An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells

Kajitani, Kenji; Ohtani, Tomohito; Higuchi, Rie; Chimura, Misato; Sera, Fusako; Tsai, Chia Hung Dylan; Ueda, Yasutaka; Nishimura, Jun Ichi; Sakata, Yasushi

doi:https://doi.org/10.1038/s41598-025-05483-2

An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells

Kajitani, Kenji; Ohtani, Tomohito; Higuchi, Rie et al.

Scientific Reports, 2025, 15(1), 19994

アクセス数:8件（2025-11-16 03:53 集計）

固定URL: https://hdl.handle.net/11094/102918

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タイトル	An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells
著者	ORCID 0009-0004-8612-7607 0009-0004-8612-7607 Scopus Author ID 57204035566 57204035566 著者名 Kajitani, Kenji
	NRID 1000030623897 1000030623897 ORCID 0000-0002-2963-7895 0000-0002-2963-7895 researchmap permalink tohtani tohtani Scopus Author ID 57932819800 57932819800 著者名 Ohtani, Tomohito
	著者名 Higuchi, Rie
	NRID 1000080815506 1000080815506 ORCID 0000-0003-3674-9171 0000-0003-3674-9171 researchmap permalink mstcmr mstcmr Scopus Author ID 56203376800 56203376800 著者名 Chimura, Misato
	NRID 1000070794139 1000070794139 ORCID 0000-0002-9260-6901 0000-0002-9260-6901 researchmap permalink fsera fsera Scopus Author ID 57196563132 57196563132 著者名 Sera, Fusako
	著者名 Tsai, Chia Hung Dylan
	NRID 1000030533848 1000030533848 ORCID 0000-0003-1562-1013 0000-0003-1562-1013 researchmap permalink PNH_research_maro PNH_research_maro Scopus Author ID 56215028600 56215028600 著者名 Ueda, Yasutaka
	NRID 1000080464246 1000080464246 researchmap permalink read0054905 read0054905 Scopus Author ID 36498385500 36498385500 著者名 Nishimura, Jun Ichi
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 著者名 Sakata, Yasushi
キーワード等	Deformability
	Ferritin
	Iron deficiency
	Morphology
	Red blood cell
内容	Kajitani K., Ohtani T., Higuchi R., et al. An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells. Scientific Reports 15, 19994 (2025); https://doi.org/10.1038/s41598-025-05483-2.
抄録	The deformability of red blood cells (RBCs) is essential for peripheral circulation and RBC survival and is reportedly altered in several diseases. However, its detail in iron-deficiency (ID) anemia remains poorly understood. We investigated the association between ID and RBC deformability in 120 participants classified into four groups according to their ferritin and hemoglobin levels: non-ID/non-anemia (n = 61), ID/non-anemia (n = 32), ID/anemia (n = 15), and non-ID/anemia (n = 12). In the analysis using the established on-chip deformability checker, the normalized transit velocity of RBCs through the peripheral-vessel constriction models was significantly higher in the ID/anemia group than in the other groups. The RBC deformability index (RDI), derived from the normalized transit velocity and degree of RBC deformation, was highest in the ID/anemia group, followed by the ID/non-anemia group. The RDI was negatively correlated with log10 ferritin levels (r = -0.66, p < 0.01), even after adjusting for hemoglobin levels. Lower log10 ferritin levels correlated with thinner, more oval-shaped RBCs and lower internal viscosity. These RBC characteristics were significantly associated with a higher RDI. These results suggest that, among several known determinants of RBC deformability, RBC morphology and internal viscosity are altered in ID, resulting in higher deformability.
出版者	Nature Research
収録物名	Scientific Reports
巻(号)	15(1)
ページ	19994
刊行年月	2025-06-06
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102918
eISSN	20452322
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41598-025-05483-2
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15(1), p. 19994
DC.title	An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells
DC.creator	Kajitani, Kenji
	Ohtani, Tomohito
	Higuchi, Rie
	Chimura, Misato
	Sera, Fusako
	Tsai, Chia Hung Dylan
	Ueda, Yasutaka
	Nishimura, Jun Ichi
	Sakata, Yasushi
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-06-06
DC.identifier	https://doi.org/10.1038/s41598-025-05483-2
DC.subject	Deformability
	Ferritin
	Iron deficiency
	Morphology
	Red blood cell
DC.description	Kajitani K., Ohtani T., Higuchi R., et al. An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells. Scientific Reports 15, 19994 (2025); https://doi.org/10.1038/s41598-025-05483-2.
DCTERMS.abstract	The deformability of red blood cells (RBCs) is essential for peripheral circulation and RBC survival and is reportedly altered in several diseases. However, its detail in iron-deficiency (ID) anemia remains poorly understood. We investigated the association between ID and RBC deformability in 120 participants classified into four groups according to their ferritin and hemoglobin levels: non-ID/non-anemia (n = 61), ID/non-anemia (n = 32), ID/anemia (n = 15), and non-ID/anemia (n = 12). In the analysis using the established on-chip deformability checker, the normalized transit velocity of RBCs through the peripheral-vessel constriction models was significantly higher in the ID/anemia group than in the other groups. The RBC deformability index (RDI), derived from the normalized transit velocity and degree of RBC deformation, was highest in the ID/anemia group, followed by the ID/non-anemia group. The RDI was negatively correlated with log10 ferritin levels (r = -0.66, p < 0.01), even after adjusting for hemoglobin levels. Lower log10 ferritin levels correlated with thinner, more oval-shaped RBCs and lower internal viscosity. These RBC characteristics were significantly associated with a higher RDI. These results suggest that, among several known determinants of RBC deformability, RBC morphology and internal viscosity are altered in ID, resulting in higher deformability.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102918
citation_title	An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells
citation_author	Kajitani, Kenji
	Ohtani, Tomohito
	Higuchi, Rie
	Chimura, Misato
	Sera, Fusako
	Tsai, Chia Hung Dylan
	Ueda, Yasutaka
	Nishimura, Jun Ichi
	Sakata, Yasushi
citation_publisher	Nature Research
citation_language	英語
citation_date	2025-06-06
citation_journal_title	Scientific Reports
citation_volume	15
citation_issue	1
citation_firstpage	19994
citation_doi	https://doi.org/10.1038/s41598-025-05483-2
citation_public_url	https://hdl.handle.net/11094/102918

An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells

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