Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers

Kashiwagi, Takafumi; Takata, So; Tanaka, Hidenori; Ikuta, Shoko; Totoki, Yasushi; Nakatani, Yoichiro; Inohara, Hidenori; Uzawa, Narikazu; Yachida, Shinichi

doi:https://doi.org/10.1111/cas.70205

Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers

Kashiwagi, Takafumi; Takata, So; Tanaka, Hidenori et al.

Cancer Science, 2025

アクセス数:363件（2026-02-15 21:48 集計）

固定URL: https://hdl.handle.net/11094/103276

閲覧可能ファイル

ファイル	フォーマット	利用条件	サイズ	閲覧回数	利用開始日	説明	information
CancerSci_2025_70205	pdf	なし	5.61 MB	18	2025.12.02

Creative Commons : 表示 - 非営利 - 改変禁止

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル	Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers
著者	ORCID 0009-0003-3635-6738 0009-0003-3635-6738 researchmap permalink 986436 986436 Scopus Author ID 59538096100 59538096100 著者名 Kashiwagi, Takafumi
	NRID 1000040977112 1000040977112 ORCID 0000-0002-8071-1077 0000-0002-8071-1077 researchmap permalink sotakata sotakata Scopus Author ID 57194768215 57194768215 著者名 Takata, So
	NRID 1000000804379 1000000804379 著者名 Tanaka, Hidenori
	著者名 Ikuta, Shoko
	NRID 1000010373333 1000010373333 ORCID 0000-0003-1876-6859 0000-0003-1876-6859 researchmap permalink ytotoki ytotoki Scopus Author ID 58966284600 58966284600 著者名 Totoki, Yasushi
	NRID 1000010847891 1000010847891 ORCID 0000-0001-7604-0242 0000-0001-7604-0242 researchmap permalink nakatani_yoichiro nakatani_yoichiro Scopus Author ID 8534216500 8534216500 著者名 Nakatani, Yoichiro
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 ORCID 0000-0003-4473-1203 0000-0003-4473-1203 著者名 Inohara, Hidenori
	NRID 1000030345285 1000030345285 ORCID 0000-0001-5390-6875 0000-0001-5390-6875 researchmap permalink read0212957 read0212957 Scopus Author ID 6603144046 6603144046 著者名 Uzawa, Narikazu
	NRID 1000020359920 1000020359920 ORCID 0000-0001-5507-4566 0000-0001-5507-4566 researchmap permalink read0210591 read0210591 Scopus Author ID 57226203270 57226203270 著者名 Yachida, Shinichi
キーワード等	DNA methylation
	gene expression
	immune profile analysis
	intertumor heterogeneity
	oral subsites
内容	Kashiwagi T., Takata S., Tanaka H., et al. Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers. Cancer Science (2025); https://doi.org/10.1111/cas.70205.
抄録	While the development of innovative drugs has improved the outcomes of various cancers in recent years, the number of patients with oral squamous cell carcinoma (OSCC) and mortality rates has not yet decreased significantly. This could be attributed to the prognostic and molecular differences occurring at different locations of cancer development. In this study, we conducted gene expression, DNA methylation, and tumor immunological analyses of gingival squamous cell carcinoma (GSCC) and tongue squamous cell carcinoma (TSCC) to elucidate the characteristic gene expression changes, their mechanisms, and tumor immune profiles. Gene expression analysis suggested that pathways related to the cell cycle and antibacterial humoral immunity were upregulated in GSCC, whereas immune response pathways were upregulated in TSCC. Additionally, high HOXC13 expression may be associated with GSCC prognosis. DNA methylation analysis revealed hypermethylation of the 3′ UTR of the HOXD11 gene, leading to increased expression in both GSCC and TSCC. In the tumor immune profile analysis, when comparing tumor and normal tissues in GSCC, the number of immune cells did not change significantly; however, the proportion of inflammatory cells, such as CD8+ T cells, changed. In TSCC, the number and percentage of inflammatory cells, such as T lymphocytes, increased in the tumor compared to those of normal tissues. These findings underscore the importance of understanding the characteristics of site-specific OSCC. Therefore, it is essential to establish standardized treatment protocols and develop novel therapeutic strategies tailored to each anatomical site of the tumor.
出版者	John Wiley and Sons Inc
収録物名	Cancer Science
刊行年月	2025-09-28
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103276
PISSN	13479032
eISSN	13497006
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/cas.70205
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Cancer Science. 2025
DC.title	Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers
DC.creator	Kashiwagi, Takafumi
	Takata, So
	Tanaka, Hidenori
	Ikuta, Shoko
	Totoki, Yasushi
	Nakatani, Yoichiro
	Inohara, Hidenori
	Uzawa, Narikazu
	Yachida, Shinichi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-09-28
DC.identifier	https://doi.org/10.1111/cas.70205
DC.subject	DNA methylation
	gene expression
	immune profile analysis
	intertumor heterogeneity
	oral subsites
DC.description	Kashiwagi T., Takata S., Tanaka H., et al. Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers. Cancer Science (2025); https://doi.org/10.1111/cas.70205.
DCTERMS.abstract	While the development of innovative drugs has improved the outcomes of various cancers in recent years, the number of patients with oral squamous cell carcinoma (OSCC) and mortality rates has not yet decreased significantly. This could be attributed to the prognostic and molecular differences occurring at different locations of cancer development. In this study, we conducted gene expression, DNA methylation, and tumor immunological analyses of gingival squamous cell carcinoma (GSCC) and tongue squamous cell carcinoma (TSCC) to elucidate the characteristic gene expression changes, their mechanisms, and tumor immune profiles. Gene expression analysis suggested that pathways related to the cell cycle and antibacterial humoral immunity were upregulated in GSCC, whereas immune response pathways were upregulated in TSCC. Additionally, high HOXC13 expression may be associated with GSCC prognosis. DNA methylation analysis revealed hypermethylation of the 3′ UTR of the HOXD11 gene, leading to increased expression in both GSCC and TSCC. In the tumor immune profile analysis, when comparing tumor and normal tissues in GSCC, the number of immune cells did not change significantly; however, the proportion of inflammatory cells, such as CD8+ T cells, changed. In TSCC, the number and percentage of inflammatory cells, such as T lymphocytes, increased in the tumor compared to those of normal tissues. These findings underscore the importance of understanding the characteristics of site-specific OSCC. Therefore, it is essential to establish standardized treatment protocols and develop novel therapeutic strategies tailored to each anatomical site of the tumor.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	103276
citation_title	Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers
citation_author	Kashiwagi, Takafumi
	Takata, So
	Tanaka, Hidenori
	Ikuta, Shoko
	Totoki, Yasushi
	Nakatani, Yoichiro
	Inohara, Hidenori
	Uzawa, Narikazu
	Yachida, Shinichi
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2025-09-28
citation_journal_title	Cancer Science
citation_doi	https://doi.org/10.1111/cas.70205
citation_public_url	https://hdl.handle.net/11094/103276

Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers

閲覧可能ファイル

論文情報

論文詳細を表示