The Impact of Polyploid Giant Cancer Cells: The Root of Stress Resilience

Ogawa, Yuta; Fisher, Lydia; Matsumoto, Tomonori

Cancer Science, 2025

アクセス数:103件（2026-02-16 07:25 集計）

固定URL: https://hdl.handle.net/11094/102943

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タイトル
The Impact of Polyploid Giant Cancer Cells: The Root of Stress Resilience
著者
著者名
Ogawa, Yuta
著者名
Fisher, Lydia
NRID
1000040886610 1000040886610
ORCID
0000-0003-4483-2178 0000-0003-4483-2178
researchmap permalink
tomo_matsumoto tomo_matsumoto
Scopus Author ID
55628587431 55628587431
著者名
Matsumoto, Tomonori
キーワード等
adaptation
dormancy
genome redundancy
polyploid giant cancer cell
stress resilience
内容
Ogawa Y., Fisher L., Matsumoto T.. The Impact of Polyploid Giant Cancer Cells: The Root of Stress Resilience. Cancer Science (2025); https://doi.org/10.1111/cas.70191.
抄録
Polyploid giant cancer cells (PGCCs) represent a unique and distinct subset of cancer cells, characterized by either an abnormally large nucleus or the presence of multiple nuclei within a single cell. An increasing body of evidence indicates that PGCCs are closely linked to cancer progression, therapeutic resistance, and poor clinical prognosis. However, despite their distinctive morphology, no universal marker has been identified to reliably distinguish PGCCs from other cancer cell populations. This is at least partly because PGCCs arise across various cancer types in diverse contexts, displaying considerable variability in their gene expression profiles. Nevertheless, they share key features, most notably polyploidy and remarkable stress resilience. The exceptional stress resilience of PGCCs arises from various mechanisms, including genome redundancy buffering against genetic damage, dormancy induction for survival in harsh conditions, gene expression changes enhancing hypoxia resistance, and metabolic adaptations supporting growth in resource-limited environments. Collectively, these properties make PGCCs highly resilient to stress, facilitating their persistence and contributing to the progression and aggressiveness of cancer. In this review, we provide a comprehensive discussion of the mechanisms underlying PGCC stress resilience and explore its broader implications for cancer pathogenesis. Understanding these adaptive strategies may offer new insights into cancer biology and reveal potential therapeutic targets to mitigate PGCC-driven malignancy.
出版者
John Wiley and Sons Inc
収録物名
Cancer Science
刊行年月
2025-09-08
言語
英語
ハンドルURL
https://hdl.handle.net/11094/102943
PISSN
13479032
eISSN
13497006
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1111/cas.70191
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
© 2025 The Author(s). Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article