Ex Vivo Quantification of Calcification Stiffness in Aortic Stenosis: Biomechanical Data from Resected Human Valves

Shirakawa, Takashi; Shimamura, Kazuo; Maeda, Koichi; Yajima, Shin; Kawamura, Ai; Kawamura, Takuji; Yoshioka, Daisuke; Miyagawa, Shigeru

doi:https://doi.org/10.1007/s10439-025-03869-x

Ex Vivo Quantification of Calcification Stiffness in Aortic Stenosis: Biomechanical Data from Resected Human Valves

Shirakawa, Takashi; Shimamura, Kazuo; Maeda, Koichi et al.

Annals of Biomedical Engineering, 2025

アクセス数:400件（2026-02-16 16:45 集計）

固定URL: https://hdl.handle.net/11094/103273

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タイトル	Ex Vivo Quantification of Calcification Stiffness in Aortic Stenosis: Biomechanical Data from Resected Human Valves
著者	NRID 1000020975338 1000020975338 ORCID 0000-0001-7352-1876 0000-0001-7352-1876 Scopus Author ID 57189059781 57189059781 著者名 Shirakawa, Takashi
	NRID 1000010507205 1000010507205 researchmap permalink kazuo-shimamura kazuo-shimamura Scopus Author ID 35969640700 35969640700 著者名 Shimamura, Kazuo
	NRID 1000050644994 1000050644994 ORCID 0000-0002-1102-111X 0000-0002-1102-111X researchmap permalink koichi-maeda koichi-maeda Scopus Author ID 55318832600 55318832600 著者名 Maeda, Koichi
	NRID 1000080793249 1000080793249 ORCID 0000-0001-5058-0267 0000-0001-5058-0267 researchmap permalink s-yajima.surg1 s-yajima.surg1 Scopus Author ID 54407701900 54407701900 著者名 Yajima, Shin
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 著者名 Kawamura, Ai
	NRID 1000060839398 1000060839398 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 著者名 Kawamura, Takuji
	NRID 1000040645959 1000040645959 researchmap permalink d-yoshioka d-yoshioka Scopus Author ID 7003892845 7003892845 著者名 Yoshioka, Daisuke
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 著者名 Miyagawa, Shigeru
キーワード等	Aortic stenosis
	Calcification
	Compression test
	Mechanical stiffness
	Quantitative data
内容	The version of record of this article, first published in Annals of Biomedical Engineering (2025), is available online at Publisher’s website: https://doi.org/10.1007/s10439-025-03869-x
抄録	Purpose: Aortic stenosis (AS) is characterized by progressive calcification of the aortic valve. While imaging can assess the extent and localization of calcification, intraoperative findings suggest substantial variability in mechanical stiffness. Quantitative biomechanical evaluation is needed to inform optimized treatment strategies. We aimed to quantify the mechanical stiffness of calcified nodules in human AS. Methods: We performed ex vivo compression testing on 129 calcified nodules resected from 46 patients undergoing surgical aortic valve replacement for severe AS. Stress–strain relationships were measured to characterize the mechanical behavior of the nodules, and two stiffness parameters—compression strength (CS) and compression energy (CE)—were defined. These parameters were compared with the computed tomography (CT) density of the region from which each nodule was resected. Results: Calcified nodules exhibited wide variation in reactive stress, with maximum values in low strain regions ranging from 60 to 100-fold higher than the minimum. The stress–strain curves demonstrated three-phase pattern consisting of an initial increase, plateau phase, and steep rise in stress. The median CS increased from 0.38 MPa at 10% strain to 1.73 MPa at 50% strain, and median CE from 0.020 to 0.43 J/cm³ across the same range. The Pearson’s correlation coefficients between CT density and these parameters ranged from 0.291 to 0.454. Conclusion: Some nodules demonstrated marked reactive stress even at low strain levels, indicating strong resistance to compression with minimal deformation. This study provides reference data on the biomechanical stiffness of calcification in human AS.
出版者	Springer
収録物名	Annals of Biomedical Engineering
刊行年月	2025-10-09
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103273
PISSN	00906964
eISSN	15739686
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s10439-025-03869-x
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Annals of Biomedical Engineering. 2025
DC.title	Ex Vivo Quantification of Calcification Stiffness in Aortic Stenosis: Biomechanical Data from Resected Human Valves
DC.creator	Shirakawa, Takashi
	Shimamura, Kazuo
	Maeda, Koichi
	Yajima, Shin
	Kawamura, Ai
	Kawamura, Takuji
	Yoshioka, Daisuke
	Miyagawa, Shigeru
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-10-09
DC.identifier	https://doi.org/10.1007/s10439-025-03869-x
DC.subject	Aortic stenosis
	Calcification
	Compression test
	Mechanical stiffness
	Quantitative data
DC.description	The version of record of this article, first published in Annals of Biomedical Engineering (2025), is available online at Publisher’s website: https://doi.org/10.1007/s10439-025-03869-x
DCTERMS.abstract	Purpose: Aortic stenosis (AS) is characterized by progressive calcification of the aortic valve. While imaging can assess the extent and localization of calcification, intraoperative findings suggest substantial variability in mechanical stiffness. Quantitative biomechanical evaluation is needed to inform optimized treatment strategies. We aimed to quantify the mechanical stiffness of calcified nodules in human AS. Methods: We performed ex vivo compression testing on 129 calcified nodules resected from 46 patients undergoing surgical aortic valve replacement for severe AS. Stress–strain relationships were measured to characterize the mechanical behavior of the nodules, and two stiffness parameters—compression strength (CS) and compression energy (CE)—were defined. These parameters were compared with the computed tomography (CT) density of the region from which each nodule was resected. Results: Calcified nodules exhibited wide variation in reactive stress, with maximum values in low strain regions ranging from 60 to 100-fold higher than the minimum. The stress–strain curves demonstrated three-phase pattern consisting of an initial increase, plateau phase, and steep rise in stress. The median CS increased from 0.38 MPa at 10% strain to 1.73 MPa at 50% strain, and median CE from 0.020 to 0.43 J/cm³ across the same range. The Pearson’s correlation coefficients between CT density and these parameters ranged from 0.291 to 0.454. Conclusion: Some nodules demonstrated marked reactive stress even at low strain levels, indicating strong resistance to compression with minimal deformation. This study provides reference data on the biomechanical stiffness of calcification in human AS.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	103273
citation_title	Ex Vivo Quantification of Calcification Stiffness in Aortic Stenosis: Biomechanical Data from Resected Human Valves
citation_author	Shirakawa, Takashi
	Shimamura, Kazuo
	Maeda, Koichi
	Yajima, Shin
	Kawamura, Ai
	Kawamura, Takuji
	Yoshioka, Daisuke
	Miyagawa, Shigeru
citation_publisher	Springer
citation_language	英語
citation_date	2025-10-09
citation_journal_title	Annals of Biomedical Engineering
citation_doi	https://doi.org/10.1007/s10439-025-03869-x
citation_public_url	https://hdl.handle.net/11094/103273

Ex Vivo Quantification of Calcification Stiffness in Aortic Stenosis: Biomechanical Data from Resected Human Valves

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