Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Xiao, Linghao; Abe, Gabriela Laranjeira; Sasaki, Jun Ichi et al.

Advanced Healthcare Materials, 2025

アクセス数:108件（2026-02-16 12:11 集計）

固定URL: https://hdl.handle.net/11094/103460

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タイトル
Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections
著者
NRID
1000040975025 1000040975025
ORCID
0009-0009-0636-8635 0009-0009-0636-8635
researchmap permalink
xiaolinghao xiaolinghao
Scopus Author ID
57205750434 57205750434
著者名
Xiao, Linghao
NRID
1000030964952 1000030964952
ORCID
0000-0001-8843-1697 0000-0001-8843-1697
researchmap permalink
gabriela_abe gabriela_abe
Scopus Author ID
57192013857 57192013857
著者名
Abe, Gabriela Laranjeira
NRID
1000050530490 1000050530490
ORCID
0000-0002-0330-0397 0000-0002-0330-0397
researchmap permalink
Sasaki_JI Sasaki_JI
Scopus Author ID
36138008500 36138008500
著者名
Sasaki, Jun Ichi
NRID
1000050736246 1000050736246
ORCID
0000-0002-5270-4865 0000-0002-5270-4865
researchmap permalink
kitagawa_h kitagawa_h
Scopus Author ID
55267186700 55267186700
著者名
Kitagawa, Haruaki
NRID
1000020827430 1000020827430
著者名
Tsuboi, Ririko
NRID
1000010839202 1000010839202
ORCID
0000-0002-7690-2567 0000-0002-7690-2567
researchmap permalink
tomoki-kohno tomoki-kohno
Scopus Author ID
57214627603 57214627603
著者名
Kohno, Tomoki
NRID
1000080243244 1000080243244
ORCID
0000-0003-3655-4809 0000-0003-3655-4809
researchmap permalink
read0014210 read0014210
Scopus Author ID
55994423600 55994423600
著者名
Imazato, Satoshi
キーワード等
antibacterial effects
biomimetic bone substitute
carbonate apatite
gentamicin
neutrophils
内容
Xiao L., Abe G.L., Sasaki J.I., et al. Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections. Advanced Healthcare Materials , (2025); https://doi.org/10.1002/adhm.202503739.
抄録
Surgical site infections remain a critical concern in dental and orthopedic procedures. To combat surgical site infections, gentamicin-loaded carbonate apatite (GM-CAp) granules, a novel antibacterial biomimetic bone substitute is developed. GM-CAp granules rapidly release the loaded gentamicin, leading to swift suppression of bacteria and proactive prevention of infection. In vitro studies validate the bactericidal effects of GM-CAp granules against a spectrum of odontogenic bacteria. In vivo investigations confirm the effectiveness of GM-CAp in suppressing Staphylococcus aureus infection, mitigating inflammation, especially neutrophil recruitment, and stimulating bone regeneration. Transcriptomic analysis reveals that early-stage neutrophil dynamics may influence the inflammatory milieu and subsequent bone healing in the infected bone defect following CAp or GM-CAp implantation. Overall, GM-CAp granules represent a potential strategy for combating surgical site infections and increasing the success rate of bone healing in dental and orthopedic surgeries. Additionally, it is proposed that the status of early postoperative neutrophil recruitment may serve as a potential parameter for evaluating the antimicrobial efficacy of biomaterials.
出版者
John Wiley and Sons Inc
収録物名
Advanced Healthcare Materials
刊行年月
2025-10-26
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103460
PISSN
21922640
eISSN
21922659
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/adhm.202503739
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article