Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis

Taya, Naohiro; Katakami, Naoto; Omori, Kazuo; Hosoe, Shigero; Watanabe, Hirotaka; Takahara, Mitsuyoshi; Miyashita, Kazuyuki; Konya, Yutaka; Obara, Sachiko; Hidaka, Ayako; Nakao, Motonao; Takahashi, Masatomo; Izumi, Yoshihiro; Bamba, Takeshi; Shimomura, Iichiro

doi:https://doi.org/10.3390/ijms26146977

Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis

Taya, Naohiro; Katakami, Naoto; Omori, Kazuo et al.

International Journal of Molecular Sciences, 2025, 26(14), 6977

アクセス数:39件（2025-12-05 15:46 集計）

固定URL: https://hdl.handle.net/11094/102933

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タイトル	Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis
著者	NRID 1000000991225 1000000991225 researchmap permalink n-taya n-taya Scopus Author ID 57208973904 57208973904 著者名 Taya, Naohiro
	NRID 1000010403049 1000010403049 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 著者名 Katakami, Naoto
	著者名 Omori, Kazuo
	著者名 Hosoe, Shigero
	著者名 Watanabe, Hirotaka
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 著者名 Takahara, Mitsuyoshi
	NRID 1000030795183 1000030795183 ORCID 0000-0001-7499-9919 0000-0001-7499-9919 researchmap permalink kmiyas kmiyas Scopus Author ID 57192808962 57192808962 著者名 Miyashita, Kazuyuki
	著者名 Konya, Yutaka
	著者名 Obara, Sachiko
	著者名 Hidaka, Ayako
	著者名 Nakao, Motonao
	NRID 1000030844419 1000030844419 著者名 Takahashi, Masatomo
	NRID 1000070622166 1000070622166 著者名 Izumi, Yoshihiro
	NRID 1000010432444 1000010432444 著者名 Bamba, Takeshi
	NRID 1000060346145 1000060346145 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 著者名 Shimomura, Iichiro
キーワード等	atherosclerosis
	diacylglycerol
	intima-media thickness
	lipidomics
	type 2 diabetes
内容	Taya N., Katakami N., Omori K., et al. Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis. International Journal of Molecular Sciences 26, 6977 (2025); https://doi.org/10.3390/ijms26146977.
抄録	Abnormalities in plasma lipoproteins observed in patients with diabetes promote atherosclerosis. However, the association between various lipid species and classes and atherosclerosis remains unclear. Here, we aimed to identify the plasma lipid characteristics associated with atherosclerosis progression in patients with diabetes. We performed semi-targeted lipidomic analysis of fasting plasma samples using supercritical fluid chromatography coupled with mass spectrometry in two independent patient groups with type 2 diabetes (n = 223 and 31) and evaluated cross-sectional associations between plasma lipids and carotid intima-media thickness (CIMT). Ten plasma lipid species, including eight diacylglycerols (DGs), and total DG levels were significantly associated with CIMT in both groups. Patients of the former group were partly observed for 5 years, and we investigated associations between DGs and CIMT progression in these patients (n = 101). As a result, 22 DGs among the 26 identified DGs and total DG (β = 0.398, p < 0.001) were significantly associated with the annual change in CIMT. Furthermore, plasma DG levels improved the predictive ability for CIMT progression, with an adjusted R-squared increase of 0.105 [95% confidence interval: 0.010, 0.232] in the models. Plasma DGs are associated with CIMT progression in patients with type 2 diabetes. Measurement of total plasma DG levels may be beneficial in assessing the risk of atherosclerosis progression.
出版者	Multidisciplinary Digital Publishing Institute (MDPI)
収録物名	International Journal of Molecular Sciences
巻(号)	26(14)
ページ	6977
刊行年月	2025-07-20
言語	英語
ハンドルURL	https://hdl.handle.net/11094/102933
PISSN	16616596
eISSN	14220067
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/ijms26146977
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2025, 26(14), p. 6977
DC.title	Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis
DC.creator	Taya, Naohiro
	Katakami, Naoto
	Omori, Kazuo
	Hosoe, Shigero
	Watanabe, Hirotaka
	Takahara, Mitsuyoshi
	Miyashita, Kazuyuki
	Konya, Yutaka
	Obara, Sachiko
	Hidaka, Ayako
	Nakao, Motonao
	Takahashi, Masatomo
	Izumi, Yoshihiro
	Bamba, Takeshi
	Shimomura, Iichiro
DC.publisher	Multidisciplinary Digital Publishing Institute (MDPI)
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-20
DC.identifier	https://doi.org/10.3390/ijms26146977
DC.subject	atherosclerosis
	diacylglycerol
	intima-media thickness
	lipidomics
	type 2 diabetes
DC.description	Taya N., Katakami N., Omori K., et al. Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis. International Journal of Molecular Sciences 26, 6977 (2025); https://doi.org/10.3390/ijms26146977.
DCTERMS.abstract	Abnormalities in plasma lipoproteins observed in patients with diabetes promote atherosclerosis. However, the association between various lipid species and classes and atherosclerosis remains unclear. Here, we aimed to identify the plasma lipid characteristics associated with atherosclerosis progression in patients with diabetes. We performed semi-targeted lipidomic analysis of fasting plasma samples using supercritical fluid chromatography coupled with mass spectrometry in two independent patient groups with type 2 diabetes (n = 223 and 31) and evaluated cross-sectional associations between plasma lipids and carotid intima-media thickness (CIMT). Ten plasma lipid species, including eight diacylglycerols (DGs), and total DG levels were significantly associated with CIMT in both groups. Patients of the former group were partly observed for 5 years, and we investigated associations between DGs and CIMT progression in these patients (n = 101). As a result, 22 DGs among the 26 identified DGs and total DG (β = 0.398, p < 0.001) were significantly associated with the annual change in CIMT. Furthermore, plasma DG levels improved the predictive ability for CIMT progression, with an adjusted R-squared increase of 0.105 [95% confidence interval: 0.010, 0.232] in the models. Plasma DGs are associated with CIMT progression in patients with type 2 diabetes. Measurement of total plasma DG levels may be beneficial in assessing the risk of atherosclerosis progression.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102933
citation_title	Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis
citation_author	Taya, Naohiro
	Katakami, Naoto
	Omori, Kazuo
	Hosoe, Shigero
	Watanabe, Hirotaka
	Takahara, Mitsuyoshi
	Miyashita, Kazuyuki
	Konya, Yutaka
	Obara, Sachiko
	Hidaka, Ayako
	Nakao, Motonao
	Takahashi, Masatomo
	Izumi, Yoshihiro
	Bamba, Takeshi
	Shimomura, Iichiro
citation_publisher	Multidisciplinary Digital Publishing Institute (MDPI)
citation_language	英語
citation_date	2025-07-20
citation_journal_title	International Journal of Molecular Sciences
citation_volume	26
citation_issue	14
citation_firstpage	6977
citation_doi	https://doi.org/10.3390/ijms26146977
citation_public_url	https://hdl.handle.net/11094/102933

Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis

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