Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice

Ito, Akane; Usui, Noriyoshi; Doi, Miyuki et al.

Translational Psychiatry, 2025, 15, 364

アクセス数:43件（2026-02-16 12:11 集計）

固定URL: https://hdl.handle.net/11094/103493

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タイトル
Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice
著者
著者名
Ito, Akane
NRID
1000000784076 1000000784076
ORCID
0000-0001-8079-8013 0000-0001-8079-8013
researchmap permalink
noriyoshiusui noriyoshiusui
Scopus Author ID
56404181300 56404181300
著者名
Usui, Noriyoshi
NRID
1000080954007 1000080954007
researchmap permalink
doim26 doim26
著者名
Doi, Miyuki
NRID
1000020216063 1000020216063
ORCID
0000-0001-5369-1069 0000-0001-5369-1069
researchmap permalink
556shimada 556shimada
Scopus Author ID
35452177800 35452177800
著者名
Shimada, Shoichi
内容
Ito A., Usui N., Doi M., et al. Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice. Translational Psychiatry 15, 364 (2025); https://doi.org/10.1038/s41398-025-03613-y.
抄録
The adolescent brain, characterized by its high plasticity, is particularly vulnerable to substance abuse, leading to long-term impacts on brain function and behavior. Methamphetamine (METH), a potent psychostimulant, is associated with severe neurological and psychiatric consequences. While most studies focus on METH exposure in adulthood, little is known about the effects of adolescent METH exposure. In this study, we explored the long-term effects of adolescent METH exposure on brain function and behavior in adulthood using a mouse model. Mice were administered METH for 8 days during adolescence, and their behavior was analyzed in adulthood. METH-exposed mice (METH mice) displayed anxiety-like behaviors, cognitive decline, and increased microglial numbers in the medial prefrontal cortex (mPFC) and dorsal hippocampus (dHIP). Additionally, METH exposure during adolescence induced neuroinflammation in adulthood. Adolescent METH exposure also enhances defensive reactivity to neuroinflammation and oxidative stress by activating the NFE2L2-mediated redox system and promotes neurogenesis in adulthood. These findings suggest that the detrimental effects of adolescent METH exposure extend into adulthood, emphasizing the delayed-onset impact of early exposure to psychostimulants.
出版者
Springer Nature
収録物名
Translational Psychiatry
巻(号)
15
ページ
364
刊行年月
2025-10-06
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103493
eISSN
21583188
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1038/s41398-025-03613-y
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article