Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High-Risk Follicular Thyroid Carcinoma

Tanida, Masashi; Takashima, Tsuyoshi; Tahara, Shinichiro et al.

Cancer Science, 2025

アクセス数:188件（2026-02-05 15:52 集計）

固定URL: https://hdl.handle.net/11094/103469

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タイトル
Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High-Risk Follicular Thyroid Carcinoma
著者
ORCID
0009-0006-9016-0420 0009-0006-9016-0420
Scopus Author ID
57796101800 57796101800
著者名
Tanida, Masashi
ORCID
0000-0003-1362-3883 0000-0003-1362-3883
researchmap permalink
ts-takashima ts-takashima
Scopus Author ID
57216531234 57216531234
著者名
Takashima, Tsuyoshi
NRID
1000020792584 1000020792584
ORCID
0000-0001-6134-3275 0000-0001-6134-3275
researchmap permalink
s_tahara s_tahara
Scopus Author ID
57189030096 57189030096
著者名
Tahara, Shinichiro
NRID
1000000379257 1000000379257
ORCID
0009-0006-7636-5833 0009-0006-7636-5833
Scopus Author ID
22234528100 22234528100
著者名
Kohara, Masaharu
著者名
Kanai, Haruka
NRID
1000080434182 1000080434182
researchmap permalink
msuzukicgi msuzukicgi
Scopus Author ID
57199980789 57199980789
著者名
Suzuki, Masami
NRID
1000050632329 1000050632329
researchmap permalink
motoyukisuzuki motoyukisuzuki
Scopus Author ID
55505806400 55505806400
著者名
Suzuki, Motoyuki
著者名
Hirokawa, Mitsuyoshi
著者名
Suzuki, Ayana
著者名
Sato, Shinya
NRID
1000000346131 1000000346131
ORCID
0000-0002-4552-783X 0000-0002-4552-783X
researchmap permalink
read0092307 read0092307
Scopus Author ID
6506703054 6506703054
著者名
Okuzaki, Daisuke
NRID
1000040528791 1000040528791
ORCID
0000-0002-5124-0026 0000-0002-5124-0026
researchmap permalink
snojima snojima
Scopus Author ID
16224082000 16224082000
著者名
Nojima, Satoshi
NRID
1000050747037 1000050747037
ORCID
0000-0002-6753-1688 0000-0002-6753-1688
researchmap permalink
takahiromatsui takahiromatsui
Scopus Author ID
35176152500 35176152500
著者名
Matsui, Takahiro
NRID
1000000273657 1000000273657
ORCID
0000-0003-4473-1203 0000-0003-4473-1203
researchmap permalink
read0046473 read0046473
Scopus Author ID
7004501837 7004501837
著者名
Inohara, Hidenori
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
著者名
Morii, Eiichi
キーワード等
biomarkers
carbonic anhydrase 12
follicular thyroid carcinoma
lenvatinib
matrix metalloproteinase 2
内容
Tanida M., Takashima T., Tahara S., et al. Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High-Risk Follicular Thyroid Carcinoma. Cancer Science , (2025); https://doi.org/10.1111/cas.70248.
抄録
Follicular thyroid carcinoma is generally associated with a favorable prognosis; however, a subset of follicular thyroid carcinoma shows poor prognosis and frequent distant metastases, and this subset is referred to as high-risk follicular thyroid carcinoma. Difficulty in distinguishing high-risk from low-risk follicular thyroid carcinoma based on current diagnostic approaches leads to the overtreatment of patients with indolent disease. Therefore, the identification of novel biomarkers capable of reliably distinguishing high-risk follicular thyroid carcinoma is essential for accurate risk stratification. Such biomarkers may serve as therapeutic targets for metastatic follicular thyroid carcinoma. This study aimed to identify novel prognostic markers and therapeutic targets for high-risk follicular thyroid carcinoma. In this study, we conducted bulk ribonucleic acid sequencing of high-risk follicular thyroid carcinoma, including widely invasive subtypes and metastatic tumors, and we identified carbonic anhydrase 12 as a candidate biomarker. Immunohistochemical analysis revealed significantly higher carbonic anhydrase 12 expression in follicular thyroid carcinoma than in benign follicular adenomas, particularly in widely invasive and encapsulated angioinvasive subtypes. High carbonic anhydrase 12 expression was an independent predictor of poor disease-free survival, surpassing conventional clinicopathological parameters. Functional assays showed that carbonic anhydrase 12 promoted follicular thyroid carcinoma proliferation, invasion, and migration partly by regulating matrix metalloproteinase 2 expression. Furthermore, carbonic anhydrase 12 inhibitor U104 suppressed follicular thyroid carcinoma cell growth in a dose-dependent manner, and its combination with lenvatinib exerted synergistic antiproliferative effects. Collectively, these findings identified carbonic anhydrase 12 as a novel prognostic biomarker of follicular thyroid carcinoma and a promising therapeutic target.
出版者
John Wiley and Sons Inc
収録物名
Cancer Science
刊行年月
2025-11-10
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103469
PISSN
13479032
eISSN
13497006
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1111/cas.70248
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article