Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2

Baba, Satoshi; Hayashi, Hiroki; Yoshida, Shota; Yin, Nanxiang; Shimamura, Munehisa; Morishita, Ryuichi; Rakugi, Hiromi; Nakagami, Hironori; Yamamoto, Koichi

doi:https://doi.org/10.1016/j.isci.2025.112542

Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2

Baba, Satoshi; Hayashi, Hiroki; Yoshida, Shota et al.

iScience, 2025, 28(6), 112542

アクセス数:10件（2025-11-07 08:47 集計）

固定URL: https://hdl.handle.net/11094/102910

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タイトル	Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2
著者	著者名 Baba, Satoshi
	NRID 1000020813364 1000020813364 researchmap permalink hayashi-hiro hayashi-hiro Scopus Author ID 55702932900 55702932900 著者名 Hayashi, Hiroki
	著者名 Yoshida, Shota
	著者名 Yin, Nanxiang
	NRID 1000060422317 1000060422317 ORCID 0000-0003-0374-0787 0000-0003-0374-0787 researchmap permalink read8359 read8359 Scopus Author ID 7102059307 7102059307 著者名 Shimamura, Munehisa
	NRID 1000040291439 1000040291439 researchmap permalink read0051652 read0051652 Scopus Author ID 7102241494 7102241494 著者名 Morishita, Ryuichi
	NRID 1000020252679 1000020252679 ORCID 0000-0001-6508-4338 0000-0001-6508-4338 researchmap permalink read0042763 read0042763 Scopus Author ID 57202699453 57202699453 著者名 Rakugi, Hiromi
	NRID 1000020325369 1000020325369 ORCID 0000-0003-4494-3601 0000-0003-4494-3601 researchmap permalink hironorinakagami hironorinakagami Scopus Author ID 7006290279 7006290279 著者名 Nakagami, Hironori
	NRID 1000000528424 1000000528424 ORCID 0000-0003-0107-9315 0000-0003-0107-9315 researchmap permalink kymt0410 kymt0410 Scopus Author ID 55624482466 55624482466 著者名 Yamamoto, Koichi
キーワード等	Immunology
キーワード等	Virology
内容	Baba S., Hayashi H., Yoshida S., et al. Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2. iScience 28, 112542 (2025); https://doi.org/10.1016/j.isci.2025.112542.
抄録	Follicular helper T (Tfh) cells are a subset of CD4+ T cells that help B cells to produce high-affinity antibodies. Efficient Tfh cell induction by vaccines is critical for protective efficacy against diseases. A Tfh epitope, identified from the SARS-CoV-2 spike protein, has been shown to bind to the corresponding HLA and activates Tfh cells. Here, we assessed the efficacy of a peptide vaccine conjugated with SARS-CoV-2 Tfh epitope against experimental hypertension in a mouse model. The Tfh-angiotensin II (Tfh-Ang II) vaccine activated Tfh and germinal center B cells and induced antibodies against Ang II, thereby suppressing hypertension. However, Ang II-specific autoreactive T cells were not induced. Interestingly, Tfh-Ang II-induced antibody production was enhanced by SARS-CoV-2 spike priming. Moreover, human peripheral blood mononuclear cells from individuals vaccinated with COVID-19 mRNA vaccine were activated by Tfh epitope. Collectively, the SARS-CoV-2 spike-derived universal Tfh epitope may be effective for peptide-based vaccine development.
出版者	Elsevier Inc.
収録物名	iScience
巻(号)	28(6)
ページ	112542
刊行年月	2025-05-13
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102910
eISSN	25890042
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.isci.2025.112542
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	iScience. 2025, 28(6), p. 112542
DC.title	Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2
DC.creator	Baba, Satoshi
	Hayashi, Hiroki
	Yoshida, Shota
	Yin, Nanxiang
	Shimamura, Munehisa
	Morishita, Ryuichi
	Rakugi, Hiromi
	Nakagami, Hironori
	Yamamoto, Koichi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-13
DC.identifier	https://doi.org/10.1016/j.isci.2025.112542
DC.subject	Immunology
DC.subject	Virology
DC.description	Baba S., Hayashi H., Yoshida S., et al. Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2. iScience 28, 112542 (2025); https://doi.org/10.1016/j.isci.2025.112542.
DCTERMS.abstract	Follicular helper T (Tfh) cells are a subset of CD4+ T cells that help B cells to produce high-affinity antibodies. Efficient Tfh cell induction by vaccines is critical for protective efficacy against diseases. A Tfh epitope, identified from the SARS-CoV-2 spike protein, has been shown to bind to the corresponding HLA and activates Tfh cells. Here, we assessed the efficacy of a peptide vaccine conjugated with SARS-CoV-2 Tfh epitope against experimental hypertension in a mouse model. The Tfh-angiotensin II (Tfh-Ang II) vaccine activated Tfh and germinal center B cells and induced antibodies against Ang II, thereby suppressing hypertension. However, Ang II-specific autoreactive T cells were not induced. Interestingly, Tfh-Ang II-induced antibody production was enhanced by SARS-CoV-2 spike priming. Moreover, human peripheral blood mononuclear cells from individuals vaccinated with COVID-19 mRNA vaccine were activated by Tfh epitope. Collectively, the SARS-CoV-2 spike-derived universal Tfh epitope may be effective for peptide-based vaccine development.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102910
citation_title	Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2
citation_author	Baba, Satoshi
	Hayashi, Hiroki
	Yoshida, Shota
	Yin, Nanxiang
	Shimamura, Munehisa
	Morishita, Ryuichi
	Rakugi, Hiromi
	Nakagami, Hironori
	Yamamoto, Koichi
citation_publisher	Elsevier Inc.
citation_language	英語
citation_date	2025-05-13
citation_journal_title	iScience
citation_volume	28
citation_issue	6
citation_firstpage	112542
citation_doi	https://doi.org/10.1016/j.isci.2025.112542
citation_public_url	https://hdl.handle.net/11094/102910

Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2

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