Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report

Yamao, Noriko; Shimamoto, Hiroaki; Munshi, Maziahtul Zawani; Nishimura, Danielle Ayumi; Takagawa, Naoko; Assapattarapun, Varisa; Hirose, Katsutoshi; Oya, Kaori; Uchihashi, Toshihiro; Kreiborg, Sven; Mallya, Sanjay M.; Yang, Fan pei Gloria

doi:https://doi.org/10.1007/s11282-025-00875-6

Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report

Yamao, Noriko; Shimamoto, Hiroaki; Munshi, Maziahtul Zawani et al.

Oral Radiology, 2025

アクセス数:247件（2026-02-16 00:54 集計）

固定URL: https://hdl.handle.net/11094/103362

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タイトル	Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report
著者	著者名 Yamao, Noriko
	NRID 1000030448112 1000030448112 ORCID 0000-0001-5609-266X 0000-0001-5609-266X researchmap permalink read0127765 read0127765 Scopus Author ID 14026102500 14026102500 著者名 Shimamoto, Hiroaki
	著者名 Munshi, Maziahtul Zawani
	著者名 Nishimura, Danielle Ayumi
	著者名 Takagawa, Naoko
	著者名 Assapattarapun, Varisa
	NRID 1000000824898 1000000824898 ORCID 0000-0003-4148-1106 0000-0003-4148-1106 researchmap permalink -hirose -hirose Scopus Author ID 57190276392 57190276392 著者名 Hirose, Katsutoshi
	NRID 1000000779126 1000000779126 researchmap permalink 1-9ss 1-9ss Scopus Author ID 55325695400 55325695400 著者名 Oya, Kaori
	NRID 1000060757839 1000060757839 researchmap permalink 4891 4891 Scopus Author ID 35070472600 35070472600 著者名 Uchihashi, Toshihiro
	著者名 Kreiborg, Sven
	著者名 Mallya, Sanjay M.
	ORCID 0000-0001-6133-0706 0000-0001-6133-0706 Scopus Author ID 34972160300 34972160300 著者名 Yang, Fan pei Gloria
キーワード等	Bone formation
	Calcification
	Imaging diagnosis
	MDCT
	Mucoepidermoid carcinoma
内容	Yamao N., Shimamoto H., Munshi M.Z., et al. Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report. Oral Radiology , (2025); https://doi.org/10.1007/s11282-025-00875-6.
抄録	Mucoepidermoid carcinoma (MEC) is the most frequent salivary gland malignancy. Rarely, intra tumor bone formation may occur. To date there have been only two reports of MEC with bone formation in the oral and maxillofacial region. We report a case of MEC in the sublingual gland with intratumor bone formation involving a 78-year-old woman. The study presents the imaging findings of the lesion across multiple modalities. Multi-detector row computed tomography (MDCT) imaging revealed a 21 × 18 × 12 mm mass in the left side of floor of the mouth, containing multiple calcified-like high CT numbers (≥ 400 HU). Magnetic resonance imaging (MRI) revealed a 28 × 21 × 11 mm mass that was isointense to muscle on T1-weighted images, intermediate signal intensity on short tau inversion recovery (STIR) images and with heterogeneous contrast enhancement. In addition, multiple signal voids suspicious for calcification were observed inside the lesion. Ultrasonography showed a well-defined hypoechoic lesion within the left sublingual gland and multiple hyperreflective bodies with acoustic shadows inside the lesion. Histopathologically, the lesion was diagnosed as intermediate-grade MEC with bone formation inside the lesion. The identification of calcifications on the MDCT examination was a key prompt to further investigate the nature of the lesion.
出版者	Springer
収録物名	Oral Radiology
刊行年月	2025-11-05
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103362
PISSN	09116028
eISSN	16139674
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1007/s11282-025-00875-6
アクセス権	embargoed access
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11282-025-00875-6
	© The Authors under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology 2025.
	The full-text file will be made open to the public on 5 November 2026 in accordance with the publisher's policy.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Oral Radiology. 2025
DC.title	Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report
DC.creator	Yamao, Noriko
	Shimamoto, Hiroaki
	Munshi, Maziahtul Zawani
	Nishimura, Danielle Ayumi
	Takagawa, Naoko
	Assapattarapun, Varisa
	Hirose, Katsutoshi
	Oya, Kaori
	Uchihashi, Toshihiro
	Kreiborg, Sven
	Mallya, Sanjay M.
	Yang, Fan pei Gloria
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-11-05
DC.identifier	https://doi.org/10.1007/s11282-025-00875-6
DC.subject	Bone formation
	Calcification
	Imaging diagnosis
	MDCT
	Mucoepidermoid carcinoma
DC.description	Yamao N., Shimamoto H., Munshi M.Z., et al. Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report. Oral Radiology , (2025); https://doi.org/10.1007/s11282-025-00875-6.
DCTERMS.abstract	Mucoepidermoid carcinoma (MEC) is the most frequent salivary gland malignancy. Rarely, intra tumor bone formation may occur. To date there have been only two reports of MEC with bone formation in the oral and maxillofacial region. We report a case of MEC in the sublingual gland with intratumor bone formation involving a 78-year-old woman. The study presents the imaging findings of the lesion across multiple modalities. Multi-detector row computed tomography (MDCT) imaging revealed a 21 × 18 × 12 mm mass in the left side of floor of the mouth, containing multiple calcified-like high CT numbers (≥ 400 HU). Magnetic resonance imaging (MRI) revealed a 28 × 21 × 11 mm mass that was isointense to muscle on T1-weighted images, intermediate signal intensity on short tau inversion recovery (STIR) images and with heterogeneous contrast enhancement. In addition, multiple signal voids suspicious for calcification were observed inside the lesion. Ultrasonography showed a well-defined hypoechoic lesion within the left sublingual gland and multiple hyperreflective bodies with acoustic shadows inside the lesion. Histopathologically, the lesion was diagnosed as intermediate-grade MEC with bone formation inside the lesion. The identification of calcifications on the MDCT examination was a key prompt to further investigate the nature of the lesion.
DC.rights	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11282-025-00875-6
	© The Authors under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology 2025.
	The full-text file will be made open to the public on 5 November 2026 in accordance with the publisher's policy.
DC.format	103362
citation_title	Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report
citation_author	Yamao, Noriko
	Shimamoto, Hiroaki
	Munshi, Maziahtul Zawani
	Nishimura, Danielle Ayumi
	Takagawa, Naoko
	Assapattarapun, Varisa
	Hirose, Katsutoshi
	Oya, Kaori
	Uchihashi, Toshihiro
	Kreiborg, Sven
	Mallya, Sanjay M.
	Yang, Fan pei Gloria
citation_publisher	Springer
citation_language	英語
citation_date	2025-11-05
citation_journal_title	Oral Radiology
citation_doi	https://doi.org/10.1007/s11282-025-00875-6
citation_public_url	https://hdl.handle.net/11094/103362

Imaging diagnosis of mucoepidermoid carcinoma with intratumoral bone formation: a case report

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