noriyoshiusui noriyoshiusui Scopus Author ID 56404181300 56404181300 著者名 Usui, Noriyoshi
	NRID 1000080954007 1000080954007 researchmap permalink doim26 doim26 著者名 Doi, Miyuki
	NRID 1000020216063 1000020216063 ORCID 0000-0001-5369-1069 0000-0001-5369-1069 researchmap permalink 556shimada 556shimada Scopus Author ID 35452177800 35452177800 著者名 Shimada, Shoichi
キーワード等	Decidua
	Junctional zone
	Labyrinth
	Placental development
	Sex difference
	Trophoblast
内容	Man X., Usui N., Doi M., et al. Sex differences in placental structure and gene expression in ICR mice during embryonic development. Scientific Reports 15, 24067 (2025); https://doi.org/10.1038/s41598-025-10476-2.
抄録	The placenta is a vital organ for fetal development, providing structural support and mediating both nutrient exchange and maternal–fetal immune interactions. However, there are many aspects of murine placental development, which are used as a model organism, that are not fully understood compared to humans. In this study, we examined sex differences in placental development in ICR mice, a commonly used outbred strain, by analyzing the junctional zone (JZ) and labyrinth (LAB) from embryonic day (E) 8.5 to E18.5. At E14.5, the JZ area and its proportion relative to the total placental area (JZ + LAB) were significantly larger in females than in males. Consistently, expression levels of JZ-associated genes were also higher in female placentas at this stage. In contrast, such sex differences in placental morphology and gene expression were not observed in C57BL/6J mice, suggesting that observed features are unique to the ICR strain. Collectively, our findings demonstrate a female-biased expansion of the JZ in ICR mice at mid-gestation and underscore the presence of strain-specific patterns in sex-dependent placental development.
出版者	Nature Research
収録物名	Scientific Reports
巻(号)	15(1)
ページ	24067
刊行年月	2025-07-05
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102899
eISSN	20452322
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41598-025-10476-2
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15(1), p. 24067
DC.title	Sex differences in placental structure and gene expression in ICR mice during embryonic development
DC.creator	Man, Xinyi
	Usui, Noriyoshi
	Doi, Miyuki
	Shimada, Shoichi
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-05
DC.identifier	https://doi.org/10.1038/s41598-025-10476-2
DC.subject	Decidua
	Junctional zone
	Labyrinth
	Placental development
	Sex difference
	Trophoblast
DC.description	Man X., Usui N., Doi M., et al. Sex differences in placental structure and gene expression in ICR mice during embryonic development. Scientific Reports 15, 24067 (2025); https://doi.org/10.1038/s41598-025-10476-2.
DCTERMS.abstract	The placenta is a vital organ for fetal development, providing structural support and mediating both nutrient exchange and maternal–fetal immune interactions. However, there are many aspects of murine placental development, which are used as a model organism, that are not fully understood compared to humans. In this study, we examined sex differences in placental development in ICR mice, a commonly used outbred strain, by analyzing the junctional zone (JZ) and labyrinth (LAB) from embryonic day (E) 8.5 to E18.5. At E14.5, the JZ area and its proportion relative to the total placental area (JZ + LAB) were significantly larger in females than in males. Consistently, expression levels of JZ-associated genes were also higher in female placentas at this stage. In contrast, such sex differences in placental morphology and gene expression were not observed in C57BL/6J mice, suggesting that observed features are unique to the ICR strain. Collectively, our findings demonstrate a female-biased expansion of the JZ in ICR mice at mid-gestation and underscore the presence of strain-specific patterns in sex-dependent placental development.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102899
citation_title	Sex differences in placental structure and gene expression in ICR mice during embryonic development
citation_author	Man, Xinyi
	Usui, Noriyoshi
	Doi, Miyuki
	Shimada, Shoichi
citation_publisher	Nature Research
citation_language	英語
citation_date	2025-07-05
citation_journal_title	Scientific Reports
citation_volume	15
citation_issue	1
citation_firstpage	24067
citation_doi	https://doi.org/10.1038/s41598-025-10476-2
citation_public_url	https://hdl.handle.net/11094/102899

Sex differences in placental structure and gene expression in ICR mice during embryonic development

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