Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance

Ozawa, Takaaki; Nakagawa, Issei; Uchida, Yuuki; Abe, Mayuka; Macpherson, Tom; Yamashita, Yuichi; Hikida, Takatoshi

doi:https://doi.org/10.1038/s41538-025-00558-w

Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance

Ozawa, Takaaki; Nakagawa, Issei; Uchida, Yuuki et al.

npj Science of Food, 2025, 9, 197

アクセス数:82件（2026-02-15 23:05 集計）

固定URL: https://hdl.handle.net/11094/103488

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タイトル	Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance
著者	NRID 1000090625352 1000090625352 ORCID 0000-0003-3633-7062 0000-0003-3633-7062 researchmap permalink takaaki_ozawa takaaki_ozawa Scopus Author ID 56312563400 56312563400 著者名 Ozawa, Takaaki
	著者名 Nakagawa, Issei
	著者名 Uchida, Yuuki
	著者名 Abe, Mayuka
	NRID 1000040821898 1000040821898 ORCID 0000-0002-0250-1146 0000-0002-0250-1146 researchmap permalink macpherson macpherson Scopus Author ID 55330509300 55330509300 著者名 Macpherson, Tom
	NRID 1000040584131 1000040584131 著者名 Yamashita, Yuichi
	NRID 1000070421378 1000070421378 ORCID 0000-0002-8653-311X 0000-0002-8653-311X researchmap permalink hikida hikida Scopus Author ID 7006504625 7006504625 著者名 Hikida, Takatoshi
内容	Ozawa T., Nakagawa I., Uchida Y., et al. Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance. npj Science of Food 9, 197 (2025); https://doi.org/10.1038/s41538-025-00558-w.
抄録	Homeostatic imbalances elicit strong cravings, such as thirst and salt appetite, to restore equilibrium. Although midbrain dopaminergic neurons are known to encode the value of foods, their nutritional state-dependency remains unknown. Here, we show that the activity of the dopaminergic mesolimbic pathway flexibly expresses the positive and negative values of water and salt depending on the internal state in mice. Mice showed behavioral preference and aversion to water and salt depending on their internal water and sodium balance. Fiber photometry recordings revealed that dopamine neurons in the ventral tegmental area and dopamine release in the nucleus accumbens core flexibly showed bidirectional excitatory and inhibitory responses to water and salt intake in a state-dependent manner. Furthermore, these dopaminergic and behavioral responses were recapitulated by a homeostatic reinforcement learning model that formalizes reward as reductions in homeostatic drive and punishment as its escalation. Our results demonstrate the nutritional state-dependency of value coding in mesolimbic dopamine systems, providing new insights into neural circuits underlying homeostatic regulation of appetitive and avoidance behaviors.
出版者	Nature Research
収録物名	npj Science of Food
巻(号)	9
ページ	197
刊行年月	2025-09-30
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103488
eISSN	23968370
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41538-025-00558-w
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	npj Science of Food. 2025, 9, p. 197
DC.title	Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance
DC.creator	Ozawa, Takaaki
	Nakagawa, Issei
	Uchida, Yuuki
	Abe, Mayuka
	Macpherson, Tom
	Yamashita, Yuichi
	Hikida, Takatoshi
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-09-30
DC.identifier	https://doi.org/10.1038/s41538-025-00558-w
DC.description	Ozawa T., Nakagawa I., Uchida Y., et al. Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance. npj Science of Food 9, 197 (2025); https://doi.org/10.1038/s41538-025-00558-w.
DCTERMS.abstract	Homeostatic imbalances elicit strong cravings, such as thirst and salt appetite, to restore equilibrium. Although midbrain dopaminergic neurons are known to encode the value of foods, their nutritional state-dependency remains unknown. Here, we show that the activity of the dopaminergic mesolimbic pathway flexibly expresses the positive and negative values of water and salt depending on the internal state in mice. Mice showed behavioral preference and aversion to water and salt depending on their internal water and sodium balance. Fiber photometry recordings revealed that dopamine neurons in the ventral tegmental area and dopamine release in the nucleus accumbens core flexibly showed bidirectional excitatory and inhibitory responses to water and salt intake in a state-dependent manner. Furthermore, these dopaminergic and behavioral responses were recapitulated by a homeostatic reinforcement learning model that formalizes reward as reductions in homeostatic drive and punishment as its escalation. Our results demonstrate the nutritional state-dependency of value coding in mesolimbic dopamine systems, providing new insights into neural circuits underlying homeostatic regulation of appetitive and avoidance behaviors.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	103488
citation_title	Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance
citation_author	Ozawa, Takaaki
	Nakagawa, Issei
	Uchida, Yuuki
	Abe, Mayuka
	Macpherson, Tom
	Yamashita, Yuichi
	Hikida, Takatoshi
citation_publisher	Nature Research
citation_language	英語
citation_date	2025-09-30
citation_journal_title	npj Science of Food
citation_volume	9
citation_firstpage	197
citation_doi	https://doi.org/10.1038/s41538-025-00558-w
citation_public_url	https://hdl.handle.net/11094/103488

Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance

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