Kinase-dependent regulation of ciliary protein transport and its implications for therapy

Chaya, Taro; Ayano, Yuri; Furukawa, Takahisa

Frontiers in Molecular Biosciences, 2025, 12, 1638737

アクセス数:19件（2025-12-04 19:39 集計）

固定URL: https://hdl.handle.net/11094/102937

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タイトル
Kinase-dependent regulation of ciliary protein transport and its implications for therapy
著者
NRID
1000050747087 1000050747087
ORCID
0000-0001-5562-8733 0000-0001-5562-8733
researchmap permalink
chaya chaya
Scopus Author ID
37094720600 37094720600
著者名
Chaya, Taro
著者名
Ayano, Yuri
NRID
1000050260609 1000050260609
ORCID
0000-0003-4171-220X 0000-0003-4171-220X
researchmap permalink
read0083689 read0083689
Scopus Author ID
7403160171 7403160171
著者名
Furukawa, Takahisa
キーワード等
ciliary tip
CILK1
ICK
MAK
retinitis pigmentosa
内容
Chaya T., Ayano Y., Furukawa T.. Kinase-dependent regulation of ciliary protein transport and its implications for therapy. Frontiers in Molecular Biosciences 12, 1638737 (2025); https://doi.org/10.3389/fmolb.2025.1638737.
抄録
Primary cilia are evolutionarily conserved microtubule-based structures that extend from the surfaces of many different cell types and decode a wide range of extracellular chemical and physical stimuli. Ciliary defects cause human diseases, termed ciliopathies, which are characterized by a variety of symptoms, such as developmental and sensory abnormalities. The formation and function of primary cilia depend on intraflagellar transport (IFT), which is a bidirectional protein transport system coordinated by three multi-subunit protein complexes with kinesin and dynein motors along the ciliary axoneme. Accumulating evidence has demonstrated that several serine-threonine kinases play key roles in the regulation of IFT. Here, we review the current understanding of the roles of these kinases during the IFT process, as well as their regulatory mechanisms, physiological and pathophysiological significance, and potential to treat ciliopathies and age-related obesity.
出版者
Frontiers Media SA
収録物名
Frontiers in Molecular Biosciences
巻(号)
12
ページ
1638737
刊行年月
2025-06-25
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102937
eISSN
2296889X
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.3389/fmolb.2025.1638737
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article